Ca²⁺ and innate immune pathways are activated and differentially expressed in childhood asthma phenotypes

Abstract

Ca regulation and innate immunity response pattern to viruses were activated in PBMCs of asthmatics. Asthma phenotypes were differentially characterized by distinct regulation of ATP2A3 and expression of innate immune receptors (FPR2, CLEC4E, IFIH1). These genes may present promising targets for future in-depth investigation with the long-term goal of more phenotype-specific therapeutic interventions in asthmatics.

Hub Genes Identification in a Murine Model of Allergic Rhinitis Based on Bioinformatics Analysis

“…FPR2 is a unique G-protein-coupled receptor, which is critical to the resolution of inflammation (Cooray et al, 2013). Previous studies have reported that Anxa1 and FPR2 play an important role in the pathogenesis of asthma (Perucci et al, 2017;Boeck et al, 2018;Lee et al, 2018). Anxa1 can reduce inflammation by regulating neutrophil transmigration, promoting neutrophil apoptosis and efferocytosis, inducing tissue repair, and recruiting monocytes (Maderna et al, 2005;Vago et al, 2012;Sugimoto et al, 2019;Machado et al, 2020).…”

Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function

“…Among the variants investigated, the asthma-increasing risk allele rs2305480*G is associated with the down-regulation of GSDMB , ORMDL3 , and PGAP3 and the up-regulation of GSDMA and IKZF3 across multiple tissues. Accordingly, we can hypothesize that the effect of rs2305480 on asthma risk and the blood levels of immune cells is due to mechanisms related to the function of multiple genes, including the GSDMB and GSDMA regulation of apoptosis in epithelial cells, 33 34 ORMDL3 regulation of the innate immune system, 35 and IKZF3 regulation of B lymphocyte proliferation and differentiation. 36 37 Among the other variants tested, the asthma-increasing risk rs1558641*G allele was associated with the up-regulation of MFSD9 and down-regulation of IL18R1 .…”

The effect of short term microbial exposure and diversity on allergy, and how FcεRI expression on inflammatory cells modulates asthma

“…12 This publication adds additional insights into the mechanisms of asthma. Readers with a special research interest in the field might also refer to these recent original publications in PAI [13][14][15] or to a recent review on oxidative stress and asthma. 16 Eila Kujansuu Jinpao Hou (le[) and Jennifer Wing-Ki Yau (right) Jonatan Leffler (le[) and James F. Read (right)…”

“…This publication adds additional insights into the mechanisms of asthma. Readers with a special research interest in the field might also refer to these recent original publications in PAI or to a recent review on oxidative stress and asthma …”