Caffeine and cardiovascular diseases: critical review of current research

Zulli, Anthony; Smith, Renee; Kubatka, Peter; Novák, Jan; Uehara, Yoshio; Loftus, Hayley; Qaradakhi, Tawar; Pohanka, Miroslav; Kobyliak, Nazarii; Zagatina, Angela; Klimas, Ján; Hayes, Alan; Rocca, Giampiero La; Souček, Miroslav; Kružliak, Peter

doi:10.1007/s00394-016-1179-z

Cited by 84 publications

(55 citation statements)

References 137 publications

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“…In animal models of PD, treatment with caffeine ameliorated oxidative stress, restored the depletion of midbrain and striatal dopamine, prevented decline in motor activities and muscular strength, and improved norepinephrine level . All‐cause mortality studies suggest that the inverse association with caffeine may be attributable to caffeine's protection against cardiovascular disease and some cancers . We did not assess specific causes of death among patients because of sample size limitations, but we did control for these comorbidities when assessing all‐cause mortality.…”

Section: Discussionmentioning

confidence: 99%

The association between lifestyle factors and Parkinson's disease progression and mortality

et al. 2019

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Background: Lifestyle factors may contribute to the development of Parkinson’s disease, but little is known about factors that influence progression. The objective of the current study was to examine whether caffeine or alcohol consumption, physical activity, or cigarette smoking is associated with progression and survival among PD patients. Methods: We assessed lifelong coffee, tea, and alcohol consumption, smoking, and physical activity in a prospective community-based cohort (n = 360). All patients were passively followed for mortality (2001–2016); 244 were actively followed on average ± SD 5.3 ± 2.1 years (2007–2014). Movement disorder specialists repeatedly assessed motor function (Hoehn & Yahr) and cognition (Mini-Mental State Exam). We used Cox proportional hazards models and inverse probability weights to account for censoring. Results: Coffee, caffeinated tea, moderate alcohol consumption, and physical activity were protective against at least 1 outcome. Smoking and heavy alcohol consumption were associated with increased risks. Coffee was protective against time to Hoehn & Yahr stage 3 (hazard ratio, 0.52; 95% confidence interval, 0.28–1.01), cognitive decline (hazard ratio, 0.23; 95% confidence interval, 0.11,0.48), and mortality (hazard ratio, 0.47; 95% confidence interval, 0.32–0.69). Relative to moderate drinkers, those who never drank liquor and those who drank more heavily were at an increased risk of Hoehn & Yahr 3 (hazard ratio, 3.48; 95% confidence interval, 1.90–6.38; and hazard ratio, 2.16; 95% confidence interval, 1.03, 4.54, respectively). A history of competitive sports was protective against cognitive decline (hazard ratio, 0.46; 95% confidence interval, 0.22–0.96) and Hoehn & Yahr 3 (hazard ratio, 0.42; 95% confidence interval, 0.23–0.79), as was physical activity measured by metabolic-equivalent hours. Current cigarette smoking was associated with faster cognitive decline (hazard ratio, 3.20; 95% confidence interval, 1.02–10.01). Conclusions: This population-based study suggests that lifestyle factors influence PD progression and mortality.

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Section: Discussionmentioning

confidence: 99%

The association between lifestyle factors and Parkinson's disease progression and mortality

et al. 2019

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“…Some safety concerns are related to its caffeine content, a physiological stimulant with side effects that may affect cardiovascular outcomes [1]. However, a recent meta-analysis showed that moderate coffee consumption was inversely associated with CVD risk, with the lowest CVD risk at three to five cups per day, and that heavy coffee consumption was not associated with elevated CVD risk [2].…”

