“…In many of these cells, CaV3 channels appear to be interspersed in the AIS with other CaV classes. This diversity is most apparent in neocortical pyramidal cells, where calcium influx has been reported to be mediated by a range of channel types, including CaV1, members of the CaV2 family, and CaV3 (Clarkson et al, 2017;Hanemaaijer et al, 2020;Yu et al, 2010) Across neuronal compartments, the spatial organization of CaVs shapes function by linking spatially-restricted calcium influx to nearby calcium-sensitive processes. In somatodendritic compartments, coupling of CaVs to calcium-activated potassium channels regulates action potential (AP) dynamics (Bock and Stuart, 2016;Irie and Trussell, 2017), EPSP amplitude and summation (Chen-Engerer et al, 2019;Wang et al, 2014), and calcium influx (Jones and Stuart, 2013).…”