Ca 2+-45 Cyclotron Resonance in Human Lymphocytes

Liboff, Abraham R.; Rozek, Richard J.; Sherman, Matthew L.; McLeod, Bruce R.; Smith, Stephen D.

doi:10.3109/15368378709027725

Cited by 47 publications

(50 citation statements)

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“…= 1.8. We interprete this to mean that at this field intensity ratio a change in biological response will be maximal; this could be enhancement or inhibition of a process since there is no direct interpretation for the change in ion probability, P. This analysis leads to the same predicted frequency for a given ion as previously proposed for 'q/m' interactions [3,4], however, it has the additional feature that the a.c./d.c, field intensity ratio is specified. Such specifications enable experimental testing as we report here.…”

Section: Introductionsupporting

confidence: 56%

“…field combinations which follow a 'q/m ° relation act to influence calcium transport of human peripheral blood lymphocytes [3,4]. These lymphocytes were not treated with mitogen, as done here.…”

Section: Discussionmentioning

confidence: 99%

“…A question that is central to interaction mechanisms of magnetic fields and biological systems is whether a time-varying (a.c.) magnetic field interacts in a fundamentally different manner at the cellular level when a static (d.c.) magnetic field is present [1][2][3][4][5][6][7]. This question is of interest since both ELF magnetic fields and geomagnetic static magnetic fields are present in the environment and workplace, and since it is critically important to identify field metrics that have biological relevance.…”

Section: Introductionmentioning

confidence: 99%

“…In the home and environment these exposures involve magnet-Volume 296, number 2 FEBS ic field flux densities in the 2-400 mGauss range. The experimental evidence supporting the possibility that such low-intensity combined a.c./d.c, fields interact with biological systems comes from studies in which the a.c./ d.c. fields are oriented perpendicular [2] or parallel [3] to each other. Perpendicular orientation can be thought of as a nuclear magnetic resonance-type interaction, while the parallel orientation can be thought of as a "q/m' cyclotron interaction.…”

Section: Introductionmentioning

confidence: 99%

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Time‐varying and static magnetic fields act in combination to alter calcium signal transduction in the lymphocyte

1992

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We have tested the hypothesis that extremely low frequency (ELF) time.varying magnetic fields act in combination with static magnetic fields to alter calcium ~ignalling in the lymphocyte. Results indicate that a 60-rain exposure of thymic lymphocytes at 37 ± 0.05°C to a 16 Hz, 421 mG (42.1 /aT) magnetic field simultaneously with a colinear static magnetic field of 234 mG (23.4/aT) (a.c./d.c. field intensity ratio = 1.8) inhibits calcium influx triggered by the mitogen Concanavalin A. Significantly, resting lymphocytes do not respond to the fields, thus, only mitogen-activated cells underBoin~ calcium signalling exhibit a field response. These results indicate that signal transduction involving calcium is an important biological cottslrclbtt which operates to mediate this field interaction. Additional split field exposures show that the presence of the a.c. field or the d.c. field alone does not produce an effect. This is consistent with a proposed parametric resonance theory of interaction of low intensity magnetic fields with biological systems (L.L. Ledncv (1991) Bioelextromagnetics 12, 71-75), whlch predicts the oceurran~ of biological effects at Sl~cific values for the frequency and field intensity of the ELF and static magnetic fields.

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Section: Introductionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Time‐varying and static magnetic fields act in combination to alter calcium signal transduction in the lymphocyte

1992

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“…Considering EM interactions from a purely physical point of view, several mechanisms have been proposed to account for the initial interactions with cells (Liboff et al, 1987;Lednev, 1991;Blanchard and Blackman, 1994), but these models have been limited by their inability to account for the wide range of experimental observations. The Mobile Charge Interaction (MCI) model (Blank, 1995a), based on simple physical interactions, grew out of a wide range of experiments.…”

mentioning

confidence: 99%

Insights into electromagnetic interaction mechanisms

Goodman

Blank

2002

Journal Cellular Physiology

166

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Low frequency (< 300 Hz) electromagnetic (EM) fields induce biological changes that include effects ranging from increased enzyme reaction rates to increased transcript levels for specific genes. The induction of stress gene HSP70 expression by exposure to EM fields provides insight into how EM fields interact with cells and tissues. Insights into the mechanism(s) are also provided by examination of the interaction of EM fields with moving charges and their influence on enzyme reaction rates in cell-free systems. Biological studies with in vitro model systems have focused, in general, on the nature of the signal transduction pathways involved in response to EM fields. It is likely, however, that EM fields also interact directly with electrons in DNA to stimulate biosynthesis. Identification of an EM field-sensitive DNA sequence in the heat shock 70 (HSP70) promoter, points to the application of EM fields in two biomedical applications: cytoprotection and gene therapy. EM field induction of the stress protein hsp70 may also provide a useful biomarker for establishing a science-based safety standard for the design of cell phones and their transmission towers.

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