Cadaver study of the volume of the ovary in Bangladeshi women

Perven, Hosna Ara; Nurunnabi, Abu Sadat Mohammad; Ara, Shamim; Jahan, Munira

doi:10.3329/bmrcb.v40i1.20323

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…Average right-left differences have ranged from 0.5-1.6 mL (26,27,29,34,41), with one study (26) reporting an upper limit of agreement near 5.0 mL. Evidence that the right ovary is larger than the left ovary across the lifespan, from childhood (42) through the fourth decade (27,29) and postmortem (43), increases confidence in our findings. Differences in blood supply between the two ovaries could offer a physiological basis for one being larger-albeit studies (26,34,41,44,45) using Doppler ultrasound technology have yielded conflicting data on right-left differences in vascular indices, independent of gravidity or parity.…”

Section: Discussionsupporting

confidence: 60%

Impact of right–left differences in ovarian morphology on the ultrasound diagnosis of polycystic ovary syndrome

Jarrett

Brink

Brooks

et al. 2019

Fertility and Sterility

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Section: Discussionsupporting

confidence: 60%

Impact of right–left differences in ovarian morphology on the ultrasound diagnosis of polycystic ovary syndrome

Jarrett

Brink

Brooks

et al. 2019

Fertility and Sterility

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“…When data are interpreted, it should also be kept in mind that ovarian volume and ovarian surface area are smaller during childhood and at the end of the reproductive phase, which means that the total number of follicles can only be deduced to a limited extent from the cortical FD. Thus, ovarian volume changes with age (Orsini et al, 1984;Cohen et al, 1993;Goldberg and McGahan, 2006;Perven et al, 2014;El Issaoui et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The maximum ovarian volume is reached in young adults (8-14 cm 3 ) and declines thereafter. In a cadaver study the average ovary size in females aged 14-45 years was determined as 5.95 ± 1.37 cm 3 (right ovary) and 4.24 ± 1.05 cm 3 (left ovary) (Perven et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases—implications in fertility preservation

Liebenthron

Reinsberg

Ven³

et al. 2019

Human Reproduction

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STUDY QUESTION How do anti-Müllerian hormone (AMH) serum concentrations and follicle densities (FDs) change with age and disease and what are the implications for fertility preservation? SUMMARY ANSWER AMH concentrations and FD do not correlate in young women, and AMH but not FD is reduced in some diseases, limiting the value of AMH as a predictive parameter of ovarian tissue transplantation. WHAT IS KNOWN ALREADY AMH is widely used as a parameter to estimate the ovarian reserve. However, the reliability of AMH to predict total number of follicles and the FD is questionable. Women with lymphoma and leukaemia have been shown to have reduced AMH concentrations, but it is unknown if the FD is also reduced. In fertility preservation it is essential to estimate the correct total number of follicles and the FD, as ovarian tissue should only be cryopreserved if ovarian reserve is high. Furthermore, the amount of tissue to be transplanted should be based on the estimation of the real FD. STUDY DESIGN, SIZE, DURATION This retrospective observational study included 830 women (mean ± SD age, 28.2 ± 6.81 years; range, 4–43 years) with malignant (n = 806) and benign (n = 24) diseases who cryopreserved tissue in a single centre as part of a national fertility preservation programme. Females with ovarian surgery or known predispositions for a reduced ovarian reserve were excluded. AMH concentrations and FD were evaluated from March 2011 to September 2016. PARTICIPANTS/MATERIALS, SETTING, METHODS AMH concentrations were analysed before gonadotoxic therapies. Standardized biopsies, obtained from different areas of ovarian cortex, were collected. FD was analysed after tissue digestion and calcein staining and was expressed as average number of primordial and primary follicles count per 3 mm biopsy and per cubic millimeter tissue. AMH concentrations and FD were analysed in relation to age and diagnosis group. Both parameters were age adjusted, and associations between the different diagnosis groups and AMH versus FD were assessed. MAIN RESULTS AND THE ROLE OF CHANCE Mean ± SD AMH concentration was 3.1 ± 2.81 g/ml, mean FD per 3 mm biopsy was 137 ± 173.9 and 19.4 ± 24.60 per mm3. Maximum AMH concentrations were found in children and teenagers at the age of 6–10 years (5.71 ng/ml) and in adults at the age of 21–25 years (3.33 ng/ml). FD was highest in young children up to an age of 15 years and decreased with increasing age. AMH and FD were not correlated in women ≤20 years and weakly to moderately correlated in women 21–40 years (r = 0.24–0.39). Age-adjusted correlations between AMH and FD were demonstrated in several diagnosis groups such as breast cancer, leukaemia, sarcoma, gastrointestinal cancer and gynaecological cancer but not in the groups exhibiting Hodgkin’s and non-Hodgkin’s lymphoma, cerebral cancer, other types of malignancies and other types of benign diseases. Further statistical analysis supported the finding that, in some diagnosis groups such as Hodgkin’s lymphoma and in gynaecological cancer, AMH concentrations but not FDs are reduced, questioning the prognostic accuracy of AMH for the FD in these diseases. LIMITATIONS, REASONS FOR CAUTION Even though biopsies were taken from different sites, heterogenous distribution of follicles might have had some effect on the accuracy of the analysis. WIDER IMPLICATION OF THE FINDINGS AMH should be used with care to estimate the total ovarian reserve and FD of cancer patients in young women in some diseases. Therefore, calculating the amount of ovarian tissue to be transplanted based solely on AMH might be inaccurate whereas FD might be a better parameter. STUDY FUNDING/COMPETING INTEREST(S) The study did not receive any exterior funding.

