Cadherin is required for dendritic morphogenesis and synaptic terminal organization of retinal horizontal cells

Tanabe, Koji; Takahashi, Yoshiko; Sato, Yuki; Kawakami, Koichi; Takeichi, Masatoshi; Nakagawa, Shinichi

doi:10.1242/dev.02566

Cited by 62 publications

(48 citation statements)

References 55 publications

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“…N-cadherin mediates neurite elongation, as shown by in vitro (35,204,356) as well as in vivo (202,284,342) studies. Neurite outgrowth activity was also reported for R-cadherin, E-cadherin, cadherin 7, and cadherin 11 (14,28,40,240,241,278).…”

Section: Neurite Elongation and Branchingmentioning

confidence: 87%

“…For example, in retinal horizontal cells, N-cadherin defines the dendritic field size through the control of the attachment of their dendritic processes to photoreceptor cells (342). Ncadherin is also important for CA3 dendrite arborization in the hippocampus (30).…”

Section: Neurite Elongation and Branchingmentioning

confidence: 99%

“…The N-cadherin-␤-catenin complexes bind to an AMPA receptor (GluR2/3) (81, 239), and this association restricts the lateral diffusion of GluR2 (239,291). Accumulation of GluR4 is blocked by inhibition of cadherins in the retina (342).…”

Section: Synapse Differentiation and Signalingmentioning

confidence: 99%

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Cadherins in Brain Morphogenesis and Wiring

Hirano

Takeichi

2012

Physiological Reviews

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274

312

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LHirano S, Takeichi M. Cadherins in Brain Morphogenesis and Wiring. Physiol Rev 92: 597-634, 2012; doi:10.1152/physrev.00014.2011 -dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis. Various cadherin-related molecules have also been identified, which show diverse functions, not only for the regulation of cell adhesion but also for that of cell proliferation and planar cell polarity. During the past decade, understanding of the roles of these molecules in the nervous system has significantly progressed. They are important not only for the development of the nervous system but also for its functions and, in turn, for neural disorders. In this review, we discuss the roles of cadherins and related molecules in neural development and function in the vertebrate brain.

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Section: Neurite Elongation and Branchingmentioning

confidence: 87%

Section: Neurite Elongation and Branchingmentioning

confidence: 99%

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Cadherins in Brain Morphogenesis and Wiring

Hirano

Takeichi

2012

Physiological Reviews

Self Cite

274

312

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“…To date, a few glycoproteins have been identified that play structural roles in triad synapses, such as dystrophin (Pilgram et al, 2010), retinoschisin (Johnson et al, 1996), and pikachurin (Sato et al, 2008), but these proteins are synthesized by either photoreceptors or bipolar cells. However, in chick horizontal cells, N-cadherin is required for dendrite morphogenesis and subsequent synapse formation with photoreceptor cells (Tanabe et al, 2006). Whether N-cadherin also plays a role in synapse maintenance remains to be seen.…”

Section: Discussionmentioning

confidence: 99%

Ablation of Retinal Horizontal Cells from Adult Mice Leads to Rod Degeneration and Remodeling in the Outer Retina

Sonntag

Dedek²,

Dorgau³

et al. 2012

Journal of Neuroscience

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In the brain, including the retina, interneurons show an enormous structural and functional diversity. Retinal horizontal cells represent a class of interneurons that form triad synapses with photoreceptors and ON bipolar cells. At this first retinal synapse, horizontal cells modulate signal transmission from photoreceptors to bipolar cells by feedback and feedforward inhibition. To test how the fully developed retina reacts to the specific loss of horizontal cells, these interneurons were specifically ablated from adult mice using the diphtheria toxin (DT)/DT-receptor system and the connexin57 promoter. Following ablation, the retinal network responded with extensive remodeling: rods retracted their axons from the outer plexiform layer and partially degenerated, whereas cones survived. Cone pedicles remained in the outer plexiform layer and preserved synaptic contacts with OFF but not with ON bipolar cells. Consistently, the retinal ON pathway was impaired, leading to reduced amplitudes and prolonged latencies in electroretinograms. However, ganglion cell responses showed only slight changes in time course, presumably because ON bipolar cells formed multiple ectopic synapses with photoreceptors, and visual performance, assessed with an optomotor system, was only mildly affected. Thus, the loss of an entire interneuron class can be largely compensated even by the adult retinal network.

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“…Xenopus retinal ganglion cells expressing a dominant negative N-cadherin fail to generate dendrites (Riehl et al, 1996), and chick horizontal cells show reduced arbor size (Tanabe et al, 2006). N-cadherin promotes dendritic outgrowth in hippocampal neurons (Esch et al, 2000), zebrafish amacrine cells require N-cadherin to arborize appropriately (Masai et al, 2003), and DN-cadherin restricts dendritic arbors that are generated by olfactory projection neurons in Drosophila (Zhu and Luo, 2004).…”

Section: Cadherins and Dendritic Arborsmentioning

confidence: 99%

Cadherin‐8 and N‐cadherin differentially regulate pre‐ and postsynaptic development of the hippocampal mossy fiber pathway

et al. 2007

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Cells sort into regions and groups in part by their selective surface expression of particular classic cadherins during development. In the nervous system, cadherin-based sorting can define axon tracts, restrict axonal and dendritic arbors to particular regions or layers, and may encode certain aspects of synapse specificity. The underlying model has been that afferents and their targets hold in common the expression of a particular cadherin, thereby providing a recognition code of homophilic cadherin binding. However, most neurons express multiple cadherins, and it is not clear whether multiple cadherins all act similarly in shaping neural circuitry. Here we asked how two such cadherins, cadherin-8 and N-cadherin, influence the guidance and differentiation of hippocampal mossy fibers. Using organotypic hippocampal cultures, we find that cadherin-8 regulates mossy fiber fasciculation and targeting, but has little effect on CA3 dendrites. In contrast, N-cadherin regulates mossy fiber fasciculation, but has little impact on axonal growth and targeting. However, N-cadherin is essential for CA3 dendrite arborization. Both cadherins are required for formation of proper numbers of presynaptic terminals. Mechanistically, such differential actions of these two cadherins could, in theory, reflect coupling to distinct intracellular binding partners. However, we find that both cadherins bind b-catenin in dentate gyrus (DG). This suggests that cadherins may engage different intracellular signaling cascades downstream of b-catenin, coopt different extracellular binding partners, or target distinct subcellular domains. Together our findings demonstrate that cadherin-8 and N-cadherin are critical for generating the mossy fiber pathway, but that each contributes differentially to afferent and target differentiation, thereby complementing one another in the assembly of a synaptic circuit.

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Cadherin is required for dendritic morphogenesis and synaptic terminal organization of retinal horizontal cells

Cited by 62 publications

References 55 publications

Cadherins in Brain Morphogenesis and Wiring

Cadherins in Brain Morphogenesis and Wiring

Ablation of Retinal Horizontal Cells from Adult Mice Leads to Rod Degeneration and Remodeling in the Outer Retina

Cadherin‐8 and N‐cadherin differentially regulate pre‐ and postsynaptic development of the hippocampal mossy fiber pathway

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