Cadmium and Selenium Interaction in Mammals

Lazarus, Maja

doi:10.2478/10004-1254-61-2010-2021

Cited by 15 publications

(14 citation statements)

References 119 publications

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“…The relation was more pronounced in muscle and kidney than in liver tissues (Table 4). Selenium and Cd interaction reported in laboratory mammal experiments and human studies (reviews) [5,10] were confirmed in studies on polar bears, bowhead and beluga whales, red deer, [12,32] but were not found in ringed seals, arctic foxes and wolverines, [12,54] regardless of the high Cd burden similar to the one in our study. Our finding that most bears had molar Se/Cd ratios in liver and kidney under or equal to unity ( Table 1) may imply that Se levels, although in excess compared to Hg, were yet insufficient to detoxify more abundant tissue Cd by means of binding to the complex.…”

Section: Relations Between Selenium Cadmium and Mercurysupporting

confidence: 65%

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Selenium in brown bears (Ursus arctos) from Croatia: Relation to cadmium and mercury

Lazarus

Sekovanić

Reljić

et al. 2014

Journal of Environmental Science and Health, Part A

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Muscle (n = 111), liver (n = 111), and kidney cortex (n = 101) samples from brown bears (Ursus arctos) were collected in the 2009 and 2010 hunting seasons in Croatia and analysed for selenium (Se), cadmium (Cd), and total mercury (Hg). The aim was to assess the levels of these elements according to age, sex, and season of collection, and to investigate possible Se/Cd and Se/Hg interactions. Median Se concentrations were 0.139 μg/g in muscle, 0.409 μg/g in liver and 1.75 μg/g wet mass in kidney cortex. Median Cd and Hg were 0.0078 and 0.0018 μg/g in muscle, 1.09 and 0.031 μg/g in liver, and 16.5 and 0.206 μg/g wet mass in the renal cortex, respectively. Se/Cd molar ratios were less than 1 in the kidney cortex, and close to or above 1 in liver and muscle, respectively. Toxic Cd and Hg correlated with Se in all of the studied tissues. Sex differences were found for all three elements (except Se in liver), with females having higher tissue concentration than males. Only Cd showed age-dependence. Bear samples collected in fall had higher Se in muscles, and Hg in muscles and liver compared to samples collected in spring. Element concentrations in brown bear tissues were within the range of previously reported studies. Bear meat is considered a rich source of Se, safe for consumption with regard to its Cd and Hg content. According to the molar ratio and correlation results, we assume that Se binding is not the primary detoxification pathway for Cd and Hg in brown bears.

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Section: Relations Between Selenium Cadmium and Mercurysupporting

confidence: 65%

“…[5,10] One such mechanism is the in vivo formation of a non-toxic complex with Se and the redistribution of Cd and Hg. It is the most frequently proposed mechanism in both studies on experimental animals and environmental monitoring studies.…”

Section: Introductionmentioning

confidence: 99%

Selenium in brown bears (Ursus arctos) from Croatia: Relation to cadmium and mercury

Lazarus

Sekovanić

Reljić

et al. 2014

Journal of Environmental Science and Health, Part A

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“…[E] 77.8 ± 31.7 2) 125.9 ± 49.7 2) 2.2 ± 1. There was no significant difference between CdCl 2 + MF low group and CdCl 2 + MF middle group (P more than 0.05).…”

Section: Step-through Testmentioning

confidence: 99%

“…[1]. Its exposure is inevitable and may produce toxic effects in many organs and organ systems through binding to biological structures, accumulation in internal organs or induction of free radical production [2]. Therefore, how to clear the Cd accumulation in the body is an urgent and important mission.…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of maifanite against cadmium-induced oxidative stress to rats hippocampus by regulating the balance and metabolism of metals

Liao¹,

Jiang²,

Huang³

et al. 2013

Health

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In this paper, the author reported the effect of maifanite on the learning and memory of rats suffering Cd poisoning by step-down and stepthrough test, analyzed the content of MDA, MT, SOD, and GSH-Px in the hippocampus of rats respectively, and assayed the content of Fe, Cu, Zn, Mn, Se, and Cd in the hippocampus of rats. In the step-down test, it is found that maifanite can reduce the number of electric shock, prolong step-down latency, and cut down error times when rats are exposed to Cd 24 h. In the stepthrough test, maifanite can obviously prolong the latency of entering the dark cabin of rats suffering Cd poisoning. The exogenous Cd can lead to the decrease of SOD and GSH-Px activity and the increase of MDA and MT content. The alternation of maifanite and Cd by the gavage can significantly increase the SOD and GSH-Px activity as well as MT content, while lessening the MDA content. The accumulation of exogenous Cd in hippocampus causes the increase of Zn, Fe, Mn, and Cd content, and the decrease of Cu and Se content. The intake of maifanite can regulate the imbalance of metals content and make its content near to the of level control group. The research shows that maifanite can improve the ability of learning and memory of rats suffering Cd poisoning, increase MT formation and lower hyperoxidative damage. Maifanite has the function of balancing the content of trace elements in rats suffering Cd poisoning, and meanwhile can alleviate the toxicity of Cd effectively.

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Influence of cadmium on metallothionein expression and products of lipid peroxidation in the organs of hares (Lepus europaeus Pallas)

Linšak

Špirić

et al. 2013

J of Applied Toxicology

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Cadmium occurs naturally in the environment and as an anthropogenic pollutant. Exposure to low concentrations of cadmium is inevitable and may produce toxic effects. Another important aspect of cadmium toxicity is its interaction, often antagonistic, with essential elements such as selenium. The aim of this study was to highlight the risks of long-term exposure to low cadmium concentrations, using a scientific and chemical approach and hares (Lepus europaeus Pallas) as model organisms in a field study. Two study areas were monitored. Levels of cadmium and selenium were quantified in the organs of hares, the expression of metallothioneins I + II and the products of lipid peroxidation were determined. The median cadmium concentrations (wet weight) in the muscle, liver, kidney and brain of hares from an exposed group ranged from 0.033 to 0.037, 0.763 to 1.054, 3.090 to 16.594 and 0.016 to 0.087 µg g(-1), respectively; whereas, the median selenium concentrations (wet weight) ranged from 0.100 to 0.108, 0.153 to 0.332, 0.677 to 0.701 and 0.078 to 0.116 µg g(-1), respectively. Expression of the metallothioneins I + II proteins was observed in tissues. Lipid peroxidation (LPO) levels, measured as malondialdehyde (MDA) equivalents, increased with the cadmium concentration. Further research on long-term exposure to low concentrations of cadmium in the environment is needed.

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Cadmium and Selenium Interaction in Mammals

Cited by 15 publications

References 119 publications

Selenium in brown bears (Ursus arctos) from Croatia: Relation to cadmium and mercury

Selenium in brown bears (Ursus arctos) from Croatia: Relation to cadmium and mercury

Protective effect of maifanite against cadmium-induced oxidative stress to rats hippocampus by regulating the balance and metabolism of metals

Influence of cadmium on metallothionein expression and products of lipid peroxidation in the organs of hares (Lepus europaeus Pallas)

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