Cadmium concentration in biological media of breast cancer patients

Strumylaitė, Loreta; Boguševičius, Algirdas; Abdrachmanovas, Olegas; Baranauskienė, Dalė; Kregždytė, Rima; Pranys, Darius; Poškienė, Lina

doi:10.1007/s10549-010-1007-8

Cited by 81 publications

(63 citation statements)

References 27 publications

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“…It has been acknowledged that the role of environmental factors might be more important than the genetics, which are responsible for 80 % of cancer causes (Parsa 2012). About half of breast cancer cases can be explained by known risk factors including the reproductive life, inheritance, and socioeconomic status; however, the rest of the cases could have an environmental etiology (Strumylaite et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Cadmium exposure and the risk of breast cancer in Chaoshan population of southeast China

Lin

Huang

Zhang

et al. 2015

Environ Sci Pollut Res

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Recently, there is increasing evidence indicating a link between cadmium exposure and human breast cancer. This study was aimed to explore the relationship between blood cadmium burden and the risk of breast cancer in Chaoshan women with no occupational exposure. Blood cadmium levels (BCLs) were determined in whole blood of 186 breast cancer cases and 139 controls. Basic clinical data and information of age, occupation, blood types, family cancer history, and disease history, as well as other demographic characteristics were collected from medical records. BCLs were detected by graphite-furnace atomizer absorption spectrophotometer (GFAAS). BCLs and proportions of BCLs over 3 μg/L between cases and controls were compared. The relationships between BCLs and breast cancer were explored by comparing BCL differences between/among different characteristics of investigated factors. In addition, BCLs within cases were also compared in relation to the disease clinical stages, tumor-node-metastasis (TNM) stages, and estrogen receptor (ER), progesterone receptor (PR), and Cerb-B2 expressions. The breast cancer patients had a higher median concentration of blood cadmium (2.28, interquartile range 1.57-3.15 μg/L) than the controls (1.77, 1.34-2.57 μg/L; P = 0.001). The proportion of BCLs over 3 μg/L was 2.35 times higher in the breast cancer cases than that of the controls after adjusting for age. Cadmium tends to accumulate in the human body with age and body mass index (BMI) but not associates with type of job, family history, disease history, and other investigated characters. With the increase of clinical stages and T and M stages, the BCLs in the breast cancer cases also increased. BCLs were positively associated with Cerb-B2 expression (r = 0.152, P = 0.038) but not significantly associated with ER and PR expressions. The data obtained show that cadmium concentration is significantly higher in blood of breast cancer patients in comparison to healthy controls. Cadmium seems to be a risk factor of breast cancer, and high cadmium exposure was observed in advanced stages of this disease, which indicates that it may promote the development of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Cadmium exposure and the risk of breast cancer in Chaoshan population of southeast China

Lin

Huang

Zhang

et al. 2015

Environ Sci Pollut Res

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“…There were 13 studies including 978 exposed cases and 1279 controls ( Figure 1) (Antila et al, 1996;Ionescu et al, 2006;McElroy et al, 2006;Wu et al, 2006;Pasha et al, 2008;Strumylaite et al, 2008;Gallagher et al, 2010;Benderli Cihan et al, 2011;Saleh et al, 2011;Strumylaite et al, 2011;Kotsopoulos et al, 2012;Nagata et al, 2013). The characterization of all selected studies was summarized in Table 1.…”

Section: Meta-analysismentioning

confidence: 99%

Breast Cancer Frequency and Exposure to Cadmium: A Meta-Analysis and Systematic Review

Rahim

Jalali²,

Tangestani³

2013

Asian Pacific Journal of Cancer Prevention

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Background: In this meta-analysis we review evidence suggesting that exposure to cadmium is a cause of breast cancer. Materials and Methods: We conducted Medline/PubMed and Scopus searches using selected MeSH keywords to identify papers published from January 1, 1980 through January 1, 2013. Data were merged and summary mean differences were estimated using either a random-effects model or a fixed-effects model. Results: There were 13 studies including 978 exposed cases and 1,279 controls. There was no statistically significant difference in the frequencies of breast cancer between cadmium-exposed and control groups, and the summary estimate of mean difference was 0.71 (95%CI: 0.33-1.08). However, stratification showed that there were statistically significant differences in the frequencies of breast cancer between cadmium-exposed and control groups among Asian compared with Caucasian population, and the summary estimates of mean difference were 1.45 (95%CI: 0.62-2.28) vs. 0.25 (95%CI: -0.09-0.6), respectively. There was a difference in the frequencies of breast cancer between cadmium-exposed and control groups in peripheral venous blood sampling methods, and the summary estimate of mean difference was 1.41 (95%CI: 0.46-2.37). Conclusions: Data indicate that the frequencies of breast cancer might be an indicator of early genetic effects for cadmium-exposed populations. However, our meta-analysis was performed on population-based studies; meta-analysis based on individual data might provide more precise and reliable results. Therefore, it is necessary to construct an international database on genetic damage among populations exposed to cadmium that may contain all raw data of studies examining genetic toxicity.

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“…Just itai-itai disease is connected with damage of bones and is characterized by multiple fractures of the long bones in the skeleton (Wang et al 1994). Carcinogenicity of cadmium is widely discussed (Barrett 2009;Chen et al 2009;Strumylaite et al 2009Strumylaite et al , 2010Absalon and Slesak 2010;Gallagher et al 2010;Julin et al 2010;Talaat et al 2010). It has been proposed as a prostate and renal carcinogen, however, available data are still controversial (Kolonel 1976;Il'yasova and Schwartz 2005).…”

Section: Cadmium As An Important Contaminant Of Living Environmentmentioning

confidence: 99%

Cadmium Accumulation by Plants of Brassicaceae Family and Its Connection with Their Primary and Secondary Metabolism

Babula

Adam

Havel

et al. 2012

The Plant Family Brassicaceae

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The mustard family -Brassicaceae -is well known as family of plants, metallophytes, which are able to accumulate wide range of heavy metals and metalloids, especially zinc and cadmium, but also nickel, thallium, chromium and selenium. Ecological importance of this process consists partially in plants themselves to survive negative environmental conditions. There are two basic different strategies, how to survive these conditions -accumulation of heavy metals in plants tissues with different intensity in individual cell types, but also organs, which is partially given by chemical composition of cell walls, and ability to synthesize special defensive -detoxification compounds rich on thiol groupsglutathione and phytochelatins, which are able to bind heavy metals and transport them to the "secure" cell compartment -vacuole. The second principle is based on ability to exclude heavy metals. Role of secondary metabolites rich on sulphur in detoxification of heavy metals is still discussed with unclear conclusions. Members of Brassicaceae family, especially genera Thlaspi and Brassica, are well-known hyperaccumulators of heavy metals with possible utilization in phytoremediation technologies. In this review chapter, mechanisms of cadmium uptake and transport and its deposition in various plant cells and tissues are discussed with respect with

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Cadmium concentration in biological media of breast cancer patients

Cited by 81 publications

References 27 publications

Cadmium exposure and the risk of breast cancer in Chaoshan population of southeast China

Cadmium exposure and the risk of breast cancer in Chaoshan population of southeast China

Breast Cancer Frequency and Exposure to Cadmium: A Meta-Analysis and Systematic Review

Cadmium Accumulation by Plants of Brassicaceae Family and Its Connection with Their Primary and Secondary Metabolism

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