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“…Perven at al. conducted a post-mortem study of human ovaries in the specific ethnic group of Bangladeshi women and found that the weight of right ovaries was significantly greater, compared to the left side [ 30 ]. As expected, the ovarian weight was significantly lower in the subgroup of women aged over 45 years.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Morphometric and Histologic Characteristics and Correlation with Clinical Factors: A Cross-Sectional Study

Giovannopoulou

Karakasi

Kouroupi

et al. 2023

JPM

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Reproductive lifespan is determined by the reserve of ovarian follicles; their quality and quality determine the fertility potential at a given point in time for a particular individual. Inter-individual variations related to morphometry, laterality, medical history, demographic characteristics and ethnicity may impact ovarian histology, which however, has not been extensively studied or documented. The present cross-sectional study aims to investigate the potential association of clinical factors (age, medical and obstetric history) with ovarian morphometry and histology in females of reproductive age in the local population. The sample included 31 specimens of whole human ovaries, obtained from surgical/autopsy procedures in reproductive-aged women, processed at the Pathology Department. Morphometric characteristics were assessed, including shape, color, length, width, thickness and gross ovarian pathology. Random samples of specific dimensions were histologically examined to determine follicular counts. The results were analyzed statistically in correlation to morphometric characteristics and medical history. The majority of the patients had oval-shaped ovaries (77.8% right; 92.3% left; p = 0.368) of whitish color (38.9% right; 46.2% left; p > 0.999). Right ovaries had significantly greater length, width and volume (p-values 0.018, 0.040 and 0.050, respectively). Thickness was equivalent, as well as follicular distribution of all classes. Age correlated inversely with ovarian volume and primordial/primary follicular count on histology. Women with a caesarian-section history yielded significantly lower primordial/primary follicular counts. As estimated by ovarian histology, macroscopic and clinical factors may be significantly associated with actual ovarian reserve.

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Cadaver study of the volume of the ovary in Bangladeshi women

Abstract: Reproductive age, ovarian reserve and reproductive capability may be determined from the volume of the ovary. A cross-sectional, descriptive study was done in the

Cited by 5 publications

References 20 publications

Impact of right–left differences in ovarian morphology on the ultrasound diagnosis of polycystic ovary syndrome

Impact of right–left differences in ovarian morphology on the ultrasound diagnosis of polycystic ovary syndrome

Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases—implications in fertility preservation

Ovarian Morphometric and Histologic Characteristics and Correlation with Clinical Factors: A Cross-Sectional Study

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