Cabbage butterfly as bioindicator species to investigate the genotoxic effects of PM10

Macrì, Manuela; Gea, Marta; Piccini, Irene; Dessì, Luca; Santovito, Alfredo; Bonelli, Simona; Schilirò, Tiziana; Bonetta, Sara

doi:10.1007/s11356-023-25510-x

Cited by 4 publications

(1 citation statement)

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“…However, human biomonitoring remains the best approach for evaluating the effects of complex mixtures, providing data for further in vitro and in silico studies, and scientifically based risk assessment [ 72 , 73 , 74 , 75 ]. Recent studies suggest that sentinel organisms such as butterflies and plants, sensitive to air pollutants, could serve as early warning signs for human biomonitoring studies [ 76 , 77 , 78 , 79 ]. Future prospective studies should include biomarkers of air pollution exposure, human exposure conditions, and assessment of biomarkers of oxidative stress and inflammation, as these events might occur earlier in the exposure–effect scenario, forming a basis for DNA damage induction.…”

Section: Discussionmentioning

confidence: 99%

Air Pollution and Primary DNA Damage among Zagreb (Croatia) Residents: A Cross-Sectional Study

Gerić,

Pehnec,

Matković

et al. 2024

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More than eight million premature deaths annually can be attributed to air pollution, with 99% of the world’s population residing in areas below recommended air quality standards. Hence, the present study aimed to examine the association between primary DNA damage and air pollution data among 123 participants enrolled between 2011 and 2015 in Zagreb, Croatia. While most measured air pollutants adhered to regulatory limits, benzo[a]pyrene concentrations bound to PM10 exceeded them. Factorial analysis narrowed down air pollution data to four exposure factors (particulate matter, two metal factors, and other pollutants). Despite the absence of significant positive associations between modeled air pollution exposure factors and comet assay descriptors (tail length, tail intensity, tail moment, and highly damaged nuclei), the critical health implications of air pollution warrant further investigations, particularly with biomarkers of exposure and different biomarkers of effect in populations facing air pollution exposure.

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