2003
DOI: 10.1002/jbm.a.10538
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Ca/P ratio effects on the degradation of hydroxyapatite in vitro

Abstract: Phase purity is a well-recognized but not well-understood variable affecting the biological integration of hydroxyapatite (HA)-based biomaterials. Minor amounts of specific, relevant impurities--calcium oxide (CaO) and tricalcium phosphate (TCP)--may often be present either as deliberate additions or as a result of decomposition during sintering. We investigated the influence of these two impurities in terms of their effects on surface morphology, weight loss/gain, and microstructural-level degradation. Phase … Show more

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Cited by 131 publications
(94 citation statements)
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“…The results of the investigation using EDS, after each treatment stage (at three points on the sample surface), are presented in Figure 2 and Table 1. The Ca/P ratio on the surface was 1.7, in which the mean ratios Ca/P = 1.67 [14,15] were indicated. The study of the processes involved in the formation of hydroxyapatite crystals on the titanium surface provides evidence that their inception depends on the number of surface hydroxyl groups present [4].…”
Section: Resultsmentioning
confidence: 93%
“…The results of the investigation using EDS, after each treatment stage (at three points on the sample surface), are presented in Figure 2 and Table 1. The Ca/P ratio on the surface was 1.7, in which the mean ratios Ca/P = 1.67 [14,15] were indicated. The study of the processes involved in the formation of hydroxyapatite crystals on the titanium surface provides evidence that their inception depends on the number of surface hydroxyl groups present [4].…”
Section: Resultsmentioning
confidence: 93%
“…Preparation of pure and biphasic HA Stoichiometric HA powder (Ca/P ratio ϭ 1.67) was prepared by a modification 30 of a mechanochemical-hydrothermal method. 31 (NH 4 ) 2 HPO 4 powder (Fisher Scientific, Fairlawn, NJ) was slowly added to a suspension of Ca(OH) 2 (Fisher Scientific) in deionized water.…”
Section: Methodsmentioning
confidence: 99%
“…31 (NH 4 ) 2 HPO 4 powder (Fisher Scientific, Fairlawn, NJ) was slowly added to a suspension of Ca(OH) 2 (Fisher Scientific) in deionized water. We found it necessary protect the solution using a nitrogen blanket 30 to exclude atmospheric carbon dioxide and the unintended formation of CaCO 3 . The resulting slurry was stirred for 10 min and then attritor-milled (Szegvari Attritor) for 10 h at room temperature 31 and dried in a vacuum oven at 80°C (again excluding atmospheric CO 2 ) for 24 h. The median particle size was determined to be ϳ0.7 m (CAPA-4, Horiba).…”
Section: Methodsmentioning
confidence: 99%
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