Cafeteria diet-induced obesity reduces leptin-stimulated NADPH-diaphorase reactivity in the hypothalamic arcuate nucleus of rats

Hristov, Milen; Landzhov, Boycho; Yakimova, K

doi:10.1016/j.acthis.2020.151616

Cited by 10 publications

(6 citation statements)

References 56 publications

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“…In the present study, the HC diet promoted glycolysis and gluconeogenesis, but these processes decreased with the addition of MI in the feed. Simultaneously, the addition of MI promotes the activities of glucose in the pentose phosphate pathway [52][53][54]. In the current study, MI might change glucose to the pentose phosphate pathway.…”

Section: Discussionmentioning

confidence: 54%

Alleviation of the Adverse Effect of Dietary Carbohydrate by Supplementation of Myo-Inositol to the Diet of Nile Tilapia (Oreochromis niloticus)

Zhu

Pan

Wang

et al. 2020

Animals

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This study investigated the effect of dietary myo-inositol (MI) on alleviating the adverse effect of the high carbohydrate diet in Nile tilapia (Oreochromis niloticus). Six diets contained either low carbohydrate (LC 30%) or high carbohydrate (HC 45%) with three levels of MI supplementation (0, 400 and 1200 mg/kg diet) to each level of the carbohydrate diet. After an 8-week trial, the fish fed 400 mg/kg MI under HC levels had the highest weight gain and fatness, but the fish fed 1200 mg/kg MI had the lowest hepatosomatic index, visceral index and crude lipid in the HC group. The diet of 1200 mg/kg MI significantly decreased triglyceride content in the serum and liver compared with those fed the MI supplemented diets regardless of carbohydrate levels. Dietary MI decreased triglyceride accumulation in the liver irrespective of carbohydrate levels. The content of malondialdehyde decreased with increasing dietary MI at both carbohydrate levels. Fish fed 1200 mg/kg MI had the highest glutathione peroxidase, superoxide dismutase, aspartate aminotransferase and glutamic-pyruvic transaminase activities. The HC diet increased the mRNA expression of key genes involved in lipid synthesis (DGAT, SREBP, FAS) in the fish fed the diet without MI supplementation. Dietary MI significantly under expressed fatty acid synthetase in fish fed the HC diets. Moreover, the mRNA expression of genes related to lipid catabolism (CPT, ATGL, PPAR-α) was significantly up-regulated with the increase of dietary MI levels despite dietary carbohydrate levels. The gene expressions of gluconeogenesis, glycolysis and MI biosynthesis were significantly down-regulated, while the expression of the pentose phosphate pathway was up-regulated with the increase of MI levels. This study indicates that HC diets can interrupt normal lipid metabolism and tend to form a fatty liver in fish. Dietary MI supplement can alleviate lipid accumulation in the liver by diverging some glucose metabolism into the pentose phosphate pathway and enhance the antioxidant capacity in O. niloticus.

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Section: Discussionmentioning

confidence: 54%

Alleviation of the Adverse Effect of Dietary Carbohydrate by Supplementation of Myo-Inositol to the Diet of Nile Tilapia (Oreochromis niloticus)

Zhu

Pan

Wang

et al. 2020

Animals

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“…In WD-fed rats, hyperleptinaemia induces hypothalamic leptin resistance, which decreases neural signals to stimulate satiety and pro-thermogenic and energy expenditure. [14][15][16][17] Therefore, at least for the WD-EXE and WD-EXE-VD groups, exercise-induced reductions in leptinaemia may have improved these neural circuitries to enhance energy expenditure. Possibly, at least during the first weeks of the experimental period, the improved leptin sensitivity accounted for the reductions in food intake in both exercised CTL and WD-fed rats.…”

Section: Discussionmentioning

confidence: 99%

“…Results indicate that such pathways may have been stimulated by swim exercise in the WD‐EXE and CTL‐EXE rats, independently of Vit D supplementation, because these exercised rodents displayed significantly lower leptinaemia. In WD‐fed rats, hyperleptinaemia induces hypothalamic leptin resistance, which decreases neural signals to stimulate satiety and pro‐thermogenic and energy expenditure 14‐17 . Therefore, at least for the WD‐EXE and WD‐EXE‐VD groups, exercise‐induced reductions in leptinaemia may have improved these neural circuitries to enhance energy expenditure.…”

