Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer

Qu, Na; Lee, Robert J.; Sun, Yating; Cai, Guangsheng; Wang, Junyang; Wang, Mengqiao; Lü, Jiahui; Meng, Qingfan; Teng, Lirong; Wang, Di; Teng, Lesheng

doi:10.2147/ijn.s105420

Cited by 61 publications

(16 citation statements)

References 22 publications

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“…Results of erythrocyte hemolysis tests showed that when CTX concentration was 5–200 μg/mL, the erythrocyte hemolysis rate of MF-NPs-CTX and FA-PEG-NPs-CTX treatments was still less than 5%, which is in line with the standards. Encapsulation of CTX in the nanoparticles removes the strong hemolysis properties of Tween 80 and improves drug safety[25]. This result confirmed that MF-NPs-CTX and FA-PEG-NPs-CTX had good biosafety levels.…”

Section: Discussionmentioning

confidence: 61%

Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver Cabazitaxel

Meng

Sun

Lee

et al. 2019

Cancers

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Microfluidic technology (MF) has improved the formulation of nanoparticles (NPs) by achieving uniform particle size distribution, controllable particle size, and consistency. Moreover, because liquid mixing can be precisely controlled in the pores of the microfluidic chip, maintaining high mixing efficiency, MF exerts higher of NP encapsulation efficiency (EE) than conventional methods. MF-NPs-cabazitaxel (CTX) particles (MF-NPs-CTX) were first prepared by encapsulating CTX according to MF. Folate (FA)- Polyethylene glycol (PEG)-NPs-CTX particles (FA-PEG-NPs-CTX) were formulated by connecting FA to MF-NPs-CTX to endow NPs with targeted delivery capability. Accordingly, the mean particle size of FA-PEG-NPs-CTX increased by approximately 25 nm, as compared with MF-NPs-CTX. Upon morphological observation of FA-PEG-NPs-CTX and MF-NPs-CTX by transmission electron microscopy (TEM), all NPs were spherical and particle size distribution was uniform. Moreover, the increased delivery efficiency of CTX in vitro and its strong tumor inhibition in vivo indicated that FA-PEG-NPs-CTX had a powerful tumor-suppressive effect both in vitro and in vivo. In vivo imaging and pharmacokinetic data confirmed that FA-PEG-NPs-CTX had good drug delivery efficiency. Taken together, FA-PEG-NPs-CTX particles prepared using MF showed high efficient and targeted drug delivery and may have a considerable driving effect on the clinical application of targeting albumin NPs.

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Section: Discussionmentioning

confidence: 61%

Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver Cabazitaxel

Meng

Sun

Lee

et al. 2019

Cancers

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“…TP 5 -NPs were synthesized according to the previously reported method [31]. The detailed process was as follows: First, TP 5 was dissolved in 2.0 mL of anhydrous alcohol, and 1.0 mL of sodium chloride solution with a mass fraction of 12.5% and 1.0 mL of HSA were added into the above solution.…”

Section: Methodsmentioning

confidence: 99%

“…The release of TP 5 from TP 5 -NPs in vitro was determined in phosphate buffer saline (PBS, pH 7.4) containing 20.0% v / v ethanol (the solubility of free TP 5 in the release medium was 88.15 μg/mL) by dialysis method [31,32,33]. The detailed process was as follows: first, TP 5 and TP 5 -NPs were all dissolved or dispersed in 1.0 mL PBS (pH 7.4), respectively.…”

Section: Methodsmentioning

confidence: 99%

Thiophene Derivatives as Anticancer Agents and Their Delivery to Tumor Cells Using Albumin Nanoparticles

et al. 2019

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A series of thiophene derivatives (TPs) were synthesized and evaluated for cytotoxicity in HepG2 and SMMC-7721 cell lines by MTT assay. TP 5 was identified as a potential anticancer agent based on its ability to inhibit tumor cell growth. Drawbacks of TPs, including poor solubility and high toxicity, were overcome through delivery using self-assembling HSA nanoparticles (NPs). The optimum conditions for TP 5-NPs synthesis obtained by adjusting the temperature and concentration of TP 5. The NPs had an encapsulation efficiency of 99.59% and drug-loading capacity of 3.70%. TP 5 was slowly released from TP 5-NPs in vitro over 120 h. HepG2 and SMMC-7721 cell lines were employed to study cytotoxicity of TP 5-NPs, which exhibited high potency. ROS levels were elevated and mitochondrial membrane potentials reversed when the two cell lines were treated with TP 5-NPs for 12 h. Cellular uptake of fluorescence-labeled TP 5-NPs in vitro was analyzed by flow cytometry and laser confocal scanning microscopy. Fluorescence intensity increased over time, suggesting that TP 5-NPs were efficiently taken up by tumor cells. In conclusion, TP 5-NPs showed great promise as an anticancer therapeutic agent.

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“…Apt-NPs-DTX was fabricated using a modified self-assembling method that was described previously. 29 , 30 Briefly, 0.65 mL 15% disodium hydrogen phosphate was injected into 1 mL pure ethanol containing 2 mg DTX with intensive mixing. Next, 0.1 mL PBS containing 19.6 mg BSA and 0.4 mg Apt-BSA monomer was injected into this solution and incubated at 65°C for 10 min.…”

Section: Methodsmentioning

confidence: 99%

<p>Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel</p>

Yu¹,

Li²,

Duan³

et al. 2020

IJN

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Purpose Chemotherapy of colon cancer needs improvement to mitigate the severe adverse effects (AEs) associated with the cytotoxic drugs. The aim of this study is to develop a novel targeted drug delivery system (TDDS) with practical application potential for colon cancer treatment. Methods The TDDS was built by loading docetaxel (DTX) in albumin nanoparticles (NPs) that were functionalized with nucleolin-targeted aptamers (AS1411). Results The TDDS (Apt-NPs-DTX) had an average size of 62 nm and was negatively charged with a zeta potential of −31.2 mV. DTX was released from the albumin NP with a typical sustained release profile. Aptamer-guided NPs were preferentially ingested by nucleolin-expressing CT26 colon cancer cells vs the control cells. In vitro cytotoxicity study showed that Apt-NPs-DTX significantly enhanced the killing of CT26 colon cancer cells. Importantly, compared with non-targeted drug delivery, Apt-NPs-DTX treatment significantly improved antitumor efficacy and prolonged the survival of CT26-bearing mice, without raising systemic toxicity. Conclusion The results suggest that Apt-NPs-DTX has potential in the targeted treatment of colon cancer.

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Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer

Cited by 61 publications

References 22 publications

Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver Cabazitaxel

Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver Cabazitaxel

Thiophene Derivatives as Anticancer Agents and Their Delivery to Tumor Cells Using Albumin Nanoparticles

<p>Targeted Treatment of Colon Cancer with Aptamer-Guided Albumin Nanoparticles Loaded with Docetaxel</p>

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