Introduction: Periprosthetic fractures (PFs) are a main complication after total hip arthroplasty (THA), with rising incidence. The optimal treatment of PFs is still being debated in the literature. Historically, high failure and reoperation rates are reported, although the introduction of locking plates has led to improved results. In this study we report clinical and radiographic outcomes of a consecutive series of Vancouver B1 and C fractures, treated with a novel type of locking plate. We also aim to identify the variables associated with healing time. Methods: Between June 2013 and May 2019, 47 patients were consecutively admitted to the Emergency Department of our Hospital with a diagnosis of PF around a well-fixed THA stem. 31 patients fulfilled the inclusion criteria and were included in the study. All patients underwent osteosynthesis with a novel type of plate (“Ironlady” Intrauma, Rivoli, Italy) through a distally extended posterolateral approach. All surgical procedures were performed with the aim of reducing the rigidity of the fixation construct and preserving periosteal vitality. Demographic data, type of fracture, type of stem and its fixation, surgical details, and clinical and radiographical outcomes were recorded. Each variable was investigated to assess its relationship with fracture healing and healing time. Results: 31 patients were included in the study. 4 patients died before the minimum follow-up of 6 months and were excluded from the series. The final sample consisted of 27 patients. Their median age at operation was 84.8 years (range 65.3–95.4 years); 21 were female. The median follow-up after surgery was 2.36 years (range 6 months–4.7 years). In the cohort there were 22 type Vancouver B1 fractures (81.5%) and 5 type C (18.5%). All fractures occurred postoperatively (no acute intraoperative fractures). Fracture union was achieved in 26 patients (96.3%). The following variables were found to be associated with increased healing time: Vancouver type of fracture, pattern of Vancouver B1 fracture type, age and male gender. Conclusions: On the base of our results, the management of Vancouver B1 and C type of PFs by locking plate osteosynthesis appears to be a safe and effective procedure. To enhance healing and reduce complication rate, accurate surgical technique is required, aiming to implement the proximal fixation, avoid stress rising, reduce rigidity of the osteosynthesis construct and preserve the plate-to-bone gap.