Section: Discussionmentioning

confidence: 99%

“…The ingestion of the WD by rodents increases body fat mass and causes metabolic dysfunctions similar to those observed in obese humans. [13][14][15][16][17] To the best of our knowledge, there is currently no evidence to determine whether Vit D supplementation may be a useful strategy to enhance physical exercise benefits against adiposity and obesity comorbidities. Therefore, we hypothesized that swimming ET, beginning early on in life, may prevent/attenuate the obesity induced by WD intake in male rats.…”

Section: Introductionmentioning

confidence: 99%

“…This diet is composed of highly palatable and hypercaloric ultra‐processed foods. The ingestion of the WD by rodents increases body fat mass and causes metabolic dysfunctions similar to those observed in obese humans 13‐17 . To the best of our knowledge, there is currently no evidence to determine whether Vit D supplementation may be a useful strategy to enhance physical exercise benefits against adiposity and obesity comorbidities.…”

Section: Introductionmentioning

confidence: 99%

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Physical exercise attenuates obesity development in Western‐diet fed obese rats independently of vitamin D supplementation

Cordeiro

Ribeiro

Bubna

et al. 2022

Clin Exp Pharma Physio

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Physical inactivity, associated with the ingestion of hypercaloric foods, contributes to obesity development. In contrast, physical exercise training (ET) can slow obesity progression. Vitamin (Vit) D, a hormone that regulates adipocyte metabolism, may represent a strategy to reduce obesity; however, it is currently not known whether Vit D enhances the anti-obesity benefits of physical exercise. We hypothesized that swimming ET may prevent Western diet (WD)-induced obesity, and that Vit D supplementation could enhance the anti-obesity actions of ET. Male Wistar rats were fed, from 21 to 90 days of age, on a standard diet, or a WD, in association or not (sedentary control [CTL-SED] and WD [WD-SED] groups) with swimming ET for 15 min/day, 3 days a week (exercised CTL [CTL-EXE] and WD [WD-EXE] groups). Additionally, at 60 days of age, half of the CTL-EXE and WD-EXE groups were submitted, or not, to oral Vit D supplementation (CTL-EXE-VD and WD-EXE-VD groups, respectively). At 91 days old, WD-SED rats displayed increased body weight, abdominal adiposity, hypercholesterolemia, hyperleptinaemia and high circulating levels of tumour necrosis factor (TNF)-α. Swimming ET attenuated the increase in abdominal adiposity induced by WD. Furthermore, the WD-EXE group exhibited reductions in glycaemia, triglyceridaemia, cholesterolaemia, leptinaemia and in plasma TNF-α concentrations. Vitamin D supplementation, combined with ET, did not provide any additive benefit against adiposity, only potentiating the effects of ET action on the reduction in triglyceridaemia. Exercise training, independently of Vit D, provides a strategy to attenuate the adiposity expansion that is induced by WD, mediated in part by reductions in leptinaemia and TNF-α levels.

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Alterations of the glutamatergic system in diabetes mellitus

Hristov,

Nankova,

Andreeva-Gateva

2023

Metab Brain Dis

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Cafeteria diet-induced obesity reduces leptin-stimulated NADPH-diaphorase reactivity in the hypothalamic arcuate nucleus of rats

Cited by 10 publications

References 56 publications

Alleviation of the Adverse Effect of Dietary Carbohydrate by Supplementation of Myo-Inositol to the Diet of Nile Tilapia (Oreochromis niloticus)

Alleviation of the Adverse Effect of Dietary Carbohydrate by Supplementation of Myo-Inositol to the Diet of Nile Tilapia (Oreochromis niloticus)

Physical exercise attenuates obesity development in Western‐diet fed obese rats independently of vitamin D supplementation

Alterations of the glutamatergic system in diabetes mellitus

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