CA-125, CA-153, and CYFRA21-1 as clinical indicators in male lung cancer with ocular metastasis

Abstract

Despite recent improvements in diagnosis and therapy, lung cancer remains the most common malignant tumor in males, with high morbidity and mortality. As the annual incidence continues to increase worldwide, the prognosis for male patients with lung cancer remains unsatisfactory. Interestingly, smoking is associated with lung cancer and ocular lesions by altering risk factors such as carbohydrate antigen (CA)-125, CA-153 and cytokeratin-19 fragment (CYFRA21-1). A diagnostic standard for serum biomarker levels of ocular metastasis (OM) in males with lung cancer is therefore urgently needed. In this retrospective analysis, we examined the relationship between smoking preference and OM in male patients with lung cancer to identify an independent prognostic factor or establish a quantitative indicated standard for OM using the clinical indexes from 2238 cases of male lung cancer. The combination of CA-125, CA-153 and CYFRA21-1 could help diagnose OM in male lung cancer patients. This finding might lead to more timely diagnosis and effective therapies.

Camrelizumab and Apatinib Combined with Radiotherapy Is Effective in Advanced Oligometastatic Non-Small-Cell Lung Cancer

“…SCC-Ag is a glycoprotein secreted in dividing tumors, and its expression may be increased during rapid proliferation or marked differentiation. CYFRA21-1 is an active substance with enhanced tumor cell morphology, and its role is to enhance tumor cell infiltration into the basement membrane and epithelial-mesenchymal transition [ 15 ]. TRIM27 can activate the NF- κ B signaling pathway and activate the transcription of the downstream target genes DKK1 and c-Myc of the Wnt/ β -catenin pathway, thereby promoting their proliferation and activation.…”

<p>Development and Validation of a Novel Nomogram for Predicting Tumor-Distant-Metastasis in Patients with Early T1-2 Stage Lung Adenocarcinoma</p>

“…Another study also showed that CA-125, CA-153, and Cyfra21-1 is an important clinical biomarker in male lung cancer with ocular metastasis. 26 In this study, the univariate and multivariate logistic analysis showed that high levels of CEA, NSE, and Cyfra21-1 were independent risk factors for ET-LUAD and may more easily become distant metastasis. Besides, the established nomogram had a high consistency (C-index=0.792) and good calibration, suggesting that nonmetastatic patients with high serum tumor biomarkers may be provided an important clinical application value to predict the ET-LUAD micrometastasis.…”

Tumorigenic Potential of Dimethyl Sulfoxide, Anthracene in Fish and Anthracene in Dimethyl Sulfoxide in Rattus Norvegicus

“…The increased cancer antigen 125 (CA-125) and carcinoembryonic antigen (CEA) observed in all the treated groups confirm tumorigenic potential of DMSO and anthracene in the present study. CA-125 and CEA have been reported to be biomarkers of non-small cell lung cancer, lung tumour, lung adenocarcinoma, liver and ocular metastases secondary to lung cancer (Salficet al, 2000;Diezet al, 1991;Bucheri and Ferrigno, 2002;Yang et al, 2018;Li et al, 2020;Zanget al, 2019;Isakssonet al, 2017;Wang et al, 2020) as indicated by gross pathology and histopathology of the lung lesions. The two antibodies could be used also for lung cancer screening, liver and ocular metastases secondary to lung cancer and as a predictor of resectable lung adenocarcinoma recurrence (Yang et al, 2018;Wang et al, 2020;Li et al, 2020;Isakssonet al, 2017).Therefore, oncologist should take cognisance of clinical relevance of anaemia in lung cancer (Pirkeret al, 2003), because observed anaemia could be exacerbated by some anticancer drugs (Crawford et al, 2006).…”