Caesalpinone A, a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, from the pods of Caesalpinia spinosa Kuntze

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“…Caesalpinone A 10, from pods of Caesalpinia spinosa, is the first example of a 1,15-cyclised gorgonane sesquiterpenoid. 7 A terpene cyclase from Streptomyces pristinaespiralis produces a sesquiterpenoid with a novel framework, pristinol 11. 8 The structure of pristinol 11 was confirmed by X-ray analysis.…”

Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics

“…The complexity of the active compounds present in the aqueous and ethanolic extracts of C. spinosa pods remains unresolved. In general, polyphenols, flavonoids, tannic acids, and gallic acids (Aguilar-Galvez et al, 2014;Mu et al, 2016), along with 10 types of sesquiterpenoids, have been identified in the extract of mature pods, including Caesalpinin A(1) (Mu et al, 2016) in extracts of immature pods, galactomannan (polysaccharides) (Santander et al, 2011;Skowyra et al, 2013) in seed endosperm, and diterpenes in extracts of leaves (He et al, 2015). From our results, it can be inferred that as long as the structure and function of normal cells were maintained, there was no risk of DNA damage due to the active compounds from C. spinosa aqueous extract.…”