Cachexia – The Interplay Between the Immune System, Brain Control and Metabolism

Štofková, Andrea

doi:10.5772/25436

Cited by 2 publications

(1 citation statement)

References 169 publications

(160 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Visfatin, in human, is expressed more in visceral adipose tissue than subcutaneous one. It is upregulated during inflammation [ 4 ]. Obesity and metabolic syndrome in children and adolescents is a leading cause of a low grade systemic inflammation [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Adipokines Vaspin and Visfatin in Obese Children

Salama

Galal

Motawie

et al. 2015

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND:Adipokines provides new insights about the physiology, pathology and treatment of obesity.AIM:We investigated the association between serum vaspin and serum visfatin concentrations with obesity in Egyptian children.MATERIAL AND METHODS:Twenty two obese children with body mass index (BMI) above 95th percentile; 11 males and 11 females were included in this study. Their mean age was 9.18 ± 2.8 years. After general clinical examination, fasting blood glucose, triglycerides, total cholesterol and high density lipoprotein cholesterol were measured in cases and controls (n=11). Fasting insulin, vaspin and visfatin were detected using ELIZA. Insulin resistance was estimated by Homeostasis model assessment method (HOMA-IR).RESULTS:Blood pressure, in both systolic and diastolic measurements was elevated significantly in obese children. Significant elevation of serum insulin and insulin resistance (HOMA/IR) were observed in obese children too. Vaspin and visfatin showed significant elevation in obese children than controls. Significant positive correlations were detected between visfatin and BMI, waist circumference, hip circumference and HOMA/IR. We found that Vaspin and visfatin are higher in obese children.CONCLUSION:Visfatin but not vaspin correlates positively with waist circumference and HOMA/IR in obese children.

show abstract

Section: Introductionmentioning

confidence: 99%

Adipokines Vaspin and Visfatin in Obese Children

Salama

Galal

Motawie

et al. 2015

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

Nutritional Supplement of Hatchery Eggshell Membrane Improves Poultry Performance and Provides Resistance against Endotoxin Stress

et al. 2016

View full text Add to dashboard Cite

Eggshells are significant part of hatchery waste which consist of calcium carbonate crust, membranes, and proteins and peptides of embryonic origins along with other entrapped contaminants including microbes. We hypothesized that using this product as a nutritional additive in poultry diet may confer better immunity to the chickens in the paradigm of mammalian milk that enhances immunity. Therefore, we investigated the effect of hatchery eggshell membranes (HESM) as a short term feed supplement on growth performance and immunity of chickens under bacterial lipopolysaccharide (LPS) challenged condition. Three studies were conducted to find the effect of HESM supplement on post hatch chickens. In the first study, the chickens were fed either a control diet or diets containing 0.5% whey protein or HESM as supplement and evaluated at 5 weeks of age using growth, hematology, clinical chemistry, plasma immunoglobulins, and corticosterone as variables. The second and third studies were done to compare the effects of LPS on control and HESM fed birds at 5 weeks of age following at 4 and 24 h of treatment where the HESM was also sterilized with ethanol to deplete bacterial factors. HESM supplement caused weight gain in 2 experiments and decreased blood corticosterone concentrations. While LPS caused a significant loss in body weight at 24 h following its administration, the HESM supplemented birds showed significantly less body weight loss compared with the control fed birds. The WBC, heterophil/lymphocyte ratio, and the levels of IgG were low in chickens fed diets with HESM supplement compared with control diet group. LPS challenge increased the expression of pro-inflammatory cytokine gene IL-6 but the HESM fed birds showed its effect curtailed, also, which also, favored the up-regulation of anti-inflammatory genes compared with control diet fed chickens. Post hatch supplementation of HESM appears to improve performance, modulate immunity, and increase resistance of chickens to endotoxin.

show abstract

Cachexia – The Interplay Between the Immune System, Brain Control and Metabolism

Cited by 2 publications

References 169 publications

Adipokines Vaspin and Visfatin in Obese Children

Adipokines Vaspin and Visfatin in Obese Children

Nutritional Supplement of Hatchery Eggshell Membrane Improves Poultry Performance and Provides Resistance against Endotoxin Stress

Contact Info

Product

Resources

About