Ca2+/Calmodulin Complex Triggers CAMTA Transcriptional Machinery Under Stress in Plants: Signaling Cascade and Molecular Regulation

Iqbal, Zahra; Iqbal, Mohammad Perwaiz; Singh, Surendra; Buaboocha, Teerapong

doi:10.3389/fpls.2020.598327

Cited by 69 publications

(47 citation statements)

References 175 publications

(295 reference statements)

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“…B, C, and D). As already discussed, CAMTAs are Ca 2+ /CaM-regulated TFs that have long been linked to phytohormones, such as ABA, ethylene, and auxins [ 14 ]. Coherently, DzCAMTA3PinG and DzCAMTA8PinG were linked with positive regulation of ABA, ethylene, and auxins (Additional file 6 - Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Ca 2+ is an important second messenger that mediates responses to external stimuli and hormonal fluctuations via Ca 2+ sensors, such as CaM [ 14 , 77 , 78 ]. The role of Ca 2+ is further extended in fruit ripening via the intervention of cross-wired mesh of regulatory networks [ 27 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

“…Often, molecular mechanisms mediating plant responses to environmental and hormonal signals involve signaling cascades in which Ca 2+ acts as a pivotal second messenger [ 12 , 13 ]. Perturbations in cytosolic Ca 2+ levels are sensed and interpreted by an array of Ca 2+ -binding proteins that function as signal sensors [ 14 , 15 ]. Calmodulin (CaM) is a well-characterized Ca 2+ sensor, which is known to modulate target proteins such as TFs [ 16 ], including the well-known CaM-binding transcription activators (CAMTAs) [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive genome-wide analysis of calmodulin-binding transcription activator (CAMTA) in Durio zibethinus and identification of fruit ripening-associated DzCAMTAs

Iqbal

Sangpong

et al. 2021

BMC Genomics

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Background Fruit ripening is an intricate developmental process driven by a highly coordinated action of complex hormonal networks. Ethylene is considered as the main phytohormone that regulates the ripening of climacteric fruits. Concomitantly, several ethylene-responsive transcription factors (TFs) are pivotal components of the regulatory network underlying fruit ripening. Calmodulin-binding transcription activator (CAMTA) is one such ethylene-induced TF implicated in various stress and plant developmental processes. Results Our comprehensive analysis of the CAMTA gene family in Durio zibethinus (durian, Dz) identified 10 CAMTAs with conserved domains. Phylogenetic analysis of DzCAMTAs, positioned DzCAMTA3 with its tomato ortholog that has already been validated for its role in the fruit ripening process through ethylene-mediated signaling. Furthermore, the transcriptome-wide analysis revealed DzCAMTA3 and DzCAMTA8 as the highest expressing durian CAMTA genes. These two DzCAMTAs possessed a distinct ripening-associated expression pattern during post-harvest ripening in Monthong, a durian cultivar native to Thailand. The expression profiling of DzCAMTA3 and DzCAMTA8 under natural ripening conditions and ethylene-induced/delayed ripening conditions substantiated their roles as ethylene-induced transcriptional activators of ripening. Similarly, auxin-suppressed expression of DzCAMTA3 and DzCAMTA8 confirmed their responsiveness to exogenous auxin treatment in a time-dependent manner. Accordingly, we propose that DzCAMTA3 and DzCAMTA8 synergistically crosstalk with ethylene during durian fruit ripening. In contrast, DzCAMTA3 and DzCAMTA8 antagonistically with auxin could affect the post-harvest ripening process in durian. Furthermore, DzCAMTA3 and DzCAMTA8 interacting genes contain significant CAMTA recognition motifs and regulated several pivotal fruit-ripening-associated pathways. Conclusion Taken together, the present study contributes to an in-depth understanding of the structure and probable function of CAMTA genes in the post-harvest ripening of durian.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comprehensive genome-wide analysis of calmodulin-binding transcription activator (CAMTA) in Durio zibethinus and identification of fruit ripening-associated DzCAMTAs

