Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro

Saivish, Marielena Vogel; Pacca, Carolina Colombelli; Costa, Vivaldo Gomes da; Silva, Roosevelt Alves da; Nebo, Liliane; Silva, Gislaine Celestino Dutra da; Milhim, Bruno Henrique Gonçalves de Aguiar; Teixeira, Igor da Silva; Henrique, Tiago; Mistrão, Natalia Franco Bueno; Hernandes, Victor Miranda; Zini, Nathalia; Carvalho, Ana Carolina de; Fontoura, Marina Alves; Rahal, Paula; Sacchetto, Lívia; Marques, Rafael Elias; Nogueira, Maurício Lacerda

doi:10.3390/v15020494

Cited by 13 publications

(4 citation statements)

References 84 publications

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“…The regulation of targets by miRNAs is an important feature in various viruses, including ILHV [14]. Through comparative analyses, it has been observed that some miRNAs previously associated with the ILHV viral genome may also have homologs or similar targets in other viruses.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Interactions between Human microRNAs and the Ilheus Virus Genome

Souza,

Casseb

2023

SynBio

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MicroRNAs (miRNAs) are small non-coding RNA molecules that play a fundamental role in the regulation of gene expression in humans. There has been a growing interest in investigating the interactions between human miRNAs and viruses to better understand the underlying mechanisms of the immune response and viral pathogenesis. The Ilheus virus, an arbovirus transmitted by mosquitoes, is known to cause disease in humans, with symptoms ranging from mild fever to severe neurological complications. This scientific article aims to explore the potential role of human miRNAs in their association with the genome of the Ilheus virus. Previous research has indicated that miRNAs can affect viral replication and the host’s immune response, playing a critical role in modulating the virus–host interaction. Here, we will investigate the possible interactions between specific human miRNAs and regions of the Ilheus virus genome, focusing on identifying miRNAs that may impact viral replication or the host’s immune response. A search for potential human miRNAs associated with the viral genome of ILHV was conducted through database searches such as miRBase. For the elucidation of targets regulated by these miRNAs, the TargetScan program was adopted. Functional enrichment analysis, inferring the function of genes regulated by miRNAs, was provided by the DAVID software. To elucidate the secondary structure, tools hosted in the RNAFold repositories were employed. In summary, our research has identified miRNAs linked to crucial sections of the Ilheus virus genome. These miRNAs can potentially regulate genes associated with neurological and immune functions. This highlights the intricate interplay between human miRNAs and the Ilheus virus genome, suggesting a pivotal role for these molecules in the host’s response to viral infections.

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Section: Discussionmentioning

confidence: 99%

Exploring the Interactions between Human microRNAs and the Ilheus Virus Genome

Souza,

Casseb

2023

SynBio

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“…Caffeic acid, a metabolite derived from chlorogenic acid, is also described in the literature as a phenolic compound found in coffee's silver skin (Figure 5). Despite possessing a lower commercial value compared to CQAs (1 g of caffeic acid equivalent to $50), it boasts a wide range of biological activities, including antioxidant, antiviral, anticancer, antiplasmodial, and antidiabetic properties [93][94][95].…”

Section: Coffee (Coffea Spp)mentioning

confidence: 99%

“…$50), it boasts a wide range of biological activities, including antioxidant, antiviral, anticancer, antiplasmodial, and antidiabetic properties [93][94][95].…”

Section: Citrus (Citrus Spp)mentioning

confidence: 99%

High Added-Value by-Products from Biomass: A Case Study Unveiling Opportunities for Strengthening the Agroindustry Value Chain

Dos Santos,

Barcellos-Silva,

Leite-Barbosa

et al. 2024

Biomass

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The current era witnesses a remarkable advancement in biomass utilization, guided by the principles of green chemistry and biorefinery and the comprehensive exploitation of plant-based raw materials. Predominantly, large-scale production methods have been pursued, akin to approaches in the oil industry, enabling the incorporation of novel products into energy and petrochemical markets. However, the viability of such systems on a small and medium scale is hindered by logistical challenges and the constraints of economies of scale. For small agricultural producers and food processing companies, the complete utilization of biomass transcends environmental responsibility, evolving into a strategy for survival through the diversification of by-products with enhanced value. The state of Rio de Janeiro in Brazil presents a range of population dynamics, geographical features, climate conditions, and agricultural production patterns that closely resemble those found in various tropical countries and agricultural regions worldwide. This region, sustaining a green belt supporting 17 million people, provides an apt case study for investigating chemical compounds with potential value among agro-industrial residues, which can motivate the creation of a lucrative biotechnological industry. Examples include naringenin and hesperidin from oranges and lemons, epi-gallo-catechin gallate from bananas, caffeic acids from coffee, and the bromelain enzyme from pineapples. This study addresses the challenges associated with developing biotechnological alternatives within the agroindustry, considering economic, technological, logistical, and market-related aspects. The insights from examining the Brazilian state of Rio de Janeiro will contribute to the broader discourse on sustainable biomass utilization and the creation of value-added by-products.

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“…Molecules 2023, 28, 7182 2 of 12 documented that caffeic acid exhibited an extensive range of biological activities such as antioxidant [11], antiviral [12], anticancer [13], antiplasmodial [14], and antidiabetic properties [15,16]. Previous studies have found that caffeic acid has various diabetesrelieving mechanisms, including improving glucose homeostasis as well as pancreatic β-cell function [16], suppressing hepatic nuclear factor-4 (HNF-4), and decreasing phosphoenolpyruvate carboxykinase (PEPCK) activity to maintain glucose homeostasis [17].…”

Section: Introductionmentioning

confidence: 99%

Caffeic Acid in Spent Coffee Grounds as a Dual Inhibitor for MMP-9 and DPP-4 Enzymes

Istyastono,

Yuniarti,

Prasasty

et al. 2023

Molecules

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Type 2 diabetes mellitus and diabetic foot ulcers remain serious worldwide health problems. Caffeic acid is one of the natural products that has been experimentally proven to have diverse pharmacological properties. This study aimed to assess the inhibitory activity of caffeic acid and ethanolic extract of spent coffee grounds targeting DPP-4 and MMP-9 enzymes and evaluate the molecular interactions through 50-ns molecular dynamics simulations. This study also introduced our new version of PyPLIF HIPPOS, PyPLIF HIPPOS 0.2.0, which allowed us to identify protein–ligand interaction fingerprints and interaction hotspots resulting from molecular dynamics simulations. Our findings revealed that caffeic acid inhibited the DPP-4 and MMP-9 activity with an IC50 of 158.19 ± 11.30 µM and 88.99 ± 3.35 µM while ethanolic extract of spent coffee grounds exhibited an IC50 of 227.87 ± 23.80 µg/100 µL and 81.24 ± 6.46 µg/100 µL, respectively. Molecular dynamics simulations showed that caffeic acid interacted in the plausible allosteric sites of DPP-4 and in the active site of MMP-9. PyPLIF HIPPOS 0.2.0 identified amino acid residues interacting more than 10% throughout the simulation, which were Lys463 and Trp62 in the plausible allosteric site of DPP-4 and His226 in the active site of MMP-9.

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Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro

Cited by 13 publications

References 84 publications

Exploring the Interactions between Human microRNAs and the Ilheus Virus Genome

Exploring the Interactions between Human microRNAs and the Ilheus Virus Genome

High Added-Value by-Products from Biomass: A Case Study Unveiling Opportunities for Strengthening the Agroindustry Value Chain

Caffeic Acid in Spent Coffee Grounds as a Dual Inhibitor for MMP-9 and DPP-4 Enzymes

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