Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity

Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated fromRhus vernicifluain LPS-stimulated BV2 Microglial Cells

“…Numerous ester derivatives of caffeic acid such as CAPE [21], chlorogenic acid [26], pedicularioside A [27], forsythoside B [28], and echinachoside [29] exhibit a wide range of biological activities including antioxidant and anti-inflammatory properties, inhibition of caspase-3, and maintenance of mitochondrial function. However, ester derivatives of caffeic acid with high molecular weight aliphatic alcohols such as DC and 1-eicosanoyl cafferate have rarely been isolated.…”

“…Ester derivatives of caffeic acid also exhibit various biological activities [20]. For example, caffeic acid phenylethyl ester (CAPE), an antioxidant component of propolis, protects against glutamate-induced neurotoxicity [21] and cerebral ischemia [22]. Although DC was previously identified in the root of Sohora subprostrata [23], its biological activity was never demonstrated.…”

Can propolis be protective against ethanol-impaired anxiety and unconditional fear?

“…Researcher reported that caffeic acid and terpenoids act through multiple mechanism involving free radical scavenging, metalic ion chelation and inhibitory actions on specific enzymes that induce free radical and lipid hydroperoxide formation, anti-inflammatory activity, inhibition of excitotoxicity, inhibition of cell progression [1,19,21].…”

Cytoprotective Effects of Docosyl Cafferate against tBHP-Induced Oxidative Stress in SH-SY5Y Human Neuroblastoma Cells

“…Numerous ester derivatives of caffeic acid such as CAPE, chlorogenic acid, pedicularioside A, forsythoside B, and echinachoside have been reported to exhibit biological activities such as antioxidant and anti-infl ammatory properties, inhibition of caspase-3, and maintenance of mitochondrial function (Deng et al, 2004;Jiang et al, 2010;Lapchak, 2007;Li et al, 2008;Wei et al, 2008). Although ester derivatives of caffeic acid with high molecular weight aliphatic alcohol such as DC and 1-eicosanoyl cafferate have been isolated from sophora Localization of NF-kB p65 subunit was determined using a p65 antibody and an Alexa 546-labeled goat anti-rabbit IgG antibody.…”

“…Ester derivatives of caffeic acid have also been reported to possess numerous biological activities (Kim, 2010). For example, caffeic acid phenylethyl ester (CAPE) Ther 19(2), 195-200 (2011) has been reported to possess protective activities against glutamate-induced neurotoxicity (Wei et al, 2008) and cerebral ischemia (Tsai et al, 2006). Although DC was previously identifi ed in the root of Sohora subprostrata (Komatsu et al, 1970), its biological activity has never been demonstrated.…”