Iqbal

Sangpong

et al. 2021

BMC Genomics

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“…Many Ca 2+ and Ca 2+ sensor-associated transcription factors (TFs) are implicated in stress signaling in plants ( Carrion et al, 1999 ; Singh and Virdi, 2013 ; Ranty et al, 2016 ; Chung et al, 2020 ; Shen et al, 2020 ). The largest and best characterized family of Ca 2+ /CaM-dependent TFs are CAMTAs ( Iqbal et al, 2020b ). CAMTA3 has been reported enormously as a suppressor of plant biotic defense responses ( Benn et al, 2016 ; Jacob et al, 2018 ; Kim et al, 2020 ).…”

Section: Biotic Stress and Plant Defense Responsesmentioning

confidence: 99%

Plant Defense Responses to Biotic Stress and Its Interplay With Fluctuating Dark/Light Conditions

et al. 2021

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Plants are subjected to a plethora of environmental cues that cause extreme losses to crop productivity. Due to fluctuating environmental conditions, plants encounter difficulties in attaining full genetic potential for growth and reproduction. One such environmental condition is the recurrent attack on plants by herbivores and microbial pathogens. To surmount such attacks, plants have developed a complex array of defense mechanisms. The defense mechanism can be either preformed, where toxic secondary metabolites are stored; or can be inducible, where defense is activated upon detection of an attack. Plants sense biotic stress conditions, activate the regulatory or transcriptional machinery, and eventually generate an appropriate response. Plant defense against pathogen attack is well understood, but the interplay and impact of different signals to generate defense responses against biotic stress still remain elusive. The impact of light and dark signals on biotic stress response is one such area to comprehend. Light and dark alterations not only regulate defense mechanisms impacting plant development and biochemistry but also bestow resistance against invading pathogens. The interaction between plant defense and dark/light environment activates a signaling cascade. This signaling cascade acts as a connecting link between perception of biotic stress, dark/light environment, and generation of an appropriate physiological or biochemical response. The present review highlights molecular responses arising from dark/light fluctuations vis-à-vis elicitation of defense mechanisms in plants.

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“…The promoter region analysis of the Ca 2+ shows biased nature toward abiotic stress responsive genes. Three among four Ca 2+ regulated promoter regions were reported to be indispensable for abiotic stress responses (Iqbal et al, 2020). About 30 CDPK genes have been reported in Arabidopsis that have role in abiotic stress responses (Hrabak et al, 2003).…”

Section: Omics Approaches To Study the Roles Of Ja Ca 2+ And Gsh Under Abiotic Stressmentioning

confidence: 99%

Role of Jasmonates, Calcium, and Glutathione in Plants to Combat Abiotic Stresses Through Precise Signaling Cascade

et al. 2021

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Plant growth regulators have an important role in various developmental processes during the life cycle of plants. They are involved in abiotic stress responses and tolerance. They have very well-developed capabilities to sense the changes in their external milieu and initiate an appropriate signaling cascade that leads to the activation of plant defense mechanisms. The plant defense system activation causes build-up of plant defense hormones like jasmonic acid (JA) and antioxidant systems like glutathione (GSH). Moreover, calcium (Ca2+) transients are also seen during abiotic stress conditions depicting the role of Ca2+ in alleviating abiotic stress as well. Therefore, these growth regulators tend to control plant growth under varying abiotic stresses by regulating its oxidative defense and detoxification system. This review highlights the role of Jasmonates, Calcium, and glutathione in abiotic stress tolerance and activation of possible novel interlinked signaling cascade between them. Further, phyto-hormone crosstalk with jasmonates, calcium and glutathione under abiotic stress conditions followed by brief insights on omics approaches is also elucidated.

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Ca2+/Calmodulin Complex Triggers CAMTA Transcriptional Machinery Under Stress in Plants: Signaling Cascade and Molecular Regulation

Cited by 69 publications

References 175 publications

Comprehensive genome-wide analysis of calmodulin-binding transcription activator (CAMTA) in Durio zibethinus and identification of fruit ripening-associated DzCAMTAs

Comprehensive genome-wide analysis of calmodulin-binding transcription activator (CAMTA) in Durio zibethinus and identification of fruit ripening-associated DzCAMTAs

Plant Defense Responses to Biotic Stress and Its Interplay With Fluctuating Dark/Light Conditions

Role of Jasmonates, Calcium, and Glutathione in Plants to Combat Abiotic Stresses Through Precise Signaling Cascade

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