Ca(2+) Ion and Autophagy

Hu, Yang-Xi; Han, Xiao-Shuai; Jing, Qing

doi:10.1007/978-981-15-0602-4_7

Cited by 36 publications

(28 citation statements)

References 17 publications

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“…Activation of the 5-HT 3 receptor results in the influx of extracellular calcium ions that mobilizes and increases the concentration of intracellular calcium ( 49 ). The regulation of mTOR-dependent autophagy by intracellular calcium remains controversial ( 50 ). Therefore, further studies are deserved to elucidate the role of 5-HT receptors expressed on IECs in the regulation of autophagy in CD.…”

Section: Discussionmentioning

confidence: 99%

Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn’s disease

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn’s disease

et al. 2021

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“…The interplay between lysosomal Ca 2+ signal and autophagy has also been reported. In line with this, several lysosomal Ca 2+ -permeable channels have been suggested to regulate autophagy [119][120][121].…”

Section: Lysosomal Ca 2+ In Autophagy 41 Trpml Channels In Autophagymentioning

confidence: 68%

Lysosomal Calcium Channels in Autophagy and Cancer

Huang

Dong

2021

Cancers

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Ca2+ is pivotal intracellular messenger that coordinates multiple cell functions such as fertilization, growth, differentiation, and viability. Intracellular Ca2+ signaling is regulated by both extracellular Ca2+ entry and Ca2+ release from intracellular stores. Apart from working as the cellular recycling center, the lysosome has been increasingly recognized as a significant intracellular Ca2+ store that provides Ca2+ to regulate many cellular processes. The lysosome also talks to other organelles by releasing and taking up Ca2+. In lysosomal Ca2+-dependent processes, autophagy is particularly important, because it has been implicated in many human diseases including cancer. This review will discuss the major components of lysosomal Ca2+ stores and their roles in autophagy and human cancer progression.

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“…Three kinds of autophagy are found in mammals: macroautophagy, microautophagy and chaperone-mediated autophagy ( Dikic and Elazar, 2018 ). Recent studies have reported that autophagy is regulated by autophagy-related genes (ATG) ( Li and Zhang, 2019 ), mammalian target of rapamycin (mTOR) ( Munson and Ganley, 2015 ), adenosine 5′-monophosphate-activated protein kinase (AMPK) ( Li and Chen, 2019 ), Ca 2+ ( Hu et al, 2019 ) and NOD2 ( Negroni et al, 2016 ).…”

Section: Autophagy In Ucmentioning

confidence: 99%

Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis

Qiao

Zhang

et al. 2021

Front. Pharmacol.

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Ulcerative colitis (UC) is a chronic nonspecific inflammation that mainly affects the mucosa and submucosa of the rectum and colon. Numerous studies have shown that endoplasmic reticulum stress (ERS)-induced autophagy plays a vital role in the pathogenesis of UC. ERS is the imbalance of internal balance caused by misfolded or unfolded proteins accumulated in the endoplasmic reticulum (ER).Excessive ERS triggers the unfolded protein response (UPR), an increase in inositol-requiring enzyme 1, and a Ca2+ overload, which activates the autophagy pathway. Autophagy is an evolutionarily conserved method of cellular self-degradation. Dysregulated autophagy causes inflammation, disruption of the intestinal barrier, and imbalance of intestinal homeostasis, therefore increasing the risk of colonic diseases. This review summarizes the pathogenesis of ERS, UPR, and ERS-related autophagy in UC, providing potential new targets and more effective treatment options for UC.

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Ca(2+) Ion and Autophagy

Cited by 36 publications

References 17 publications

Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn’s disease

Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn’s disease

Lysosomal Calcium Channels in Autophagy and Cancer

Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis

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