Cadmium: a new risk factor for endometrial cancer?

McElroy, Jane A.; Hunter, Mark

doi:10.1080/14737140.2019.1596029

Cited by 16 publications

(4 citation statements)

References 38 publications

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“…Other types of cancer found to be associated with Cd exposure were endometrial cancer [117], acute myeloid leukemia [118], urinary bladder cancer [119], oral and gastrointestinal carcinomas [120,121], and nasopharyngeal and pharyngeal cancers [122].…”

Section: Cadmium and Other Types Of Cancermentioning

confidence: 99%

Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium

Cirovic,

Satarug

2024

IJMS

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Cadmium (Cd) is an environmental toxicant of worldwide public health significance. Diet is the main non-workplace Cd exposure source other than passive and active smoking. The intestinal absorption of Cd involves transporters for essential metals, notably iron and zinc. These transporters determine the Cd body burden because only a minuscule amount of Cd can be excreted each day. The International Agency for Research on Cancer listed Cd as a human lung carcinogen, but the current evidence suggests that the effects of Cd on cancer risk extend beyond the lung. A two-year bioassay demonstrated that Cd caused neoplasms in multiple tissues of mice. Also, several non-tumorigenic human cells transformed to malignant cells when they were exposed to a sublethal dose of Cd for a prolonged time. Cd does not directly damage DNA, but it influences gene expression through interactions with essential metals and various proteins. The present review highlights the epidemiological studies that connect an enhanced risk of various neoplastic diseases to chronic exposure to environmental Cd. Special emphasis is given to the impact of body iron stores on the absorption of Cd, and its implications for breast cancer prevention in highly susceptible groups of women. Resistance to cell death and other cancer phenotypes acquired during Cd-induced cancer cell transformation, under in vitro conditions, are briefly discussed. The potential role for the ZnT1 efflux transporter in the cellular acquisition of tolerance to Cd cytotoxicity is highlighted.

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Section: Cadmium and Other Types Of Cancermentioning

confidence: 99%

Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium

Cirovic,

Satarug

2024

IJMS

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“…Although existing data is inadequate, particularly for EC, hormone-dependent cancers may be more prone to estrogen-mimicking substances such as Cd [10]. Recent studies have indicated that Cd causes adipose tissue malfunction and insulin resistance causing elevated risk of obesity which is a predisposing factor to EC [16]. Exogenous estrogen exposure, such as from plant estrogens or hormone-based medications, can also increase the risk of EC [14].…”

Section: Cadmium and Endometrial Cancermentioning

confidence: 99%

“…EC has a significantly growing prevalence associated with excess weight gain and aging [14] as epidemiological research has revealed that an excess of body weight is responsible for > or = 40% of its prevalence [15], and countries within North America and Europe have a ten times higher rate of occurrence in contrast to less advanced countries [13]. Although the exact cause of EC is not known [2], the expected rise in the incidence rates [16] may be influenced by a combination of obesity [17], diabetes mellitus and cadmium exposure [18], which are major risk factors. The development of EC can be influenced by a variety of factors and a multidisciplinary evaluation of these factors is helpful in predicting the extent of risk that an individual is predisposed to.…”

Section: Introduction 1endometrial Cancer: a Disease Of Public Heath ...mentioning

confidence: 99%

Cadmium, Lead, Chronic Physiological Stress and Endometrial Cancer: How Environmental Policy Can Alter the Exposure of At-Risk Women in the United States

Olarewaju

Obeng-Gyasi

2023

Healthcare

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The health and life outcomes of individuals are intertwined with the context in which they grow and live. The totality of exposures one experiences affects health in the short term and throughout the life course. Environmental exposure to multiple contaminants can increase stress levels in individuals and neighborhoods with psychosocial stressors such as crime, drug and alcohol misuse, and violence also taking a toll on individual and neighborhood wellbeing. In addition, the availability, organization, and quality of local institutions and infrastructure all affect health in the short and long term. The role of these factors in endometrial cancer will be explored in this paper. In addition, policy implications regarding lead, chronic physiological stress, and endometrial cancer will be explored to ascertain the impact of these factors on at-risk women.

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“…This is associated with the risk of a widespread deficiency of this micronutrient, which, as mentioned above, leads to reduced selenoprotein activity and a possible increased risk of developing some malignant neoplasms. In recent years, selenium, like other micronutrients (copper, zinc, iron, cadmium), has aroused increasing interest due to its potential role in carcinogenesis [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. There is well-documented evidence of a variety of selenium anticancer activity, related both to the function of selenoproteins and the action of selenium and its metabolites in the human body.…”

Section: Introductionmentioning

confidence: 99%

An Assessment of Serum Selenium Concentration in Women with Ovarian Cancer

et al. 2023

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Background: Available studies on the effect of serum selenium levels on the risk of malignancies show some conflicting results. In this study, we investigated the correlation between serum selenium levels and ovarian cancer occurrence. Methods: 314 women (157 diseased patients and 157 healthy ones) matched in terms of age and BMI were included in the study. The measurements of selenium in the collected blood samples were performed using an ICP mass spectrometer. Univariable and multivariable analyzes were performed to determine the relationship between the factors under the study and the occurrence of ovarian cancer. Results: The mean concentration of selenium was lower among diseased ones than among controls (53.31 μg/L vs. 78.99 μg/L). A decrease in selenium concentration was noticed with the advancement of ovarian cancer. In univariable and multivariable analyzes, a clear relationship between low selenium concentration and the occurrence of ovarian cancer was found (35.3 (95% CI: 11.2–111; p < 0.001) and 45.8 (95% CI: 12.8–164; p < 0.001)). Conclusion: The studied patients with ovarian cancer are characterized by statistically significant lower serum selenium levels than patients from the control group. Among the study group, a decrease in selenium concentration was observed with an increase in the FIGO stage. The determination of the role of selenium as a prophylactic factor in ovarian cancer requires further prospective studies.

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Cadmium: a new risk factor for endometrial cancer?

Cited by 16 publications

References 38 publications

Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium

Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium

Cadmium, Lead, Chronic Physiological Stress and Endometrial Cancer: How Environmental Policy Can Alter the Exposure of At-Risk Women in the United States

An Assessment of Serum Selenium Concentration in Women with Ovarian Cancer

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