Cadmium, one of the villains behind the curtain: has exposure to cadmium helped to pull the strings of seropositive rheumatoid arthritis pathogenesis all along?

Hutchinson, David

doi:10.1111/1756-185x.12673

Cited by 28 publications

(29 citation statements)

References 43 publications

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“…Background: Smoking has emerged as a consistent risk factor for ACPA positive RA, although the specific constituents of cigarette smoke that induce citrullination are unknown. It has been hypothesised that cadmium triggers RA as its inhalation links various well established risk factors for RA such as smoking (the most important environmental source of cadmium) and numerous working class occupations [1]. Objectives: To determine whether the cadmium-derived materials induce intracellular citrullination.…”

Section: Methodsmentioning

confidence: 99%

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AB0110 Evaluation of the effect of chuantengtongbi decoction on DBA / 1 MICE cia model

Wang

Shen

et al. 2017

Abstracts Accepted for Publication

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BackgroundDBA/1 mouse (H2q type) CIA model as a mature model of rheumatoid arthritis is widely used in pharmacology and pharmacodynamics research[1]. Chinese medicine treatment of rheumatoid arthritis has accumulated rich experience. The study of Tripterygium glycosides is quite representative, and it has been widely used in the past 30 years. Some Clinical studies showed that tripterygium glycosides treatment of rheumatoid arthritis had good effect[2]. ChuanTengTongBi decoction is also the effective prescription commonly used for the treatment of rheumatoid arthritis.ObjectivesTo investigate the pathological damage degree of DBA/1 mouse CIA model and the effects of different doses of ChuanTengTongBi decoction on the CIA model mice.MethodsThe mice were divided into normal group, model group, leflunomide group (3.11mg/kg/d), low-dose of ChuanTengTongBi group (0.44g/ml/d), medium-dose group (0.88g/ml/d) and high-dose group (1.76g/ml/d).ResultsThe arthritis index (AI) was evaluated every week to determine whether the model was successful. We defined AI score ≥4 as successful model (AI score standard:0, No swelling;1, Slight redness and swelling;2, Moderate redness and swelling of ankle; 3, Severe redness and swelling of the entire paw;4, Maximally inflamed limb with involvement of multiple joints [3]). Day 28–42, hind foot redness and swelling of the mouse continued to develop and extended to the forefoot. Compared with the normal group, incidence of CIA model group reached 100%. Day 49, compared with the model group by joint scores, medium-dose group, high-dose group and leflunomide group have Significant differences on CIA model (p<0.01). Compared with the Leflunomide group, low-dose group, medium-dose group and high-dose group have no obvious difference (p>0.05). Compared with the low-dose group, medium-dose group and high-dose group have no difference (p>0.05).Table 1.Joint scores (mean ± SD)groups28d35d42d49d aoooob8.05±1.6212.40±2.1014.68±1.7712.33±1.68c8.66±0.1411.99±0.2312.10±0.23**11.30±0.22**d7.90±0.3411.40±0.1812.80±0.20**12.00±0.13e7.40±0.2310.90±0.13*10.40±0.44**10.60±0.36**f8.80±0.2410.60±0.30*11.30±0.22**8.80±0.55**a. Blank group. b. Model group. c. Leflunomide group. d. Low-dose group. e. Medium-dose group. f. High-dose group. Compared with the model group, *p<0.05, **p<0.01.ConclusionsCIA model has a high morbidity, long duration, macroscopic pathological manifestation and irreversible ankle joint deformation, which is consistent with the progress of human RA disease and pathological damage. Medium-dose of ChuanTengTongBi decoction, high-dose and leflunomide group had inhibitory effect on the progress of arthritis, and the effect of high-dose was better than that of leflunomide group.References Brand, D.D. Rodent models of rheumatoid arthritis. Comp. Med. 55, 114–122(2005).Shen S, Yang Z, Yiyang H U, et al. The Effect of Tripterygium Wilfordii glycoside on the Expression of CD_4+CD_(25)∼(high) Regulatory T cells,Th1 and Th2 with IgA Nephropathy[J]. Chinese Journal of Integrated Traditional & Western...

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Section: Methodsmentioning

confidence: 99%

“…Furthermore, inhibition of PI3K/AKT pathway reversed TNF-α mediated autophagy and cytokine secretion. Background: DBA/1 mouse (H2 q type) CIA model as a mature model of rheumatoid arthritis is widely used in pharmacology and pharmacodynamics research [1] . Chinese medicine treatment of rheumatoid arthritis has accumulated rich experience.…”

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confidence: 99%

AB0110 Evaluation of the effect of chuantengtongbi decoction on DBA / 1 MICE cia model

Wang

Shen

et al. 2017

Abstracts Accepted for Publication

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“…Via telephone survey, it was noted that the third most common occupation was rubber and plastics processing, an occupation associated with cadmium inhalation as cadmium was used as both a pigment for colouring and a stabilising agent 8. Further, cadmium-associated occupations2 were noted. Cadmium exposure-related manufacturing occupations made up 22% of the study group’s occupations.…”

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confidence: 96%

“…It has been hypothesised that cadmium inhalation within dust or fumes may trigger RA 2. This hypothesis noted that patients with RA are significantly more likely to work in specific occupations associated with increased cadmium exposure as a result of inhalation of various dusts or fumes.…”

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confidence: 99%

Could the inhalation of cadmium and other metals in addition to textile dust inhalation account for the observed increased risk of rheumatoid arthritis in textile workers?

Mathew

James

et al. 2016

Ann Rheum Dis

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“…Cadmium exposure has been hypothesised as a trigger for RA, providing a common thread between smoking and many other known RA risk factors (Hutchinson 2015). This hypothesis is supported by a rat model that exhibited enhanced collagen-induced arthritis disease activity when exposed to high levels of cadmium (Ansari et al 2015).…”

mentioning

confidence: 99%

Comment on “Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures”

Murphy

Pay

Benham

et al. 2016

Environ Health Perspect

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Cadmium, one of the villains behind the curtain: has exposure to cadmium helped to pull the strings of seropositive rheumatoid arthritis pathogenesis all along?

Cited by 28 publications

References 43 publications

AB0110 Evaluation of the effect of chuantengtongbi decoction on DBA / 1 MICE cia model

AB0110 Evaluation of the effect of chuantengtongbi decoction on DBA / 1 MICE cia model

Could the inhalation of cadmium and other metals in addition to textile dust inhalation account for the observed increased risk of rheumatoid arthritis in textile workers?

Comment on “Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures”

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