Cadmium ion-doped magnetic poly(styrene-acrylic acid) nanospheres for sensitive electrochemical immunoassay

Zhang, Bing; Cui, Yuling; Liu, Bingqian; Chen, Huafeng; Tang, Dianping

doi:10.1016/j.bios.2012.02.051

Cited by 15 publications

(3 citation statements)

References 24 publications

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“…The interaction of conjugated Ab’s led to the release of TB, and the released probe was electrochemically detected by CV. The strategy of “huge” molecular tags carrying several electrochemically active molecules is represented by cadmium ion-doped magnetic poly(styrene–acrylic acid) nanospheres and carbon nanospheres with protein cage NPs …”

Section: Nanoparticles For Immunosensingmentioning

confidence: 99%

“…The strategy of "huge" molecular tags carrying several electrochemically active molecules is represented by cadmium ion-doped magnetic poly(styrene−acrylic acid) nanospheres and carbon nanospheres with protein cage NPs. 106 Enzyme mimic tags are very attractive due to their high stability and resistance against harsh conditions. There are many applications of magnetic particles serving as enzyme mimic tags.…”

Section: Magnetic Particles Asmentioning

confidence: 99%

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Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges

et al. 2017

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We review the progress achieved during the recent five years in immunochemical biosensors (immunosensors) combined with nanoparticles for enhanced sensitivity. The initial part introduces antibodies as classic recognition elements. The optical sensing part describes fluorescent, luminescent, and surface plasmon resonance systems. Amperometry, voltammetry, and impedance spectroscopy represent electrochemical transducer methods; electrochemiluminescence with photoelectric conversion constitutes a widely utilized combined method. The transducing options function together with suitable nanoparticles: metallic and metal oxides, including magnetic ones, carbon-based nanotubes, graphene variants, luminescent carbon dots, nanocrystals as quantum dots, and photon up-converting particles. These sources merged together provide extreme variability of existing nanoimmunosensing options. Finally, applications in clinical analysis (markers, tumor cells, and pharmaceuticals) and in the detection of pathogenic microorganisms, toxic agents, and pesticides in the environmental field and food products are summarized.

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Section: Nanoparticles For Immunosensingmentioning

confidence: 99%

Section: Magnetic Particles Asmentioning

confidence: 99%

Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges

et al. 2017

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“…In recent years, the immunological detection method of heavy metals has been demonstrated to be more suitable for large-scale sample detection, such as in a Cd detection kit, due to its advantages of rapid detection speed, low cost and a good application prospect [32,33]. Over the past decade or so, immunoassays have been widely applied in various methods to detect of various heavy metals [34], such as immunochromatographic kits [35], fluorescent-labeled immunoassays [36][37][38] and nanoparticle-labeled immunoassays [39,40]. However, due to the complex sample preparation process, the above detection methods are often limited to the research of detection methods and the application of water sample detection [41], which has influenced the development of the rapid detection of heavy metals in food packaging materials.…”

Section: Introductionmentioning

confidence: 99%

Establishment of an Indirect Competitive Enzyme-Linked Immunosorbent Method for the Detection of Heavy Metal Cadmium in Food Packaging Materials

Chen

et al. 2021

Foods

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Heavy metals in food packaging materials have been indicated to release into the environment at slow rates. Heavy metal contamination, especially that of cadmium (Cd), is widely acknowledged as a global environment threat that leads to continuous growing pollution levels in the environment. Traditionally, the detection of the concentration of Cd relies on expensive precision instruments, such as inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES). In this study, an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) based on a specific monoclonal antibody was proposed to rapidly detect Cd. The half-inhibitory concentration and detection sensitivity of the anti-cadmium monoclonal antibody of the ic-ELISA were 5.53 ng mL−1 and 0.35 ng mL−1, respectively. The anti-Cd monoclonal antibody possessed high specificity while diagnosising other heavy metal ions, including Al (III), Ca (II), Cu (II), Fe (III), Hg (II), Mg (II), Mn (II), Pb (II), Zn (II), Cr (III) and Ni (II). The average recovery rates of Cd ranged from 89.03–95.81% in the spiked samples of packing materials, with intra- and inter-board variation coefficients of 7.20% and 6.74%, respectively. The ic-ELISA for Cd detection was applied on 72 food packaging samples that consisted of three material categories—ceramic, glass and paper. Comparison of the detection results with ICP-AES verified the accuracy of the ic-ELISA. The correlation coefficient between the ic-ELISA and the ICP-AES methods was 0.9634, demonstrating that the proposed ic-ELISA approach could be a useful and effective tool for the rapid detection of Cd in food packaging materials.

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A silver(I) doped bud-like DNA nanostructure as a dual-functional nanolabel for voltammetric discrimination of methylated from unmethylated genes

et al. 2018

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Cadmium ion-doped magnetic poly(styrene-acrylic acid) nanospheres for sensitive electrochemical immunoassay

Cited by 15 publications

References 24 publications

Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges

Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges

Establishment of an Indirect Competitive Enzyme-Linked Immunosorbent Method for the Detection of Heavy Metal Cadmium in Food Packaging Materials

A silver(I) doped bud-like DNA nanostructure as a dual-functional nanolabel for voltammetric discrimination of methylated from unmethylated genes

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