Cadmium in urothelial carcinoma of the bladder

Gołąbek, Tomasz; Darewicz, Barbara; Kudelski, Jacek; Socha, Katarzyna; Markiewicz‐Żukowska, Renata; Chłosta, Piotr; Okoń, Krzysztof; Borawska, Maria H.

doi:10.5114/pjp.2014.42670

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…Other studies on the carcinogenic mechanisms of Cr, Ni and Pb in the bladder are scant. Several clinical studies have attempted to quantify the levels of heavy metals in tumoral lesions and the adjacent normal parts of various organs in the urinary system; however, the results were controversial …”

Section: Discussionmentioning

confidence: 99%

Association between levels of urinary heavy metals and increased risk of urothelial carcinoma

Chang

Liu

et al. 2015

Int J of Urology

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Objectives: To evaluate possible sources of exposure to heavy metals in the general population, and to determine the association between urinary heavy metals and urothelial carcinoma risk. Methods: We recruited 205 patients with urothelial carcinoma and 406 control participants for a case-control study between June 2011 and December 2013. The control participants were frequency-matched with cases according to sex and age. We measured the urinary levels of arsenic, cadmium, chromium, nickel and lead by using inductively coupled plasma mass spectrometry. We collected environmental exposurerelated information through questionnaires. Multivariate logistic regression and 95% confidence intervals were applied to estimate the urothelial carcinoma risk and potential effects of urothelial carcinoma-related risk factors on the levels of urinary heavy metals. Results: Patients with urothelial carcinoma showed higher urinary levels of arsenic, cadmium, chromium, nickel and lead than the controls. After considering other potential risk factors, a significantly increased risk for urothelial carcinoma was observed in patients with increased urinary levels of cadmium, chromium, nickel and lead. Smokers showed a high urinary cadmium level. In addition to cadmium, a high urinary lead level was associated with cumulative cigarette smoking and herbal medicine use. Conclusion: Environmental factors might contribute to higher urinary levels of heavy metals and ultimately result in urothelial carcinoma carcinogenesis. These findings can promote proper environmental surveillance of exposure to heavy metals in the general population.

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Section: Discussionmentioning

confidence: 99%

Association between levels of urinary heavy metals and increased risk of urothelial carcinoma

Chang

Liu

et al. 2015

Int J of Urology

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“…Golabek et al 41 Gallbladder activity, and the maintenance of vitamin E levels, although it had no effect on OS markers. 32 Besides, oral Zn sulfate supplements have been reported to improve the activity of Cu/Zn SOD enzyme in head and neck cancer (HNC) patients during radiotherapy.…”

Section: CDmentioning

confidence: 99%

The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

Tehrani

Hosseini

Yousefi

et al. 2018

J of Cellular Biochemistry

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DNA damage response (DDR) is a regulatory system responsible for maintaining genome integrity and stability, which can sense and transduce DNA damage signals. The severity of damage appears to determine DDRs, which can include damage repair, cell‐cycle arrest, and apoptosis. Furthermore, defective components in DNA damage and repair machinery are an underlying cause for the development and progression of various types of cancers. Increasing evidence indicates that there is an association between trace elements and DDR/repair mechanisms. In fact, trace elements seem to affect mediators of DDR. Besides, it has been revealed that oxidative stress (OS) and trace elements are associated with cancer development. In this review, we discuss the role of some critical trace elements in the risk of cancer. In addition, we provide a brief introduction on DDR and OS in cancer. Finally, we will further review the interactions between some important trace elements including selenium, zinc, chromium, cadmium, and arsenic, and DDR, and OS in cancer.

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“…Bladder cancer is very common malignancy in the world, and it is estimated that about 550,000 new cases are diagnosed yearly [6][7][8]. The type of cancer is described by its grade under microscope.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma

Kudelski

Młynarczyk

Gudowska-Sawczuk

et al. 2021

JCM

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Human urinary bladder cancer is a huge worldwide oncological problem causing many deaths every year. The degradation of extracellular matrix (ECM) induced by molecules such as matrix metalloproteinases (MMPs) is one of the main factors influencing the process of metastasis origination. The MMP expression is tied to tumor aggressiveness, stage, and patient prognosis. The cleavage of constituent proteins is initiated and prolonged by matrix metalloproteinases, such as MMP-3 and MMP-10. The aim of this study was to evaluate the expression and activity of both MMPs in human urinary bladder cancer occurring at various stages of the disease. Tissue samples from patients with urinary bladder cancer were analyzed. Samples were collected from patients with a low- and high-grade cancer. Control tissue was collected from the site opposite to the tumor. DNA content, MMPs content, and activity of MMP-3 and MMP-10 were measured using ELISA and Western blot techniques. MMP-3 and MMP-10 occur in high molecular complexes in human urinary bladder in healthy and cancerous tissues. Particularly, in high-grade tumors, the content of MMP-10 prevails over MMP-3. The actual and specific activities vary in both grades of urinary bladder cancer; however, the highest activity for MMP-3 and MMP-10 was found in low-grade tissues. In conclusion, MMP-10 had a higher content, but a lower activity in all investigated tissues compared to MMP-3. Generally, obtained results demonstrated a contrary participation of MMP-3 and MMP-10 in ECM remodeling what may be crucial in the pathogenesis of human urinary bladder carcinoma.

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Cadmium in urothelial carcinoma of the bladder

Cited by 7 publications

References 25 publications

Association between levels of urinary heavy metals and increased risk of urothelial carcinoma

Association between levels of urinary heavy metals and increased risk of urothelial carcinoma

The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma

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