2005
DOI: 10.1016/j.tins.2005.07.001
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Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS

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Cited by 161 publications
(126 citation statements)
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“…1,42 The low calcium buffering capacity of motoneurons also make it likely that motoneurons cope poorly with injury and die. 43 Motoneuron death was greatest one spinal level below the lesion epicenter In uninjured cases, there was no difference in the estimates for motoneuron numbers when analyzed from large diameter myelinated axons in ventral roots versus counting motoneurons in the FIG. 3.…”
Section: Figmentioning
confidence: 97%
“…1,42 The low calcium buffering capacity of motoneurons also make it likely that motoneurons cope poorly with injury and die. 43 Motoneuron death was greatest one spinal level below the lesion epicenter In uninjured cases, there was no difference in the estimates for motoneuron numbers when analyzed from large diameter myelinated axons in ventral roots versus counting motoneurons in the FIG. 3.…”
Section: Figmentioning
confidence: 97%
“…The resulting increase in Ca 2ϩ influx and oxidative stress because of mitochondrial metabolic demands (Facchinetti et al, 1998) could then further activate PKC in a vicious feedback cycle. Excessive activity-dependent Ca 2ϩ entry may also contribute to cell death in motoneurons, because of their limited cytosolic calcium buffering capacity, so that excess Ca 2ϩ is stored in mitochondria (von Lewinski and Keller, 2005), eventually leading to structural and functional damage. Mitochondrial structure is already abnormal in motoneurons in 2-to 3-week-old hSOD G93A mice (Bendotti et al, 2001), and subsequent mitochondrial breakdown and activation of caspases (Li et al, 2000) may trigger motoneuron death.…”
Section: Msod1mentioning
confidence: 99%
“…For example, conditions that do not elicit free radical production from mitochondria isolated from liver cause brain mitochondria to produce copious amounts of oxygen-and carbon-centered radicals (Dykens, 2007). In addition, mitochondrial impairment that reduce organelle transport within neurons puts them at increased risk of injury (Chang and Reynolds, 2006;von Lewinski and Keller, 2005).…”
Section: Mitochondria and Cell Deathmentioning
confidence: 99%