Cadmium, chromium, lead, manganese and nickel concentrations in blood of women in non-polluted areas in Japan, as determined by inductively coupled plasma-sector field-mass spectrometry

Ikeda, Masayuki; Ohashi, Fumiko; Fukui, Yoshinari; Sakuragi, Sonoko; Moriguchi, Jiro

doi:10.1007/s00420-010-0542-2

Cited by 49 publications

(34 citation statements)

References 43 publications

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“…Application of the nation-wide GM for Cd-B of 1.23 µg/ L 14) to the above-cited equation for Cd-D gave 16.5 µg/day, whereas the nation-wide GM for Cd-U cr , 1.26 µg/g cr 13) , gave 11.5 µg/day when applied to the second equation. Both estimates agree with each other in the sense that both suggest further reduction in Cd-D in recent years.…”

Section: Discussionmentioning

confidence: 92%

“…Cd in the acid digests of the food duplicates, rice (Cd-R), peripheral blood (Cd-B) and urine samples (the second morning urine samples; Cd-U) were measured by the graphite furnace atomic absorption spectrometry (GF-AAS) 12,13) or inductively coupled plasma mass spectrometry (ICP-MS) 14) ; compatibility of the two methods was previously confirmed 14) .…”

Section: Methodsmentioning

confidence: 98%

“…Dietary Cd intake (Cd-D) was determined by the 24-hour food duplicate collection 11) followed by homogenization, acid digestion and instrumental analyses for Cd [12][13][14][15] . Cd in the acid digests of the food duplicates, rice (Cd-R), peripheral blood (Cd-B) and urine samples (the second morning urine samples; Cd-U) were measured by the graphite furnace atomic absorption spectrometry (GF-AAS) 12,13) or inductively coupled plasma mass spectrometry (ICP-MS) 14) ; compatibility of the two methods was previously confirmed 14) .…”

Section: Methodsmentioning

confidence: 99%

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Cadmium Exposure in General Populations in Japan: a Review

et al. 2015

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Cadmium (Cd) intake via diet (Cd-D) has been a long-standing focus of administrative as well as public concern in Japan after the endemic of Itai-itai disease (chronic cadmium poisoning). The aim of this report was to review cadmium exposure in Japan by introducing publications from our study group and related articles. Literature survey disclosed that Cd-D was high (up to 100 µg/day) in 1960s even in non-polluted areas. Such high Cd-D levels were followed by gradual decreases in 1970s-1980s to current level of well below 20 µg/day. Once, a very high Cd-D (600 µg/day) was reported for a Cd-polluted area. Replacement of Cd-polluted rice paddy soil with clean soil resulted in substantial reduction in riceassociated Cd-D. In large-scale surveys in 10 prefectures all over Japan conducted early in 2000s, the geometric mean (GM) of Cd-U cr (Cd in urine as corrected for creatinine concentration) was 1.26 µg/g cr, but was higher in one north-west sea coast prefecture in Honshu Island (>3 µg/g cr). Supplemental survey in 6 neighboring prefectures on the sea coast disclosed that Cd-U cr in some prefectures were higher as compared with the national average. It was reported that Cd in brown rice was also high. However no clear-cut indication was detected to suggest renal tubular dysfunctions. Surveys in major cities in East and South-East Asia in 1980s-1990s made it clear that Cd-D was substantially lower there than in Japanese cities; Cd exposure of general populations was almost exclusively from foods. Statistical analysis revealed that tubular dysfunction markers increased sharply when Cd-U cr exceeded 10-12 µg/g cr. The Cd-U cr level of 11 µg/g cr corresponded to Cd-D level of 59 µg/day. This level was in agreement with the tolerable weekly intake of 7 µg/kg body weight/week, the value recommended by the Food Safety Commission of Japan.

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Section: Discussionmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

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Cadmium Exposure in General Populations in Japan: a Review

et al. 2015

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“…In case of ICP-MS analysis, an aliquot (100 μ l) of each blood sample was digested in presence of 500 μ l of 68% (about 14.8N) nitric acid in a closed vessel by the microwave method, and the digest was taken up in 5 ml of ultra-pure water. The solution was introduced to an ICP-MS system (Thermo Scientific ELEMENT2 High Performance High Resolution ICP-MS, Thermo Fisher Scientific Inc, Bremen, Germany) as previously detailed 6) . The standard addition method was employed for quantification in both analytical methods.…”

Section: Blood Analyses For CDmentioning

confidence: 99%

“…In recent years, increasing attention has been paid to inductivelycoupled plasma-mass spectrometry (ICP-MS) as a method for metal analysis with the instrument and material limits of determination substantially lower than that for GFAAS 5,6) . Nevertheless, studies on the compatibility between the two methods are few in literature; only two reports 7,8) are available with conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of GFAAS and ICP-MS for Analyses of Cadmium in Blood

et al. 2011

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Cadmium in blood (Cd-B) is an important indicator, next to Cd in urine, in biological monitoring of exposure to Cd. The present study was initiated to examine compatibility in results of analysis for Cd-B between graphite furnace atomic absorption spectrophotometry (GFAAS) and inductively-coupled plasma mass-spectrometry (ICP-MS). For this purpose, 1,159 blood samples were collected from adult women (with no occupational exposure to Cd) in eight prefectures nation-widely in Japan. The samples were analyzed by the two methods; geometric mean (the maximum) concentrations were 1.22 (6.90) μg/l by ICP-MS, and 1.47 (7.40) μg/l by GFAAS. Statistical analyses showed that there was a close correlation between the results by the two methods. The regression line (with ICP-MS and GFAAS results as an independent variable and a dependent variable, respectively) had a slope close to one and an intercept next to zero to suggest that ICP-MS gave values compatible with that of GFAAS. Further analysis with the ratio of Cd-B by GFAAS over that by ICP-MS revealed that the two results were close to each other, and that the agreement was even closer when Cd-B was >2 μg/l. Thus, the two methods can be employed inter-convertibly when Cd-B is relatively high, e.g. >2 μg/l. Care may need to be practiced, however, for possible 'between methods' difference when Cd-B is low, e.g., ≤2 μg/l.

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Nickel, Ni

Binkowski¹

2019

Mammals and Birds as Bioindicators of Trace Element Contaminations in Terrestrial Environments

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Cadmium, chromium, lead, manganese and nickel concentrations in blood of women in non-polluted areas in Japan, as determined by inductively coupled plasma-sector field-mass spectrometry

Cited by 49 publications

References 43 publications

Cadmium Exposure in General Populations in Japan: a Review

Cadmium Exposure in General Populations in Japan: a Review

Comparative Evaluation of GFAAS and ICP-MS for Analyses of Cadmium in Blood

Nickel, Ni

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