Caffeic Acid Loading Wound Dressing: Physicochemical and Biological Characterization

Abstract

The hydrogels obtained could be useful as caffeic acid delivery-system devices for the treatment of wound infections.

Smart Hydrogel for the pH‐Selective Drug Delivery of Antimicrobial Compounds

“…The following peaks were identified on the HPMC spectrum: 3442 cm −1 (O‐H stretching), 2936 cm −1 (stretching vibrational asymmetric of C‐H), 1652 cm −1 (hydrogen interactions), and 1060 cm −1 (ether bond). The stronger intensity peaks observed for the HPβCD were 3440 cm −1 (O‐H stretching), 2930 cm −1 (stretching vibrational asymmetric of C‐H), 1640 cm −1 (hydrogen interactions), 1115 cm −1 (C‐O stretching) and 1040 cm −1 (C‐O‐C) . The hydrogels spectra were identical and it was possible to confirm the formation of intermolecular bounds between the monomers.…”

“…The hydrogels were obtained thought the crosslinking of HPMC, HPβCD and CS. Cyclodextrins based hydrogels using HPMC and HPβCD, crosslinking with BDGE, were successfully obtained by Pinho et al The materials showed suitable properties for drug delivery and wound treatment . In the present work, CS was used to introduce a new feature to the hydrogel, pH‐sensitivity.…”

“…Nevertheless, HPMC‐HPβCD‐CS, HPβCD‐CS, HPMC‐CS and the powders HPMC, HPβCD and CS, were characterized by FTIR (Figure ), DSC (Figure A) and TGA (Figure B). The HPMC‐HPβCD physicochemical characterization was, already, described …”

“…This hydrogel was able to accommodate 0.4 g CA /g hydrogel (pH 5, H 3 PO 4 /NaOH buffer) and sustained the delivery for 48h (0.77 mg CA /g hydrogel , pH 5, synthetic sweat solution). Caffeic acid antimicrobial activity, against bacteria, normally isolated from infected wounds, was preserved, as well as phenolic acid biocompatibility …”

Cotton‐hydrogel composite for improved wound healing: Antimicrobial activity and anti‐inflammatory evaluation—Part 2

“…Antimicrobial wound dressings have been often used to protect the wound from new injury, dehydration, and microorganism deposition . Several materials (textiles, hydrogels, foams, and films) have been developed to deliver antimicrobial agents to infected wounds . Although, they still show inadequate release profile, characterized by an initial burst that leads to local toxicity owed high antimicrobial concentration, followed by a prolonged release of antimicrobial agent below required concentration, selecting the resistant microorganisms …”