CaCO3-assistant synthesis of pH/near-infrared light-responsive and injectable sodium alginate hydrogels for melanoma synergistic treatment

Advances in NIR-Responsive Natural Macromolecular Hydrogel Assembly Drugs for Cancer Treatment

“…Hydrogel-based drug delivery systems, as a platform, can enhance the efficacy and reduce the toxicity of chemotherapy agents while achieving phototherapy to solve the limitations of chemotherapy. Researchers encapsulated doxorubicin in a hyaluronic acid hydrogel, regulating the release of chemotherapy drugs by stimulating hydrogel cross-linking through the ROS generated by ICG [ 132 ]. Yuan Cao et al designed a GO-Fe 3 O 4 nanomaterial composed of Go embedded in an interpenetrating polymer to improve the performance of a poly(n-isopropylacrylamide) (PNIPAM) hydrogel under the action of near-infrared light and alternating magnetic fields.…”

“…PpIX ROS is produced to kill tumors, and ROS prodrug release is stimulated to enhance anti-tumor immunity [131] ROS was generated to achieve local PDT treatment, and hydrogel cross-linking was induced to achieve drug release under NIR regulation [132] T1-PPa Two-photon infrared light irradiation improves the depth of light penetration and prevents Ps aggregation [121] PDT in combination with IT for colon Chemotherapy (CT) is a systemic treatment method that uses chemical drugs to prevent cancer cell proliferation, invasion and metastasis until the cells are eventually killed. The commonly used chemotherapy drugs can be divided into tisanes (paclitaxel, albumin-paclitaxel, docetaxel), antibiotics (doxorubicin) and antimetabolites (fluorouracil, methotrexate).…”

“…PpIX ROS is produced to kill tumors, and ROS prodrug release is stimulated to enhance anti-tumor immunity [131] ROS was generated to achieve local PDT treatment, and hydrogel cross-linking was induced to achieve drug release under NIR regulation [132] T1-PPa Two-photon infrared light irradiation improves the depth of light penetration and prevents Ps aggregation [121] ICG PDT in combination with IT for colon cancer; the production of large amounts of ROS and the production of NO inhibit the proliferation of cancer cells [122] UZC@HA Targeted therapy, without damage to normal tissues, induces the apoptosis of breast-cancer-related cells [123] Currently, researchers are seeking more ideal chemotherapy methods, such as using ferroptosis or designing different types of prodrugs to achieve treatment goals, and designing ideal drug delivery systems based on different materials to achieve the release of chemotherapy drugs and reduce the damage of chemotherapy drugs to the human body. Hydrogel-based drug delivery systems, as a platform, can enhance the efficacy and reduce the toxicity of chemotherapy agents while achieving phototherapy to solve the limitations of chemotherapy.…”

Composite Nanoplatforms Based on Nanocalcium Peroxide for Cancer Treatment: From Monotherapy to Combination Therapy

“…As such, understanding intracellular calcium ion homeostasis has become a focal point of antitumor research. [83,84] Disruption of intracellular calcium homeostasis can lead to severe oxidative stress, resulting in cell necrosis, apoptosis, or autophagy-mediated cell death. Therefore, the accumulation of free Ca 2+ in cells represents a critical point of concern, as it can result in calcium overload and the subsequent injury or death of various cell types.…”

Biomineralized Polydopamine Nanoparticle-Based Sodium Alginate Hydrogels for Delivery of Anti-serine/Threonine Protein Kinase B-Rapidly Accelerated Fibrosarcoma siRNA for Metastatic Melanoma Therapy

“…When injected, the hydrogels form a depot at the tumor sites, providing controlled and sustained drug release that is localized to the tumor microenvironment . Especially, the combination of injectable hydrogels and photothermal therapy (PTT) offers a promising treatment strategy for melanoma. , By incorporating light-absorbing agents into injectable hydrogels, PTT can achieve excellent antitumor effects by generating heat in response to laser irradiation, leading to localized tumor necrosis . This delivery system endows the PTT with the maximum efficiency while minimizing damage to healthy tissue.…”