Cadmium-induced nephropathy in the development of high blood pressure

Satarug, Soisungwan; Nishijo, Muneko; Ujjin, Pailin; Vanavanitkun, Yuvaree; Moore, Michael R.

doi:10.1016/j.toxlet.2005.01.004

Cited by 118 publications

(85 citation statements)

References 43 publications

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“…A recent report of NHANES showed a lower odds ratio for hypertension in the highest urinary Cd quartile compared with the lowest ( . In contrast to these negative findings, Satarug et al (2005) reported a positive association between blood pressure and urinary Cd in a population sample of 200 subjects that also showed tubular dysfunction. The association between blood pressure and cardiovascular risk is continuous without a threshold .…”

Section: Blood Pressure and Effects On Arteriesmentioning

confidence: 77%

Cadmium exposure in the population: from health risks to strategies of prevention

et al. 2010

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We focus on the recent evidence that elucidates our understanding about the effects of cadmium (Cd) on human health and their prevention. Recently, there has been substantial progress in the exploration of the shape of the Cd concentrationresponse function on osteoporosis and mortality. Environmental exposure to Cd increases total mortality in a continuous fashion without evidence of a threshold, independently of kidney function and other classical factors associated with mortality including age, gender, smoking and social economic status. Pooled hazard rates of two recent environmental population based cohort studies revealed that for each doubling of urinary Cd concentration, the relative risk for mortality increases with 17% (95% CI 4.2-33.1%; P \ 0.0001). Tubular kidney damage starts at urinary Cd concentrations ranging between 0.5 and 2 lg urinary Cd/g creatinine, and recent studies focusing on bone effects show increased risk of osteoporosis even at urinary Cd below 1 lg Cd/g creatinine. The non-smoking adult population has urinary Cd concentrations close to or higher than 0.5 lg Cd/g creatinine. To diminish the transfer of Cd from soil to plants for human consumption, the bioavailability of soil Cd for the plants should be reduced (external bioavailability) by maintaining agricultural and garden soils pH close to neutral (pH-H 2 O of 7.5; pH-KCL of 6.5). Reducing the systemic bioavailability of intestinal Cd can be best achieved by preserving a balanced iron status. The latter might especially be relevant in groups with a lower intake of iron, such as vegetarians, and women in reproductive phase of life. In exposed populations, house dust loaded with Cd is an additional relevant exposure route. In view of the insidious etiology of health effects associated with low dose exposure to Cd and the current European Cd intake which is close to the tolerable weekly intake, one should not underestimate the importance of the recent epidemiological evidence on Cd toxicity as to its medical and public health implications.

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Section: Blood Pressure and Effects On Arteriesmentioning

confidence: 77%

Cadmium exposure in the population: from health risks to strategies of prevention

et al. 2010

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“…Some epidemiologic studies have found positive associations between body Cd levels and elevated blood pressure or hypertension [33][34][35][36]. It was reported in literature that both active and passive smoking [37] are associated with the development of several clinical disorders, that alters LDL (low-density lipoprotein) [38], reducing the endothelium-dependent relaxation induced by acetylcholine.…”

Section: Discussionmentioning

confidence: 99%

Estimation of toxic elements in the samples of different cigarettes and their impact on human health of Irish hypertensive consumers

Afridi

Kazi

Talpur

et al. 2013

Clinica Chimica Acta

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Background: Cigarette smoking interferes with the metal homeostasis of the human body, which plays a crucial role for maintaining the health. A significant flux of heavy metals, among other toxins, reaches the lungs through smoking. In the present study, the relationship between toxic element (TE) exposure via cigarette smoking and hypertension incidence in population living in Dublin, Ireland is investigated. Methods: The different brands of cigarette (filler tobacco, filter and ash) consumed by the studied population were analyzed for cadmium (Cd), nickel (Ni), and lead (Pb). The concentrations of TEs in biological samples and different components of cigarette were measured by inductively coupled plasma atomic emission spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked using certified reference materials. Results: The filler tobacco of different branded cigarettes contains Cd, Ni and Pb concentrations in the ranges of 1.73-2.02, 0.715-1.52 and 0378-1.16 pg/cigarette, respectively. The results of this study showed that the mean values of Cd, Ni and Pb were significantly higher in scalp hair and blood samples of hypertensive patients in relation to healthy controls, while the difference was significant in the case of smoker patients (p < 0.001). The levels of all the three TEs were 2-3 folds higher in scalp hair and blood samples of non-hypertensive smoker subjects as compared to nonsmoker controls. Conclusion: The high exposure of toxic metals as a result of cigarette smoking may be synergistic with risk factors associated with hypertension.

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“…The other mechanism of Cd-induced hypertension suggested by Satarug et al (2006) is that Cd deposited in human kidney leads to alterations in metal homeostasis and redox state, changes in gene expression profiles, and ultimately tubular injury. Increased risk of hypertension is found in humans with nephropathy caused by environmental Cd exposure (Satarug et al 2005). …”

Section: Cadmium-induced Cardiovascular Dysfunctionmentioning

confidence: 99%

“…The most commonly affected organ systems are the kidney, lung, bone and skeletal, cardiovascular, and nervous systems (Jaishankar et al 2014). Observational studies indicate that chronic Cd exposure is associated with an increased risk of cardiovascular disease, including hypertension, atherosclerosis, nephropathy, and diabetes (Puri 1999;Satarug et al 2005;Eum et al 2008;Prozialeck et al 2008;Messner and Bernhard 2010;Alissa and Ferns 2011;ATSDR 2012;Satarug and Moore 2012).…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

Kukongviriyapan

Apaijit

Kukongviriyapan

2016

Tohoku J. Exp. Med.

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Cadmium (Cd) is a non-essential heavy metal with high toxicity potential. Humans are exposed to Cd present in diet, polluted air, and cigarette smoke. Cd exposure has been associated with increased risk of chronic diseases, including hypertension, atherosclerosis, diabetes, and nephropathy, all of which could be attributable to dysfunctional endothelial and smooth muscle cells. Cd toxicity is correlated with increased reactive oxygen formation and depletion of antioxidants, resulting in an oxidative stress. Chelation of Cd has proved useful in the removal of the Cd burden. However, several chelating agents cause side effects in clinical usage. Recent studies have shown that the antioxidant compounds curcumin and tetrahydrocurcumin can alleviate vascular dysfunction and high blood pressure caused by Cd toxicity. In chronic Cd exposure, these antioxidants protect vascular endothelium by increasing nitric oxide (NO•) bioavailability and improving vascular function. Antioxidant activity against Cd intoxication results directly and/or indirectly through free radical scavenging, metal chelation, enhanced expression of the antioxidant defense system, regulation of inflammatory enzymes, increase in NO• bioavailability, and reduction of gastrointestinal absorption and tissue Cd accumulation. This review summarizes current knowledge of Cd-induced oxidative stress and cardiovascular dysfunction and a possible protective effect conferred by the antioxidants curcumin and tetrahydrocurcumin.

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Cadmium-induced nephropathy in the development of high blood pressure

Cited by 118 publications

References 43 publications

Cadmium exposure in the population: from health risks to strategies of prevention

Cadmium exposure in the population: from health risks to strategies of prevention

Estimation of toxic elements in the samples of different cigarettes and their impact on human health of Irish hypertensive consumers

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

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