Section: Introductionmentioning

confidence: 99%

Coffee Drinking and Associated Factors in an Elderly Population in Spain

Torres-Collado

Hera

Navarrete-Muñoz

et al. 2018

IJERPH

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Coffee consumption is highly prevalent worldwide, and many studies have reported positive and inverse associations of coffee with many diseases. However, factors associated with coffee consumption remain poorly characterized in some populations, such as the elderly. This study aimed to assess the factors associated with total, caffeinated and decaffeinated coffee consumption in an elderly population in Spain. Data were analyzed from 903 participants, aged 65 years and above, from two population-based studies carried out in the Valencia region in Spain (Valencia Nutritional Survey (VNS) and European Eye Study (EUREYE-Study). Total, caffeinated and decaffeinated coffee consumption was assessed through two specific questions using a validated food frequency questionnaire. Information on personal characteristics, anthropometry and lifestyles was collected in personal interviews. Multinomial logistic regression analysis was used to estimate the adjusted relative risk ratios (RRR) and confidence intervals (95% CI). The prevalence of total, caffeinated and decaffeinated coffee consumption was 70%, 38% and 32%, respectively. The consumption of caffeinated coffee was positively associated with: Educational level, RRR = 1.63 (1.09–2.44); body mass index (≥30), RRR = 2.03 (1.05–3.95); tobacco smoking, RRR = 1.96 (1.13–3.39); alcohol intake [≥12 g/day category intake vs. no-alcohol intake, RRR = 6.25 (3.56–10.95)]; and energy intake (p < 0.05). Consumption of caffeinated coffee was negatively associated with: Age (≥75 years), RRR = 0.64 (0.43–0.94); and pre-existing hypertension, RRR = 0.67 (0.45–0.98). The consumption of decaffeinated coffee was positively associated with: Alcohol intake, RRR = 2.63 (1.19–4.64); pre-existing diabetes, RRR = 1.67 (1.06–2.62); and energy intake (p < 0.01). The consumption of coffee is high among elderly people in Spain. It is a novelty in this study with elderly population that tobacco smoking and alcohol drinking were the two main factors associated with higher coffee consumption. Self-reported hypertension was associated with a lower consumption of caffeinated coffee, and pre-existing diabetes was associated with a higher consumption of decaffeinated coffee. These associations should be taken into account when the health effects of coffee consumption are investigated.

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“…Nevertheless, the consumption of CAF in higher doses than recommended can lead to the decrements in performance as well as trigger negative effects on the cardiovascular system . Furthermore, chronic use of CAF may led to dependence, tolerance, drug craving, and upon abrupt cessation unpleasant withdrawal symptoms .…”

Section: Introductionmentioning

confidence: 99%

Comparison of GC–MS and MEKC methods for caffeine determination in preworkout supplements

et al. 2019

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In this study, GC–MS‐ and MEKC‐based methods for determination of caffeine (CAF) in preworkout supplements were developed and validated. The proposed protocols utilized minimal sample preparation (simple dilution and syringe filtration). The developed methods achieved satisfactory validation parameters, i.e. good linearity (R2 > 0.9988 and R2 > 0.9985 for GC–MS‐ and MEKC‐based method, respectively), satisfactory intra‐ and interaccuracy (within 92.6–100.7% for method utilizing GC–MS and 92.1–110.3% for protocol based on MEKC) and precision (CV < 15.9% and CV < 6.3% for GC–MS‐ and MEKC‐based method, respectively) and recovery (within 100.1–100.8% for method utilizing GC–MS and 101.5–106.2% for protocol based on MEKC). The LOD was 0.03 and 3 μg/mL for method utilizing GC–MS and MEKC, respectively. The CAF concentrations determined by GC–MS‐ and MEKC‐based methods were found to be in the range of 8.53–11.23 and 8.20–11.61 μg/mL, respectively. Taking into consideration information on the labels, the investigated supplements were found to contain from 110.0 to 167.3% of the declared CAF content, which confirmed the literature reports on incompatibility of the declared product compositions with real ones. Nevertheless, the consumption of examined supplements as recommended by producers did not lead to exceeding the CAF safe limit of 400 mg per day. Additionally, the MEKC‐based method allowed for detection and identification of vitamin B3 and B6 in all of the investigated supplement samples, which demonstrated that MEKC‐based protocols may be an appropriate assays for simultaneous determination of CAF and vitamins.

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Caffeine and cardiovascular diseases: critical review of current research

Cited by 84 publications

References 137 publications

The association between lifestyle factors and Parkinson's disease progression and mortality

The association between lifestyle factors and Parkinson's disease progression and mortality

Coffee Drinking and Associated Factors in an Elderly Population in Spain

Comparison of GC–MS and MEKC methods for caffeine determination in preworkout supplements

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