Caesalpinia bonduc (L.) Roxb. as a promising source of pharmacological compounds to treat Poly Cystic Ovary Syndrome (PCOS): A review

Kandasamy, Veerapandiyan; Balasundaram, Usha

doi:10.1016/j.jep.2021.114375

Cited by 26 publications

(17 citation statements)

References 30 publications

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“…Numerous research studies have been conducted to demonstrate its anti-diabetic, anti-cancer, anti-inflammatory, and anti-pyretic properties with recent studies concentrating on its antiestrogenic and anti-androgenic properties. 51 Gupta et al 52 reported that C. bonduc seeds demonstrated a significant anti-cancer property when studied using the Ehrlich ascites carcinoma model in Swiss albino mice. In this study, ethanol seed extract treated mice showed a substantial decrease in tumor size and a higher life span than the non-treated control tumor-induced mice.…”

Section: Discussionmentioning

confidence: 99%

Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats

Sasidharan¹,

KP²,

Bhaumik³

et al. 2022

RRU

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Introduction Benign prostatic hyperplasia (BPH) is a major chronic disease affecting men, and the therapeutic agents currently used to manage it have significant side effects. As a result, an alternative medicine with improved therapeutic properties with no side effects is desperately needed. The current investigation aims to study whether the Caesalpinia bonduc seed extracts (ethanolic-A, hydroalcoholic-B, and aqueous-C) have inhibitory potential on testosterone propionate (TP)-induced BPH in Wistar rats. Methods Wistar rats (male) were randomly allocated to one of five groups: control, BPH (TP-3 mg/kg, subcutaneously daily), low dose (TP + C. bonduc seed extracts – 200 mg/kg body weight), high dose (TP + C. bonduc seed extracts – 400 mg/kg body weight), and standard drug (TP + finasteride – 10 mg/kg body weight). At the end of drug treatment, the rats were sacrificed and their serum and prostates were taken for biochemical and histological studies. Results C. bonduc seed extracts treatment significantly decreased prostate weight and prostatic index in rats with TP-induced BPH. The seed extracts exhibited a potent inhibitory effect on dihydrotestosterone (DHT) in serum and prostate. In addition, the PSA level in the serum showed a noteworthy decrease in comparison with the BPH group. Histopathological examination also indicated that extracts improved the tissue morphology of the prostate significantly. Out of three extracts tested, ethanolic and hydroalcoholic extract recorded significant effect. Finally, liquid chromatography quadrupole time-of-flight mass spectrometry (LC/MS-QTOF) analysis showed that the major compounds present in the extracts were tocopherols, fucosterol, linoleic acid, β-amyrin, β-sitosterol, campesterol, cassane furanoditerpene, norcassane furanoditerpene and other diterpenes. Conclusion Thus, C. bonduc seed extracts could be a potential source for the formulation of new drug for managing BPH. To the best of our knowledge, this is the first scientific animal investigation into the use of C. bonduc seed extract for the management of BPH.

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Section: Discussionmentioning

confidence: 99%

Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats

Sasidharan¹,

KP²,

Bhaumik³

et al. 2022

RRU

View full text Add to dashboard Cite

show abstract

“…, 2011 ). Recently, the studies on seed extraction showed that C. bonduc contains antioxidant properties that can be used to prevent the lipid peroxidation of the cell membrane and the management of polycystic ovary syndrome ( Suhani et al., 2019 ; Meera et al., 2020 ; Sumithra et al., 2021 ; Kandasamy and Balasundaram, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Predicting the potential impacts of climate change on the endangered Caesalpinia bonduc (L.) Roxb in Benin (West Africa)

Wouyou

Lokonon

Idohou

et al. 2022

Heliyon

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“…For instance, phanginin D triggers apoptosis by activating caspase-3, phanginin R induces apoptosis by enhancing the (PARP) activity, and procaspase-3 cleavage also increases the ratio of Bax/Bcl-2 and the p53 protein expression [ 23 , 24 ]. Additionally, caesalpin G induces apoptosis via another apoptotic mechanism, promoting ER stress and suppressing the Wnt/β-catenin signaling pathway [ 3 , 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds

et al. 2022

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A set of thirteen cassane-type diterpenes was synthesized and an expedient synthetic route was used to evaluate 14-desmethyl analogs of the most active tested cassane. The anti-inflammatory activities of these 13 compounds were evaluated on a lipopolysaccharide (LPS)-activated RAW 264.7 cell line by inhibition of nitric oxide (NO) production, some of them reaching 100% NO inhibition after 72 h of treatment. The greatest anti-inflammatory effect was observed for compounds 16 and 20 with an IC50 NO of 2.98 ± 0.04 μg/mL and 5.71 ± 0.14 μg/mL, respectively. Flow-cytometry analysis was used to determine the cell cycle distribution and showed that the inhibition in NO release was accompanied by a reversion of the differentiation processes. Moreover, the anti-cancer potential of these 13 compounds were evaluated in three tumor cell lines (B16-F10, HT29, and Hep G2). The strongest cytotoxic effect was achieved by salicylaldehyde 20, and pterolobirin G (6), with IC50 values around 3 μg/mL in HT29 cells, with total apoptosis rates 80% at IC80 concentrations, producing a significant cell-cycle arrest in the G0/G1 phase, and a possible activation of the extrinsic apoptotic pathway. Additionally, initial SAR data analysis showed that the methyl group at the C-14 positions of cassane diterpenoids is not always important for their cytotoxic and anti-inflammatory activities.

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Caesalpinia bonduc (L.) Roxb. as a promising source of pharmacological compounds to treat Poly Cystic Ovary Syndrome (PCOS): A review

Cited by 26 publications

References 30 publications

Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats

Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats

Predicting the potential impacts of climate change on the endangered Caesalpinia bonduc (L.) Roxb in Benin (West Africa)

Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds

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