Cadherins as Central Modulators of Wound Repair

Cell Adhesion Molecules Are Mediated by Photobiomodulation at 660 nm in Diabetic Wounded Fibroblast Cells

“…Their main function is to stimulate cell-cell and cell-matrix adhesion. They are also responsible for cell proliferation, differentiation, migration, survival and gene expression [ 13 ]. Integrins are heterodimeric transmembrane proteins that play important roles during developmental and pathological processes, including cell proliferation, differentiation, cell-cell attachment, adhesion and signal transduction between the cell and ECM [ 14 ].…”

Understanding the complications of pseudomonas aeruginosa biofilm exudates on wound healing

“…Cadherins are also important in re-epithelialisation. Adherens junctions are needed for cell-cell adhesion along the leading edge, but a downregulation of E-cadherin is also observed in migrating keratinocytes, resulting in the dissolution of these junctions so that wound repair can occur (Crawford and Dagnino, 2018). E-cadherin is also involved in Rac1 activation at the cell front, while P-cadherin is involved in Cdc42 activation at the rear in collective cell migration in re-epithelialisation (Cai et al, 2014;Plutoni et al, 2016).…”