Ca2+ signaling in taste bud cells and spontaneous preference for fat: Unresolved roles of CD36 and GPR120

Abdoul-Azize, Souleymane; Selvakumar, S.; Sadou, Hassimi; Besnard, Philippe; Khan, Naim Akhtar

doi:10.1016/j.biochi.2013.06.005

Cited by 51 publications

(37 citation statements)

References 66 publications

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“…These may even constitute a sixth taste sensation, the taste of fats, which have previously been thought to be mainly detected through texture. Fat preference may also involve the glycoprotein CD36 (also known as fatty acid translocase or FAT) [54–62]. However, the function of these proteins in human fat taste and fat preference is not yet fully understood and remains an active area of research.…”

Section: The Biology Of Taste and Taste Receptorsmentioning

confidence: 99%

Taste receptors in innate immunity

Lee

Cohen

2014

Cell. Mol. Life Sci.

122

110

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Taste receptors were first identified on the tongue, where they initiate a signaling pathway that communicates information to the brain about the nutrient content or potential toxicity of ingested foods. However, recent research has shown that taste receptors are also expressed in a myriad of other tissues, from the airway and gastrointestinal epithelia to the pancreas and brain. The functions of many of these extraoral taste receptors remain unknown, but emerging evidence suggests that bitter and sweet taste receptors in the airway are important sentinels of innate immunity. This review discusses taste receptor signaling, focusing on the G-protein coupled–receptors that detect bitter, sweet, and savory tastes, followed by an overview of extraoral taste receptors and in-depth discussion of studies demonstrating the roles of taste receptors in airway innate immunity. Future research on extraoral taste receptors has significant potential for identification of novel immune mechanisms and insights into host-pathogen interactions.

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Section: The Biology Of Taste and Taste Receptorsmentioning

confidence: 99%

Taste receptors in innate immunity

Lee

Cohen

2014

Cell. Mol. Life Sci.

122

110

View full text Add to dashboard Cite

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“…The principle and apparatus involved with the licking test were previously described (29). Briefly, prior to the experiments, mice were trained to ingest sufficient amounts of a sucrose solution the circumvallate papillae of rats (9), long-chain fatty acids increase the concentration of intracellular free calcium in taste bud cells where CD36 is likely to be expressed (1), and mice with CD36 gene disruption exhibit a reduced preference to long-chain fatty acids such as linoleate (12). A species of oxidised phospholipid, 1-(palmitoyl)-2-(5-keto-6-octene-dioyl)phosphatidylcholine (KOdiA-PC), is one of the most potent CD36 ligands (20).…”

Section: Two-bottle Choice Testmentioning

confidence: 99%

<b>A role of CD36 in the perception of an oxidised phospholipid species in </b><b>mice </b>

et al. 2015

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CD36 is a broadly expressed transmembrane protein that engages multiple ligands, including polar lipids. This protein is thought to even contribute to the chemosensory detection of long-chain fatty acids in the oral cavity of rodents. In this study, we assessed whether animals consciously perceive a ligand of CD36, 1-(palmitoyl)-2-(5-keto-6-octanedioyl)phosphatidylcholine (KOdiA-PC), and if so, whether CD36 is involved in sensing the oxidised phospholipid species. We found that mice avoided or hesitated to ingest fluids containing KOdiA-PC, suggesting a conscious perception of the lipid in the animals. We assessed the involvement and role of CD36 in the KOdiA-PC perception by comparing the behavioural responses of wild-type and CD36-deficient mice to the test fluids, and provided evidence that the protein could play a role in sensing a lower level of the lipid. We also found that transection of the olfactory nerve of wild-type mice resulted in an inability to perceive KOdiA-PC, suggesting the significance of olfactory system in the lipid sensing. Our findings, coupled with the recent finding of CD36 expression in the mouse olfactory epithelium, led us to predict that the site of CD36 action in the KOdiA-PC sensing plausibly lies within the nasal cavity of the animal.Animals have highly developed chemosensory systems that enable efficient detection of diverse soluble or volatile molecules. Detection of exogenous molecules by taste bud cells and/or olfactory receptor cells transmits signals to the brain and consequently induces various behavioural responses (e.g., appetitive or aversive response to foods) (21, 25). To better understand the mechanisms underlying chemosensory perception, much effort has gone into identifying sensory proteins in the oral and nasal cavities (4, 5). CD36 is a broadly expressed transmembrane protein associated with the recognition of multiple molecules (e.g., amphipathic lipids) (15,19). For instance, in macrophages, CD36 contributes to the clearance of oxidised forms of low-density lipoprotein from the blood by recognising distinct phospholipid species on the surface of the particles (6,20). Furthermore, CD36 expressed by enterocytes is believed to participate in not only recognition and absorption of long-chain fatty acids but also in formation of chylomicrons (18). In addition to its well-characterized functions, CD36 has been postulated to play an important role in the chemosensory detection of longchain fatty acids in the oral cavity, leading to an appetitive response to the lipid species in rodents. Several lines of evidence support this finding: CD36 is localised to the apical surface of taste bud cells in

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“…A recent study has shown that STIM1 in the mouse tongue induces fatty acid Table 5 LSMeans and standard errors for gene expression in population of steers (n = 14) with diverse residual gain phenotypes. Gene calcium signaling and may influence an animal's preference for a high fat diet because Stim1−/− mice lose their preference for long chain fatty acids (Dramane et al, 2012;Abdoul-Azize et al, 2013). There is no such supporting literature regarding this gene in cattle and we did not examine the tongue for STIM1 expression; however, there is some precedence for STIM1 expression in the stomach since expressed sequence tags for STIM1 have been identified in both human and mouse stomach tissue.…”

Section: Discussionmentioning

confidence: 85%