Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns

Abstract

BackgroundIn January 2005, Rasulov et al. originally published “First experience in the use of bone marrow mesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns”. Here, we present the first ever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine.MethodsA young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns while working with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow of a cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry of Health, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after early escharotomy.ResultsSo far, our preliminary experience and our early results have been very impressive showing an outstanding safety data as well as some impressive good results in the use of CMSCs.ConclusionsBased on all this, we think that improvements in the use of stem cells for burns might be possible in the near future and a lot of time as well as many lives could be saved by many other research teams all over the world. CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation.

Efficacy assessment of mesenchymal stem cell transplantation for burn wounds in animals: a systematic review

“…Currently, a series of clinical trials (1 allogenic MSC, 1 cadaveric MSC, 1 bone marrow MSC) and a casecontrol prospective study (bone marrow MSC = 20, umbilical cord-MSC = 20, EE&G = 20) investigating the efficacy and safety of stem cell therapy have been completed. The results demonstrate that MSCs can effectively promote burn wound healing and are considered safe and effective, with great therapeutic potential for patients with severe burns [20][21][22][23]. However, to date, there has been no systematic and comprehensive preclinical analysis of stem cell therapy for burn wounds, and the integration of these preclinical data can offset knowledge gaps that may affect the future application of stem cells.…”

Does the transplantation of keratinocytes really reduce the risk of death? Survival analysis of patients hospitalized at the Dr Stanisław Sakiel Centre for Burns Treatment in 2008–2015

“…31 In the case of extensive, deep burns (3 rd degree), the use of stem cells is recommended. 32,33 At present, we can agree that the CEA transplant is a life-saving, but expensive procedure, unsuitable for the permanent coverage of burn wounds deeper than the 2 nd degree. 34 Matters related to the optimal donor site selection for cell culture purposes, wound dressing applied to the wound before harvesting the donor skin for the culture and post-cell transplantation, and, most importantly, an informed choice of the group of patients for whom applying keratinocytes will give a maximum clinical effect, should have all been systematized many years ago.…”

Function and Therapeutic Potential of Mesenchymal Stem Cells and Their Acellular Derivatives on Non-Healing Chronic Skin Ulcers

“…To surmount the barriers associated with MSC precedence and isolation procedures, the use of cadaveric MSCs (CMSCs) from BM has recently emerged as a new approach. Mansilla and coworkers were the first research group that reported the use of CMSCs for treating severe thermal burns in a 26-year old male patient [24]. After isolation and expansion of CMSCs, combined treatment (conventional and CMSCs) was administered to the patient, who did not have any immunological rejection and was monitored during 35 days.…”