Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand

Honda, Ryumon; Swaddiwudhipong, Witaya; Nishijo, Muneko; Mahasakpan, Pranee; Teeyakasem, Wimonrat; Ruangyuttikarn, Werawan; Satarug, Soisungwan; Padungtod, Chantana; Nakagawa, Hideaki

doi:10.1016/j.toxlet.2010.04.023

Cited by 94 publications

(56 citation statements)

References 33 publications

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“…This would restrict the capacity of the seedlings to absorb nutrient and moisture from soil which may hamper their further growth [40]. The effect of the heavy metal on dry weight of various plant parts is given in Table- [42][43]. The dry mass of embryonic axis increases with seedling age and is associated with decline in cotyledonary dry mass [44].The effect of the heavy metals on pigments is given in Table- (Table-4 (Table-6).…”

Section: Resultsmentioning

confidence: 99%

Untitled

2018

RJLBPCS

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ABSTRACT:The heavy metals, Cd 2+ , Ni 2+ , and Pb 2+ quantitative accumulation occurred in the order radical>plumule>leaves. Seed germination percentage was affected only at relatively higher concentrations.At the lower concentration of the heavy metals 0.1 mM for Cd 2+ , 1 mM for Ni 2+ and Pb 2+ there was only delay in the germination. Early seedling growth was however, quite sensitivity even at low concentrations.As compared to plumule, the growth of the radical was affected to a relatively greater extent, by all the three heavy metals. There was a pronounced effect on elongation of radical. The fresh and dry weights of different plant organs were considerably reduced in heavy metal treated plants and this decrease, increase with concentration of heavy metal applied. The dry mass of embryonic axis increases with the seedling age and is associated with decline in cotyledonary dry mass. The embryonic axis dry weight as % of total dry weight decrease in case of heavy metals. The heavy metals resulted in a decrease in the nitrogen (%) of the various plant parts as compared to control. The percentage of nitrogen in radical and plumule decreased with the increase in concentration of the heavy metals. However in case of cotyledons the percentage of nitrogen increased with increase in concentration of the heavy metals. The protein content of plumule and radical increased with the heavy metal concentration, the reverse was observed in case of cotyledons. In the present investigation the amount of the total chlorophyll and carotenoids was reduced by the heavy metals and the reduction in the total chlorophyll and carotenoids was concentration dependent.

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Section: Resultsmentioning

confidence: 99%

Untitled

2018

RJLBPCS

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“…Toxic factors identified up to now include arsenic, cadmium and nephrotoxic agrochemicals (WHO, 2011). In some areas in China and Thailand, production of highly Cd polluted rice and renal dysfunctions among populations were reported (Nordberg et al, 1997;Jin et al, 2002;Honda et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Effect of cadmium on growth parameters and plant accumulation in different rice (Oryza sativa L.) varieties in Sri Lanka

Herath¹,

Bandara

Weerasinghe³

et al. 2015

Trop. Agric. Res.

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“…Impaired tubular reabsorption of glucose has been noted in high-dose exposure situations (Nishijo et al 2004;Honda et al 2010). Such increased urinary glucose excretion may be indicative of mitochondrial toxicity of Cd in proximal tubular cells, affecting oxidative phosphorylation and ATP output (Gobe and Crane, 2010).…”

Section: Impaired Glucose Reabsorptionmentioning

confidence: 99%

“…There are no therapeutically effective metal chelating agents for reducing Cd levels in kidneys. Cd-linked kidney damage presumably causes a reduction in tubular reabsorption of nutrients (glucose, amino acids, zinc, calcium), and low molecular weight proteins, notably β2-microglobulin (β2-MG), α1-microglobulin (α1-MG), and retinol binding protein (RBP) (Honda et al 2010;Wallin et al 2014). Consequently, elevated urinary levels of these solutes are often used to reflect tubular malfunction.…”

Section: Introductionmentioning

confidence: 99%