CA 125, PET alone, PET–CT, CT and MRI in diagnosing recurrent ovarian carcinoma

Gu, Ping; Pan, Lingling; Wu, Shaofang; Sun, Li; Huang, Gang

doi:10.1016/j.ejrad.2008.02.019

Cited by 254 publications

(167 citation statements)

References 59 publications

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“…Due to the extensive surgical procedure, a variety of postsurgical tissue alterations are found including nodules and adhesions due to scar tissue as well as thickening and variably increased glucose uptake of the bowel wall due to inflammatory reaction [28]. The aim is to differenti- ate between these postsurgical alterations and remaining or recurring tumor manifestations after HIPEC [29]. Due to the promising results in the preoperative assessment of PC, F-18-FDG PET/CT seems to be an optimal technique to evaluate patients after HIPEC as it is at least comparable if not better than other imaging modalities in the preoperative setting [12].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Relapse in Patients with Peritoneal Carcinomatosis after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy using F-18-FDG-PET/CT

Klumpp

Schwenzer

Gatidis

et al. 2014

Fortschr Röntgenstr

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Purpose: In patients with peritoneal carcinomatosis (PC), cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is an evolving therapeutic approach with curative intention. The differentiation between posttherapeutic findings after HIPEC and relapse of PC is challenging. We evaluated the diagnostic value of F-18-FDG-PET/CT in patients with relapse of PC after HIPEC. Materials and Methods: 36 patients with recurring PC after HIPEC were examined on a whole-body PET/CT system (44 examinations). The examination included 3?D F-18-FDG-PET and contrast-enhanced CT. Images were assessed by two experienced readers regarding the presence and the extent of PC using the peritoneal carcinomatosis index (PCI). Imaging results were correlated with surgical findings or follow-up. Results: Relapse was suspected in 40 of 44 examinations. Relapse was missed by F-18-FDG PET/CT in 4 patients and significantly underestimated in 8 patients. The diagnostic accuracy for the detection of PC on a patient basis was 91?%, the sensitivity was 91?% and the positive predictive value was 100?%. The mean PCI was 11.4???11.9 for PET/CT, 8.4???10.3 for CT and 16.6???15.0 in the case of surgical exploration. The extent of PC was underestimated by PET/CT and even more by CT alone (p?

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Section: Discussionmentioning

confidence: 99%

Assessment of Relapse in Patients with Peritoneal Carcinomatosis after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy using F-18-FDG-PET/CT

Klumpp

Schwenzer

Gatidis

et al. 2014

Fortschr Röntgenstr

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“…For ovarian cancer, both sensitivity and specificity in detecting PM is in the range of 78 %-97 %. [28][29][30][31][32][33] A recent metaanalysis of imaging modalities for recurrent ovarian cancer showed that PET-CT had the highest pooled sensitivity of 92 %,compared with PET,CT or MRI alone [34].…”

Section: Positron Emission Tomography (Pet) Scan and Pet-ctmentioning

confidence: 99%

Role of Imaging in Peritoneal Surface Malignancies

Krishnamurthy

Balasubramaniam

2016

Indian J Surg Oncol

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“…Increased FDG uptake in post menopausal women is abnormal. With regards to tumour recurrence detection, PET/ PET-CT is superior to CT and MRI with higher sensitivity and specificity [9,10].…”

Section: Positron Emission Tomography (Pet)/ Pet-ctmentioning

confidence: 99%

An Algorithm Based Approach To Ovarian Neoplasms

Mathew¹

2016

IJARS

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Introduction: Cancer of the ovaries is the 2 nd most common gynaecological malignancy and has the highest mortality rate among all gynaecological malignancies with an overall 5 year survival rate of 46%. A large number of the lesions are incidentally detected, for which imaging plays a vital role in treatment planning by characterizing these masses. Identifying benign lesions accurately may obviate unnecessary surgery, where as indeterminate or malignant lesions will require surgery with or without radio/chemotherapy. Aim:To inform the readers the imaging patterns of common and rarely encountered ovarian neoplasms and to provide an algorithm based approach to these ovarian lesions, which will not only aid in the management of these conditions but also obviate unnecessary investigations and surgeries. Materials and Methods:This was a prospective study conducted over a period of one year from January 2014 to January 2015 at the Department of Radiology, Father Muller Medical College, Mangalore, India. Data were collected from 82 patients who presented with ovarian cystic lesions on ultrasound and were either followed up by USG or underwent further evaluation by CT. Diagnosis was confirmed by histopathology. Statistical analysis involved percentage frequency.

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CA 125, PET alone, PET–CT, CT and MRI in diagnosing recurrent ovarian carcinoma

Cited by 254 publications

References 59 publications

Assessment of Relapse in Patients with Peritoneal Carcinomatosis after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy using F-18-FDG-PET/CT

Assessment of Relapse in Patients with Peritoneal Carcinomatosis after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy using F-18-FDG-PET/CT

Role of Imaging in Peritoneal Surface Malignancies

An Algorithm Based Approach To Ovarian Neoplasms

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