Caenorhabditis elegans as a Useful Model for Studying Aging Mutations

Zhang, Siwen; Li, Fēi; Zhou, Tong; Wang, Guixia; Li, Zhuo

doi:10.3389/fendo.2020.554994

Cited by 139 publications

(87 citation statements)

References 95 publications

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“…However, the C. elegans genome possesses homologs of about two-thirds of all human disease genes. Thus, it is widely used as a model system for studying aging, age-related diseases[ 41 ] and neurogenerative conditions[ 42 ]. Transgenerational studies of C. elegans could therefore provide insight into the molecular pathologies and epigenetic modifications that could be accumulating across generations in humans.…”

Section: Epigenetic Modifications Identified By Transgenerational Studies Of C Elegans Relevant To Psychiatrymentioning

confidence: 99%

“…Given the strong environmental component to both PTSD and SZ, continuing research into stress-induced miRNA changes in C. elegans could be used to further our understanding of the relevant environment x gene interactions underlying the molecular pathogenesis of PTSD and SZ. Other miRNAs have been implicated in stress-related disorders such as members of the miR-34 family, which are differentially expressed in induced pluripotent stem cells derived from SZ patients[ 41 , 84 ]. Among these, and consistent with the neurodevelopmental hypothesis of SZ[ 85 ], miR-34a is a key regulator of p73 expression, a p53-family member that is implicated in neuronal differentiation[ 86 ].…”

Section: Epigenetic Modifications Identified By Transgenerational Studies Of C Elegans Relevant To Psychiatrymentioning

confidence: 99%

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Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man

Hime¹,

Stonehouse²,

Pang³

2021

WJP

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Mental illness remains the greatest chronic health burden globally with few in-roads having been made despite significant advances in genomic knowledge in recent decades. The field of psychiatry is constantly challenged to bring new approaches and tools to address and treat the needs of vulnerable individuals and subpopulations, and that has to be supported by a continuous growth in knowledge. The majority of neuropsychiatric symptoms reflect complex gene-environment interactions, with epigenetics bridging the gap between genetic susceptibility and environmental stressors that trigger disease onset and drive the advancement of symptoms. It has more recently been demonstrated in preclinical models that epigenetics underpins the transgenerational inheritance of stress-related behavioural phenotypes in both paternal and maternal lineages, providing further supporting evidence for heritability in humans. However, unbiased prospective studies of this nature are practically impossible to conduct in humans so preclinical models remain our best option for researching the molecular pathophysiologies underlying many neuropsychiatric conditions. While rodents will remain the dominant model system for preclinical studies (especially for addressing complex behavioural phenotypes), there is scope to expand current research of the molecular and epigenetic pathologies by using invertebrate models. Here, we will discuss the utility and advantages of two alternative model organisms– Caenorhabditis elegans and Drosophila melanogaster –and summarise the compelling insights of the epigenetic regulation of transgenerational inheritance that are potentially relevant to human psychiatry.

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Section: Epigenetic Modifications Identified By Transgenerational Studies Of C Elegans Relevant To Psychiatrymentioning

confidence: 99%

Section: Epigenetic Modifications Identified By Transgenerational Studies Of C Elegans Relevant To Psychiatrymentioning

confidence: 99%

Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man

Hime¹,

Stonehouse²,

Pang³

2021

WJP

View full text Add to dashboard Cite

show abstract

“…These two forms consist of five pairs of autosomes two X chromosomes (XX) in the self‐fertilizing hermaphrodite, or a single X chromosome (XO) in male animals, and a mitochondrial genome (Chen et al, 2005; Doniach & Hodgkin, 1984; Hodgkin, 1983; Stein, Sternberg, Durbin, Thierry‐Mieg, & Spieth, 2001; Yoshimura et al, 2019). This makes the nematode C. elegans one of the most widely used experimental models for biomedical research in several research fields including developmental biology, genetics, cell biology, neuroscience, and aging (Boyd, Smith, & Freedman, 2012; Kaletta & Hengartner, 2006; Kimura, Tissenbaum, Liu, & Ruvkun, 1997; Ruszkiewicz et al, 2018; Zhang, Li, Zhou, Wang, & Li, 2020).…”

Section: Archives Of C Elegans As a Host Systemmentioning

confidence: 99%

Significance of probiotics in remodeling the gut consortium to enhance the immunity of Caenorhabditis elegans

Prithika

Das

Babu

2021

Genesis

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Summary In the recent past, Caenorhabditis elegans has emerged as one of the leading nematode models for studying host–microbe interactions on molecular, cellular, or organismal levels. In general, morphological and functional similarities of the gut of C. elegans with respect to that of human has brought in speculations on the study of the intestinal microbiota. On the other hand, probiotics have proved their efficacy in metabolism, development, and pathogenesis thereby inducing an immune response in C. elegans. Nurturing C. elegans with probiotics has led to immunomodulatory effects in the intestinal microbiota, proposing C. elegans as one of the in vivo screening criteria to select potential probiotic bacteria for host health‐promoting factors. The major prospect of these probiotics is to exert longevity toward the host in diverse environmental conditions. The extent of research on probiotic metabolism has shed light on mechanisms of the immunomodulatory effect exerted by the nematode model. This review discusses various aspects of the effects of probiotics in improving the health and mechanisms involved in conferring immunity in C. elegans.

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“…The free-living and non-pathogen nematode Caenorhabditis elegans has been considered for a long time as a model organism for the study of human diseases because of its highest conservation of signaling pathways and genes responsible for the development of many illnesses, including metabolic disorders [ 8 , 9 ]. Interestingly, the genome of C. elegans was the first multicellular genome to be almost completely sequenced, and although its genome has been recompleted in recent years, to date more than 100 genes that have human orthologs have been identified, many of which are related to numerous human disorders [ 10 , 11 , 12 ]. In particular, C. elegans offers many technical and biological advantages, since its maintenance in the laboratory is very cheap and easy and experiments do not involve ethical concerns.…”

Section: Introductionmentioning

confidence: 99%

Effects of High Dietary Carbohydrate and Lipid Intake on the Lifespan of C. elegans

Franco-Juárez

Gómez-Manzo

Hernández-Ochoa

et al. 2021

Cells

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Health and lifespan are influenced by dietary nutrients, whose balance is dependent on the supply or demand of each organism. Many studies have shown that an increased carbohydrate–lipid intake plays a critical role in metabolic dysregulation, which impacts longevity. Caenorhabditis elegans has been successfully used as an in vivo model to study the effects of several factors, such as genetic, environmental, diet, and lifestyle factors, on the molecular mechanisms that have been linked to healthspan, lifespan, and the aging process. There is evidence showing the causative effects of high glucose on lifespan in different diabetic models; however, the precise biological mechanisms affected by dietary nutrients, specifically carbohydrates and lipids, as well as their links with lifespan and longevity, remain unknown. Here, we provide an overview of the deleterious effects caused by high-carbohydrate and high-lipid diets, as well as the molecular signals that affect the lifespan of C. elegans; thus, understanding the detailed molecular mechanisms of high-glucose- and lipid-induced changes in whole organisms would allow the targeting of key regulatory factors to ameliorate metabolic disorders and age-related diseases.

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Caenorhabditis elegans as a Useful Model for Studying Aging Mutations

Cited by 139 publications

References 95 publications

Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man

Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man

Significance of probiotics in remodeling the gut consortium to enhance the immunity of Caenorhabditis elegans

Effects of High Dietary Carbohydrate and Lipid Intake on the Lifespan of C. elegans

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