Cadmium and cardiovascular disease: An overview of pathophysiology, epidemiology, therapy, and predictive value

Lin, Hung-Chen; Hao, Weiming; Chu, Pao‐Hsien

doi:10.1016/j.repc.2021.01.009

Cited by 45 publications

(20 citation statements)

References 59 publications

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“…The measurements of the markers of oxidative-reductive status and inflammation showed that moderate and relatively high intoxication with this heavy metal led to the development of oxidative stress and stimulated inflammatory processes in the vascular tissue. Oxidative stress and inflammation are considered to be the potential common etiological factors of cardiovascular disorders [ 20 , 23 , 24 , 26 , 27 , 29 , 41 , 42 ]. Cd may induce the excessive formation of reactive oxygen species (ROS) and free radicals (FR) by, e.g., decreasing the activity of antioxidative enzymes (including Zn-dependent superoxide dismutase—SOD) and the concentration of non-enzymatic antioxidants (including reduced glutathione—GSH) and induction of the activity of oxidases, and dysfunction of mitochondria [ 8 , 9 , 23 , 28 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…The accumulation of Cd in the environment and outcomes of lifetime exposure to this xenobiotic are among the most disturbing ecological and health issues in industrialized countries [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Chronic, even low-level, intoxication with this trace element may lead to damage to the kidney, liver, and skeleton, as well as increase the risk of neurodegenerative diseases and cancer [ 12 , 13 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Chronic, even low-level, intoxication with this trace element may lead to damage to the kidney, liver, and skeleton, as well as increase the risk of neurodegenerative diseases and cancer [ 12 , 13 , 15 , 16 ]. Moreover, it may result in severe cardiovascular pathologies (atherosclerosis, stroke, hypertension, and impaired heart function) and increase cardiovascular mortality [ 12 , 17 , 18 , 19 , 20 , 21 ]. The endothelial cells are considered to be the main target for the toxic action of Cd on the blood vessels [ 20 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, it may result in severe cardiovascular pathologies (atherosclerosis, stroke, hypertension, and impaired heart function) and increase cardiovascular mortality [ 12 , 17 , 18 , 19 , 20 , 21 ]. The endothelial cells are considered to be the main target for the toxic action of Cd on the blood vessels [ 20 , 22 , 23 , 24 ]. Experimental data have revealed that this xenobiotic may be the cause of the dysfunction and death of the endothelial cells, followed by alterations in the endothelial integrity and vascular damage [ 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

“…The endothelial cells are considered to be the main target for the toxic action of Cd on the blood vessels [ 20 , 22 , 23 , 24 ]. Experimental data have revealed that this xenobiotic may be the cause of the dysfunction and death of the endothelial cells, followed by alterations in the endothelial integrity and vascular damage [ 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. However, the mechanisms of the injury of the vessels due to the intoxication with Cd comparable to human exposure have not been studied yet.…”

Section: Introductionmentioning

confidence: 99%

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The Beneficial Impact of Zinc Supplementation on the Vascular Tissue of the Abdominal Aorta under Repeated Intoxication with Cadmium: A Study in an In Vivo Experimental Model

2022

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In an in vivo rat model of human exposure to cadmium (Cd; 5 and 50 mg/L, 6 months), whether the supplementation with zinc (Zn; 30 and 60 mg/L, increasing its daily intake by 79% and 151%, respectively) protects against the unfavourable impact of this xenobiotic on the vascular tissue of the abdominal aorta was investigated. The treatment with Cd led to oxidative stress and increased the concentrations of pro-inflammatory interleukin 1β (IL-1β), total cholesterol (TC), triglycerides (TG), and endothelial nitric oxide synthase (eNOS) and decreased the concentration of anti-inflammatory interleukin 10 (IL-10) in the vascular tissue. Cd decreased the expression of intercellular adhesion molecule-1 (ICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM-1), and L-selectin on the endothelial cells. The administration of Zn prevented most of the Cd-induced alterations or at least weakened them (except for the expression of adhesive molecules). In conclusion, Zn supplementation may protect from the toxic impact of Cd on the blood vessels and thus exert a beneficial influence on the cardiovascular system. The increase in the intake of Zn by 79% may be sufficient to provide this protection and the effect is related to the antioxidative, anti-inflammatory, and antiatherogenic properties of this essential element.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Beneficial Impact of Zinc Supplementation on the Vascular Tissue of the Abdominal Aorta under Repeated Intoxication with Cadmium: A Study in an In Vivo Experimental Model

2022

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Magnetic Dispersive Solid‐Phase Extraction Using Toner Powder for Trace Determination of Heavy Metals in Vegetables and Aqueous Media by FAAS: Box‐Behnken Design

et al. 2022

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In this work, toner powder as a magnetic adsorbent coupled with a dispersive solid phase extraction (DSPE) method was proposed for the pre‐concentration and separation of Pb2+, Cd2+, and Zn2+ in vegetable samples and aqueous environments. Flame atomic absorption spectrometry (FAAS) was used for the final analysis of the ions. Adsorbent characterization was studied by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier‐transform infrared spectroscopy (FTIR), X‐ray diffraction analysis (XRD), and vibrating‐sample magnetometer (VSM). The effect of experimental factors on the extraction efficiency was investigated by Box‐Behnken design (BBD). The maximum recovery percentage was found to be 95.40%, 95.40%, and 97.40% for Pb2+, Cd2+, and Zn2+, respectively. In the optimum conditions, the linearity ranges were obtained 12–200, 1–150, 0.4–100 μg L−1 for the Pb, Cd, and Zn ions, respectively. The limit of detection (LOD) of the method was found 3.60, 0.30, and 0.11 μg L−1 for the Pb2+, Cd2+, and Zn2+, respectively. The suggested procedure indicated to be appropriate, cost‐effective, and eco‐friendly for extraction of mentioned metal ions in different vegetables and water samples with high precision and accuracy.

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Human Health Effects of Chronic Cadmium Exposure

Zuhra,

Akhtar,

Yasin

et al. 2024

Cadmium Toxicity Mitigation

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Cadmium and cardiovascular disease: An overview of pathophysiology, epidemiology, therapy, and predictive value

Cited by 45 publications

References 59 publications

The Beneficial Impact of Zinc Supplementation on the Vascular Tissue of the Abdominal Aorta under Repeated Intoxication with Cadmium: A Study in an In Vivo Experimental Model

The Beneficial Impact of Zinc Supplementation on the Vascular Tissue of the Abdominal Aorta under Repeated Intoxication with Cadmium: A Study in an In Vivo Experimental Model

Magnetic Dispersive Solid‐Phase Extraction Using Toner Powder for Trace Determination of Heavy Metals in Vegetables and Aqueous Media by FAAS: Box‐Behnken Design

Human Health Effects of Chronic Cadmium Exposure

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