“…Out of ten available safeguards, the lowest count achieved was six, [50][51][52] and the highest count was 10. 40,41,44,53 Only a few of the studies mentioned the representativeness for the national population, 25,27,40,41,43,44,53,54 and some did not discuss representativeness against the target population, 26,28,45,46,[48][49][50][51][52][55][56][57][58][59][60] which jeopardised the external validity. The outcome definition for CDMR did not match in four articles, where previous CD was included as a reason for CDMR.…”