Caffeic acid protects against IL-1β-induced inflammatory responses and cartilage degradation in articular chondrocytes

Huang, Xiaojian; Xi, Yong; Pan, Quan-Ke; Mao, Zekai; Zhang, Rui; Ma, Xiaohu; You, Hongbo

doi:10.1016/j.biopha.2018.07.161

Cited by 42 publications

(39 citation statements)

References 31 publications

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“…Oxidative stress is considered as a progenitor in osteoarthritis. The prevention of oxidative stress has been reported to prevent the osteoarthritic conditions in animal models [ 5 , 6 , 9 ]. From the results, it was clearly observed that the level of lipid peroxidation was elevated whereas the levels of enzymatic and non-enzymatic antioxidants were reduced in the CFA-induced model rats indicating that the rats were under oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…There are measures to overcome the pain in osteoarthritic patients but the need to prevent cartilage degeneration is preferred as a potential solution for osteoarthritis. Previous reports have suggested attenuation of inflammation and oxidative stress could be beneficial in prevention of damage to articular cartilage [ 8 - 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Plants are natural sources of antioxidants that are acclaimed for numerous medicinal and pharmacological values including anti-inflammatory and oxidative stress preventing effects [ 9 , 10 ]. Given the involvement of oxidative stress and inflammatory response in the pathogenesis of osteoarthritis, importance was specified to plant-derived antioxidant compounds as the potential solution.…”

Section: Introductionmentioning

confidence: 99%

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Anti-arthritic activity of D-carvone against complete Freund’s adjuvant-induced arthritis in rats through modulation of inflammatory cytokines

Chen

Song

et al. 2020

Korean J Physiol Pharmacol

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Chronic joint pain due to loss of cartilage function, degradation of subchondral bone, and related conditions are common plights of an arthritis patient. Antioxidant compounds could solve the problems in arthritic condition. The objective of this study was to evaluate the anti-arthritic activity of D-carvone against complete Freund’s adjuvant (CFA)-induced arthritis in rats. D-carvone was orally administered for 25 days at the doses of 30 and 60 mg/kg against CFA-induced arthritic rats. Changes in body weight, paw swelling, organ index, hematological parameters, oxidative stress markers, inflammatory cytokines, and histopathology were recorded. Oral treatment of D-carvone significantly improved the body weight, reduced the paw swelling, edema formation, and organ index in arthritic rats. The levels of white blood cells were reduced, red blood cells and hemoglobin levels were improved in D-carvone treated arthritic rats. Lipid peroxidation levels were lowered whereas enzymatic and non-enzymatic antioxidants were significantly elevated by D-carvone administration against arthritic rats. D-carvone significantly modulated inflammatory cytokine levels and improved the ankle joint pathology against CFA-induced arthritic inflammation. In conclusion, D-carvone proved significant anti-arthritic activity against CFA-induced arthritis in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-arthritic activity of D-carvone against complete Freund’s adjuvant-induced arthritis in rats through modulation of inflammatory cytokines

Chen

Song

et al. 2020

Korean J Physiol Pharmacol

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“…As a result, the survival of chondrocytes and their phenotypic stability and anabolic/catabolic balance activity are important for the maintenance of articular cartilage [27]. We further analyzed the changes of chondrocyte gene expression under the action of oligostilbenes, including matrix metalloproteinase 13(MMP13), an enzyme that is involved in the degradation of extracellular matrix (ECM) in OA [28]; COL2A1, the gene that provides type II collagen, which is the main protein in ECM of chondrocytes [29]; SOX9, an important factor in promoting cartilage differentiation, and its expression is decreased in OA patients [30]. We found that they all have the ability to inhibit the ECM degradation of chondrocytes and promote the expression of chondrocyte-specific genes.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

