Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice

Mallik, Sanchari Basu; Mudgal, Jayesh; Nampoothiri, Madhavan; Hall, Susan; Dukie, Shailendra; Grant, Gary; Rao, C. Mallikarjuna; Arora, Devinder

doi:10.1016/j.neulet.2016.08.044

Cited by 77 publications

(44 citation statements)

References 34 publications

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“…We and others have previously shown that Desip or its precursor imipramine block depression-like behaviors of mice (Basu Mallik et al, 2016; Elgarf et al, 2014; Jain et al, 2001; Mello et al, 2013; O’Leary et al, 2007; Park et al, 2011; Platt et al, 2013; Shen et al, 1999; Tomaz et al, 2014), and that Ido1 is necessary for murine depression-like behavior (Lawson et al, 2013; O’Connor et al, 2009b; O’Connor et al, 2009c; Salazar et al, 2012). With the current data, we highlight a new putative mechanism for Desip’s anti-depressant activity: decreasing Ido1 and Ido2 expression within the brain and periphery.…”

Section: Discussionmentioning

confidence: 94%

“…Desipramine (Desip; a tricyclic serotonin/norepinephrine reuptake inhibitor) is a commonly prescribed anti-depressant. In preclinical studies, Desip or its precursor imipramine decreased depression-like behavior of LPS-treated (Basu Mallik et al, 2016; Elgarf et al, 2014; Jain et al, 2001; Mello et al, 2013; Park et al, 2011; Shen et al, 1999; Tomaz et al, 2014) and BCG-infected mice (Platt et al, 2013; Vijaya Kumar et al, 2014). Many such studies attributed the induction of depression-like behaviors to Ido1, but no data were provided to determine if Desip altered DO expression as a mechanism associated with diminished depression-like behaviors.…”

Section: Introductionmentioning

confidence: 99%

“…Many such studies attributed the induction of depression-like behaviors to Ido1, but no data were provided to determine if Desip altered DO expression as a mechanism associated with diminished depression-like behaviors. As previous work has shown that Desip or its precursor imipramine can decrease LPS-induced depression-like activity (Basu Mallik et al, 2016; Elgarf et al, 2014; Jain et al, 2001; Mello et al, 2013; Park et al, 2011; Shen et al, 1999; Tomaz et al, 2014), we investigated the relationship between inflammation, Desip and DO expression.…”

Section: Introductionmentioning

confidence: 99%

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Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases

Brooks

Janda

Lawson

et al. 2017

Brain, Behavior, and Immunity

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Abundant evidence connects depression symptomology with immune system activation, stress and subsequently elevated levels of kynurenine. Anti-depressants, such as the tricyclic norepinephrine/serotonin reuptake inhibitor desipramine (Desip), were developed under the premise that increasing extracellular neurotransmitter level was the sole mechanism by which they alleviate depressive symptomologies. However, evidence suggests that anti-depressants have additional actions that contribute to their therapeutic potential. The Kynurenine Pathway produces tryptophan metabolites that modulate neurotransmitter activity. This recognition identified another putative pathway for anti-depressant targeting. Considering a recognized role of the Kynurenine Pathway in depression, we investigated the potential for Desip to alter expression of rate-limiting enzymes of this pathway: indoleamine-2,3-dioxygenases (Ido1 and Ido2). Mice were administered lipopolysaccharide (LPS) or synthetic glucocorticoid dexamethasone (Dex) with Desip to determine if Desip alters indoleamine-dioxygenase (DO) expression in vivo following a modeled immune and stress response. This work was followed by treating murine and human peripheral blood mononuclear cells (PBMCs) with interferon-gamma (IFNγ) and Desip. In vivo: Desip blocked LPS-induced Ido1 expression in hippocampi, astrocytes, microglia and PBMCs and Ido2 expression by PBMCs. Ex vivo: Desip decreased IFNγ-induced Ido1 and Ido2 expression in murine PBMCs. This effect was directly translatable to the human system as Desip decreased IDO1 and IDO2 expression by human PBMCs. These data demonstrate for the first time that an anti-depressant alters expression of Ido1 and Ido2, identifying a possible new mechanism behind anti-depressant activity. Furthermore, we propose the assessment of PBMCs for anti-depressant responsiveness using IDO expression as a biomarker.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases

Brooks

Janda

Lawson

et al. 2017

Brain, Behavior, and Immunity

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“…Recent in vivo studies mainly focused on neurodegenerative disease (e.g. Alzeimer's), obesity and diabetes, skin cancer, and liver and kidney damage (Table ).…”

Section: Mechanism Of Action Of Hydroxycinnamic Acids: Recent Advancesmentioning

confidence: 99%

“…[118][119][120] Recent in vivo studies mainly focused on neurodegenerative disease (e.g. Alzeimer's), [121][122][123][124][125][126][127] obesity and diabetes, [128][129][130] skin cancer, [131][132][133] and liver 134 and kidney damage 135 (Table 4).…”

Section: Caffeic Acid: Recent Advancesmentioning

confidence: 99%

Hydroxycinnamic acids and human health: recent advances

2019

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There is an urgent need to improve human diet globally. Compelling evidence gathered over the past several decades suggests that a suboptimal diet is associated with many chronic diseases and may be responsible for more deaths than any other risks worldwide. The main components in our diet that need higher intake are whole grains, fruit and vegetables, and nuts and seeds; all of these are important sources of dietary fiber and polyphenols. The health benefits of dietary fiber and polyphenols are also supported by several decades of valuable research. However, the conclusions drawn from interventional human trials are not straightforward and the action mechanisms in improving human health are not fully understood. Moreover, there is a great inter‐individual variation caused by different individual capabilities of processing, absorbing and using these compounds effectively. Data on the bioavailability and bioefficacy of hydroxycinnamic acids (HCAs) are limited when compared to other classes of polyphenols (e.g. anthocyanins). This review aims to summarize the latest research advances related to HCA bioavailability and their biological effects revealed by epidemiological data, pre‐clinical and clinical studies. Moreover, we aim to review the effects of HCAs on gut microbiota diversity and function and its respective influence on host health. © 2019 Society of Chemical Industry

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Polyphenols for Pharmacological Applications

Dowlatshah,

Ramos‐Payán

2024

Biopolymers in Pharmaceutical and Food Applications

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Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice

Cited by 77 publications

References 34 publications

Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases

Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases

Hydroxycinnamic acids and human health: recent advances

Polyphenols for Pharmacological Applications

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