Cabergoline, a Hopeful Medicine for Prolactinomas and Non-tumoral Hyperprolactinemia

Miki, Nobuhiro

doi:10.2169/internalmedicine.40.845

Cited by 1 publication

(1 citation statement)

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“…Cabergoline is a long-lasting, ergot derivative, selective dopamine D2 receptor agonist that has been used effectively in the treatment of both microprolactinomas and macroprolactinomas. [21][22][23]29,35,48,49,89,94 Although more expensive than bromocriptine, cabergoline is associated with less frequent and less severe side effects. This drug appears to be superior to bromocriptine in normalizing prolactin levels, restoring gonadal function, and decreasing the size of the tumor.…”

Section: Cabergoline and Other Dopamine Agonistsmentioning

confidence: 99%

Contemporary management of prolactinomas

Liu

Couldwell²

2004

FOC

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Prolactin-secreting pituitary adenomas—prolactinomas—are the most common type of functional pituitary tumor. Treatment of hyperprolactinemia is indicated because of the consequences of infertility, gonadal dysfunction, and osteoporosis. Making the correct diagnosis is important because the first line of therapy is medical management with dopamine agonists. Medical therapy is effective in normalizing prolactin levels in more than 90% of patients, but long-term treatment may be required in some patients. Transsphenoidal surgery is usually indicated in those patients in whom medical therapy fails or cannot be tolerated, or in patients who harbor microprolactinomas. In experienced hands, a hormonal and oncological cure can be achieved in more than 90% of patients after transsphenoidal removal of microprolactinomas with minimal risks. Thus, surgery may be an option for microprolactinomas in a young patient who desires restoration of fertility and avoidance of long-term medical therapy. The authors review the diagnosis and management of prolactinomas, including medical therapy, surgical therapy, and stereotactic radiosurgery.

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Section: Cabergoline and Other Dopamine Agonistsmentioning

confidence: 99%