CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

Abstract

Purpose: The aim of this study was to analyze associations between serum cancer antigen 125 (CA 125) levels and left ventricular (LV) function in patients with end-stage renal disease on maintenance hemodialysis (HD). Methods: CA 125 levels, pro-brain natriuretic peptide (pro-BNP) and biochemical parameters were measured, and echocardiography was performed for 110 patients and 47 healthy controls. Results: The mean CA 125 level in patients, 38.78 AE 35.48 U/ mL, was significantly higher than that found in healthy controls (9.20 AE 4.55 U/mL; p ¼ 0.003). Patients with elevated CA 125 levels (n ¼ 40) had significantly lower levels of albumin and reduced relative wall thickness, LV ejection fraction (EF) and fractional shortening but significantly higher levels of pro-BNP and a greater left ventricular end-diastolic diameter (LVEDd) and -systolic diameter (LVESd). CA 125 levels were positively correlated with pro-BNP (r ¼ 0.596, p50.05) and C-reactive protein (CRP) levels (r ¼ 0.439, p50.05), as well as LVEDd (r ¼ 0.599, p50.001), LVESd (r ¼ 0.750, p50.001) and LV mass index (r ¼ 0.378, p50.05). In contrast, serum CA 125 levels were negatively correlated with albumin (r ¼ À0.513, p50.05) and hemoglobin (r ¼ À0.475, p50.05) as well as the EF (r ¼ À0.878, p50.0001). A depressed EF ( ¼ À1.121, p50.0001) and increased CRP levels ( ¼ 0.247, p ¼ 0.035) were independent predictors of high CA 125 levels in the whole group in the multivariate-model. Conclusions: Our study is the first to demonstrate an association between serum CA 125 levels and LV systolic dysfunction via inflammation in patients on maintenance HD.

Human epididymis protein 4 (HE4) in laboratory medicine and an algorithm in renal disorders

“…CEA, SCC, NSE, S-100, and PSA) in the presence of decreased kidney function, since these parameters showed a high false-positive rate, and thus were unreliable for monitoring malignancies in uremic patients [65][66][67]. In a very recent paper, CA125 levels were modified by impaired left ventricular function in patients with end-stage renal diseases [68]. In our own study [69], elevated HE4 levels could already be measured at early stages of chronic kidney disease (CKD), while CA125 values were significantly higher compared to healthy individuals only in CKD4-5, suggesting that CA125 was less affected by estimated glomerular filtration rate (eGFR) than HE4.…”

Association between CA-125, ESR, and high-sensitive C-reactive protein and cardiac function in hemodialysis patients

“…The results of this study showed that CA-125 may be a useful biomarker to be addressed in CKD patients on hemodialysis with systolic HF. In a previous study (10) including 110 maintenance hemodialysis patients and 47 healthy controls, mean CA-125 levels in hemodialysis group (38.7 U/mL) was significantly higher in comparison to healthy subjects (9.2 U/mL; P = 0.003). This contradicts our findings as we did not find significant difference regarding CA-125 between hemodialysis and healthy subjects.…”

“…This contradicts our findings as we did not find significant difference regarding CA-125 between hemodialysis and healthy subjects. The authors (10), then divided the hemodialysis group (based on CA-125 level of 26.6 U/mL) into two groups. Those with CA-125 levels of more than 26.6 U/mL had significantly higher LVESD and LVEDD and lower LVEF (32% vs. 59%).…”

Cardiomyopathy in chronic kidney disease: clinical features, biomarkers and the contribution of murine models in understanding pathophysiology

“…Another marker, cancer antigen 125 (CA125), emerged in the literature as positively and consistently associated with a higher risk of 1-year all-cause and cardiovascular mortality throughout the whole spectrum of eGFR categories, independent of kidney function [ 60 ]. Serum CA125 levels are also associated with LV dysfunction in hemodialysis patients [ 68 ].…”