Cen

Liu

et al. 2019

BMC Chemistry

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Background: Paeonia suffruticosa is an important traditional Chinese herb used to treat osteoarthritis (OA) and oligostilbenes are the main active ingredient of the seeds of P. suffruticosa. The monomer trans-resveratrol of this species was demonstrated to have chondroprotective effects as a lead compound for the treatment of osteoarthritis, but it has not been applied due to its low efficacy. Methods: Oligostilbenes were isolated by chromatography and were identified by NMR and HPLC. A rabbit osteoarthritis chondrocyte model was induced by interleukin-1β and was treated with individual drugs to systematically evaluate their effects. Cell Counting Kit 8 was used to test their effects on cell viability, calculate EC 50 and plot a doseresponse curve.Their effects on apoptosis were analyzed by Annexin V and PI staining, and the expression of chondrocyte-specific genes COL2A1, MMP13 and SOX9 was evaluated by real-time PCR. Results: Paeonia suffruticosa seed extract could promote the cell viability of rabbit OA chondrocytes at low concentration and then ten oligostilbenes were isolated from it. Trans-oligostilbenes were better than their cis-forms, trimers and dimers were better than monomers for promoting the cell viability of rabbit osteoarthritis chondrocytes. None of the oligostilbenes was more effective than seed extract at the appropriate concentration; 1 μM oligostilbenes all showed various anti-apoptotic effects. Trans-gnetin H showed the best effect on proliferation and inhibition of MMP13 expression on OA chondrocytes, while trans-viniferin was most effective in promoting the expression of COL2A1 and SOX9. Conclusions: Ten oligostilbenes from P. suffruticosa seed all have certain protective effects on OA chondrocytes at low concentration. The trans-viniferin and some trimers have the potential to be further developed for the treatment of osteoarthritis because they were more effective than resveratrol and diacerein. The synergistic effect that may exist between oligostilbenes also warrants further research.

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“…These effects could be compared with the others reported by the scientific literature for compounds used as anti-cytokines agents in osteoarthritic therapy: glucosamine (23), schisandrin A (24), caffeic acid (25), diacerein (26) etc.…”

Section: Discussionmentioning

confidence: 99%

The pharmaceutic capitalization of a natural, marine active principle through in vitro anti-citokinic and proliferative mechanisms of HC-OA osteoarthritic chondrocytes

Olariu¹,

Dumitriu²,

Papacocea³

et al. 2019

Ro J Med Pract.

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Osteoarthritis (OA) as a multi-factorial disease that features interrelated mechanisms (senescence/ apoptosis, proliferation, decreased synthesis of matrix proteins, activation of degrading enzymes, inflammation) and a diversity of cells involved in bone and cartilage metabolism: chondrocytes, osteoblasts, osteoclasts etc. A complete pharmaceutical solution remains an unsolved question in this interdisciplinary field of research.We focused our approach on osteoarthritic primary chondrocytes HC-OA (Cell Application), exploring on this primary cell line the small sea fish extract's potential to improve the proliferation rate and to stop the cytokines pro-inflammatory signaling. Previous research results have shown an important therapeutic potential of the small sea fish extract, restoring the intrinsic functionality of the cartilage through its correlative effects: antioxidant and anti-inflammatory action, stimulatory activity of cell proliferation and matriceal proteins homeostasis. In the context of pro-inflammatory and degradative stimulation with IL1β, the small sea fish extract prove a counteracting "in vitro" effect, restoring the proliferative capacity of HC-OA cells and inhibiting the IL8 release, with implication in several cartilage degradation pathways: MMP13 activation, neutrophils' accumulation, synovium leucocytes activation, as well as the hypertrophic and differentiation processes of chondrocytes.

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Caffeic acid protects against IL-1β-induced inflammatory responses and cartilage degradation in articular chondrocytes

Cited by 42 publications

References 31 publications

Anti-arthritic activity of D-carvone against complete Freund’s adjuvant-induced arthritis in rats through modulation of inflammatory cytokines

Anti-arthritic activity of D-carvone against complete Freund’s adjuvant-induced arthritis in rats through modulation of inflammatory cytokines

Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

The pharmaceutic capitalization of a natural, marine active principle through in vitro anti-citokinic and proliferative mechanisms of HC-OA osteoarthritic chondrocytes

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