Ca<sup>2+</sup>Signaling in the Liver

Leite, Fatima M.; Guerra, Mateus T.; Nathanson, Michael H.

doi:10.1002/9780470747919.ch32

Cited by 4 publications

(6 citation statements)

References 285 publications

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“…For example, lower concentrations of ATP predominantly induce sustained Ca 2+ oscillations, whereas higher concentrations predominantly induce single, brief Ca 2+ increases. In contrast, ACh does not display clear dose dependence, and the spikes it induces tend to be irregular in duration (although typically longer as compared to ATP induced) and frequency (161, 200, 210). This variability may enable different stimuli to elicit nuanced and distinct physiological effects even though they all act through modulation of intracholangiocyte Ca 2+ signaling (203).…”

Section: Intracellular Signalingmentioning

confidence: 87%

Physiology of Cholangiocytes

Tabibian

Masyuk

et al. 2013

Comprehensive Physiology

208

207

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Cholangiocytes are epithelial cells that line the intra- and extrahepatic ducts of the biliary tree. The main physiologic function of cholangiocytes is modification of hepatocyte-derived bile, an intricate process regulated by hormones, peptides, nucleotides, neurotransmitters, and other molecules through intracellular signaling pathways and cascades. The mechanisms and regulation of bile modification are reviewed herein.

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Section: Intracellular Signalingmentioning

confidence: 87%

Physiology of Cholangiocytes

Tabibian

Masyuk

et al. 2013

Comprehensive Physiology

208

207

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“…Nuclear PIP2 is depicted. However, its exact localization within the nucleus remains unknown [modified from references (211) and (137), with permission].…”

Section: Figurementioning

confidence: 99%

Calcium Signaling in the Liver

Amaya

Nathanson

2013

Comprehensive Physiology

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Intracellular free Ca2+ ([Ca2+]i) is a highly versatile second messenger that regulates a wide range of functions in every type of cell and tissue. To achieve this versatility, the Ca2+ signaling system operates in a variety of ways to regulate cellular processes that function over a wide dynamic range. This is particularly well exemplified for Ca2+ signals in the liver, which modulate diverse and specialized functions such as bile secretion, glucose metabolism, cell proliferation, and apoptosis. These Ca2+ signals are organized to control distinct cellular processes through tight spatial and temporal coordination of [Ca2+]i signals, both within and between cells. This article will review the machinery responsible for the formation of Ca2+ signals in the liver, the types of subcellular, cellular, and intercellular signals that occur, the physiological role of Ca2+ signaling in the liver, and the role of Ca2+ signaling in liver disease.

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“…27 Hepatocytes and SKHep1 cells were observed during perfusion with vasopressin, which causes an InsP3-mediated increase in Ca i 2+ in both of these cell types. 1,30 Similarly, pancreatic acinar cells were stimulated with ACh, which causes an InsP3-mediated increase in Ca i 2+ in these cells. 20 Apical and basal regions were identified within the cytosol of individual cells, and the Ca i 2+ signals in those regions were determined from the recorded images.…”

Section: Ca 2+ Measurementsmentioning

confidence: 99%

“…8 The InsP3R generally is in the ER membrane, 1 although it has been identified in the plasma membrane as well in some cells. 32,33 To determine whether the InsP3R in hepatocytes is in the canalicular membrane or the nearby ER, we performed triple-label confocal immunofluorescence studies of rat liver.…”

Section: The Type II Insp3r Is Localized To the Pericanalicular Er Inmentioning

confidence: 99%

“…[1][2][3] Ca 2+ is able to regulate such a range of cell functions because of the diverse temporal and spatial patterns of Ca 2+ signals that can be encoded. For example, temporal patterns of Ca 2+ signals such as Ca 2+ oscillations encode information in the oscillation frequency, and frequency modulation can differentially regulate expression of transcription factors and cytokines.…”

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confidence: 99%

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