Cadmium Exposure Is Associated With Elevated Blood C-Reactive Protein and Fibrinogen in the U. S. Population: The Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994)

Lin, Yu‐Sheng; Rathod, Dhruv; Ho, Wen‐Chao; Caffrey, James L.

doi:10.1016/j.annepidem.2009.02.005

Cited by 51 publications

(26 citation statements)

References 28 publications

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“…The presented correlation between BCd and fibrinogen level confirms the study of Lin et al [37], which demonstrated a similar correlation between Cd concentration in urine and fibrinogen plasma levels in cohort research on humans. It has been suggested that the increase in the plasma fibrinogen level may result from the effect of the associated cadmium exposure on the vascular endothelial cells, which are the initial site of hepatic injury especially in smoking female patients, which was confirmed by studies performed on animals [38].…”

Section: Discussionsupporting

confidence: 79%

The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

Nasiadek¹,

Kilanowicz²,

Daragó³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Objectives: Cadmium (Cd) is a persistent and widespread environmental pollutant, which may constitute a potential risk factor for hormone-dependent tumors such as endometrial cancer. The vascular endothelium is an important target of cadmium toxicity, which may interfere with the coagulation cascade and fibrinolytic system. The aim of this research was to investigate whether in female patients with uterine endometrial cancer or myoma in comparison to healthy women, the concentration of cadmium in blood affects the process of coagulation and fibrinolysis. Materials and Methods: The study group comprised 91 women: 35 healthy (A-control), 39 with uterine myoma (B) and 17 with endometrial cancer (C), in which blood cadmium concentrations (BCd), coagulation and selected fibrinolysis parameters in plasma were assayed. Results: In the women with myoma and especially in those with endometrial cancer disturbances in coagulation and fibrinolysis were detected when compared to the healthy women. In the group of women with endometrial cancer significant changes in prothrombin index, levels of fibrinogen, fibrin D-dimer and t-PA were observed. Whereas, in the patients with myoma significant changes in prothrombin time, index of vWillebrand Factor and fibrin D-dimer level were noted. Mean BCd concentrations in subsequent groups were as follows: B -0.91±0.81; C -0.78±0.45 μg Cd/l and did not differ significantly in comparison with the control group (0.86±0.35 μg Cd/l). However, in each study group smokers had approximately twice as high BCd as non-smokers. Studies also showed significant associations between BCd and fibrinogen level and thrombin time among the women with myoma and endometrial cancer, as well as in healthy women. Moreover, thrombin time significantly correlated with fibrinogen level in the women studied. Conclusions: In the patients with myoma and especially in these with endometrial cancer disturbances in coagulation and fibrinolysis parameters leading to hypercoagulability were detected. Exposure to cadmium can be one of the factors inducing these changes.

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Section: Discussionsupporting

confidence: 79%

The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

Nasiadek¹,

Kilanowicz²,

Daragó³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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“…tes and hypercholesterolemia. In another study of NHANES III (1988-1994 participants, aged 40-79 years, high serum levels of CRP and fibrinogens were associated with urinary Cd levels in a dose-dependent manner (Lin et al 2009). In NHANES 1999-2004, blood Cd levels among men ≥ 40 years of age rose with increasing serum ALP levels (Cheung et al 2009).…”

Section: Cadmium -Mechanisms Of Toxicitymentioning

confidence: 99%

“…In NHANES 1999-2004, blood Cd levels among men ≥ 40 years of age rose with increasing serum ALP levels (Cheung et al 2009). Three separate analyses of the U.S. population data (Lee et al 2006;Cheung et al 2009;Lin et al 2009) have implicate Cd exposure as a risk factor in subclinical liver inflammation.…”

Section: Cadmium -Mechanisms Of Toxicitymentioning

confidence: 99%

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Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Satarug

Vesey

Gobé

2017

Tohoku J. Exp. Med.

104

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“…High-sensitivity C-reactive protein (hsCRP), a reliable and cost-effective marker of systemic inflammation, is now used to evaluate the effects of work-related risk factors, including job stress and toxic chemicals 1,2) . In prospective studies, higher circulating levels of hsCRP have been associated with an increased risk of future cardiovascular diseases, such as coronary heart disease, stroke and myocardial infarction 3,4) .…”

mentioning

confidence: 99%

Seasonal and Inter-day Variation in Serum High-sensitivity C-reactive Protein in Japanese Male Workers: A Longitudinal Study

et al. 2012

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Although seasonal variation in high-sensitivity C-reactive protein (hsCRP) has been studied cross-sectionally and longitudinally, the results to date have been mixed. Here, to test seasonal variation in this compound with regard to within-subject, inter-day variation, we conducted a longitudinal follow-up study with repeated measurements in Japanese workers with low hsCRP. Blood samples were obtained from four male indoor daytime workers, who were aged 32-57 and commuted to offices in Kawasaki City, on six days within 2-wk windows in February and October, 2008. Serum hsCRP was measured using ultrasensitive latex-enhanced immunonephelometry. Among the subjects with detectable levels of hsCRP, individual median serum hsCRP levels were 38-74% higher in October than in February (p=0.03). This study identified the presence of a seasonal variation in the serum hsCRP level of Japanese workers with low hsCRP levels.

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Cadmium Exposure Is Associated With Elevated Blood C-Reactive Protein and Fibrinogen in the U. S. Population: The Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994)

Cited by 51 publications

References 28 publications

The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

Seasonal and Inter-day Variation in Serum High-sensitivity C-reactive Protein in Japanese Male Workers: A Longitudinal Study

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