Caffeine and "Peptic" Ulcer

Roth, James L. A.

doi:10.1001/jama.1944.02850480014004

Cited by 48 publications

(3 citation statements)

References 9 publications

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“…We are therefore reporting our results with a minimum of description but have tabulated them in some detail so that they can be combined with other observations in the future. Roth, Ivy and Atkinson, 1944;Jick et al, 1973;Cole, 1971 …”

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confidence: 99%

A retrospective study of renal cancer with special reference to coffee and animal protein consumption

Armstrong¹,

Garrod²,

Doll³

1976

Br J Cancer

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SHENNAN (1973) drew attention to a strong correlation between coffee consumption and national rates of mortality from renal cancer (simple correlation coefficient r =079). We obtained similar results using incidence as well as mortality rates, and found also a strong geographical correlation between renal cancer incidence and the consumption of animal protein (r 0 82; Armstrong and Doll, 1975). The present study was therefore undertaken to investigate the association between these variables and renal cancer in individuals. We sought also information regarding exposure to other agents which have been reported to be associated with renal cancer in either man or animals, such as tobacco (Bennington and Laubscher, 1968;Schmauz and Cole, 1974;Wynder, Mabuchi and Whitmore, 1974), lead (Van Esch, Van Genderen and Vink, 1962), aromatic amines (Poole-Wilson, 1969), leather (Schmauz and Cole, 1974), compound analgesics (Johansson etal., 1974) and 9 sulphonamides (Hansen and Bichel, 1952).The number of cases studied is small (139) and is effectively made even smaller by the need to consider separately the 2 main types of renal cancer in adults (adenocarcinoma of the parenchyma and transitional cell carcinoma of the pelvis). Statistically significant results could not be expected, therefore, unless we had isolated a factor that greatly increased the risk of the disease. In fact, few of the factors examined appear to have any effect but, with the numbers involved, the possibility of small effects, of the order of two-or three-fold increases in risk, cannot be excluded. Renal cancer is, however, a sufficiently rare disease that it will be difficult for any one group of investigators to accumulate enough experience to provide decisive answers. We are therefore reporting our results with a minimum of description but have tabulated them in some detail so that they can be combined with other observations in the future.

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A retrospective study of renal cancer with special reference to coffee and animal protein consumption

Armstrong¹,

Garrod²,

Doll³

1976

Br J Cancer

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“…Early works showed that caffeine stimulated gastric secretion in man (Roth and Ivy 1944a;Roth et al 1944b). More recently, Debas et al (1971) concluded that both acid and pepsin secretions are stimulated by caffeine administration, but that acid output is more effected.…”

Section: Pharmacological Actionsmentioning

confidence: 99%

The Pharmacology and Toxicology of Caffeine

Lachance

1982

Journal of Food Safety

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The widespread use of caffeine is most commonly linked to the stimulatory action it has on the central nervous system. Generally, adverse effects include gastrorrhea, insomnia, and diuresis. Tolerance and withdrawal symptoms have been observed and excessive consumption can lead to an anxiety neurosis condition (caffeinism). The actions of caffeine may involve its effects on neurotransmitter turnover and metabolism; its promotion of the cellular messenger, cAMP; its sensitization of the calcium releasing mechanisms of cellular reticulum; or its antagonism of the autacoid, adenosine. Caffeine lethality is rare in man but caffeine poisoning with its gastrointestinal, CNS, and cardiovascular stimulation could especially be hazardous to children. Most of the mutagenicity work has been performed in organisms whose cellular DNA synthesis and repair mechanism vary significantly from those found in man. The work in human cell lines suggests that caffeine‐induced chromosomal breakage, with its lack of chromatid exchange would promote cell lethality, not muta‐genticity. Nothing but circumstantial evidence implicates caffeine as a human carcinogen or teratogen. Involvement of caffeine as a cocarcinogen or a coteratogen (which includes effects on gamete production or fetal development) appears far more likely, but neither has even begun to be truly evaluated. Basic metabolism of caffeine involves the processes of N‐demethylation, hydration, and oxidation; and most likely requires the cytochrome P1‐450 system. Though various metabolites of caffeine are pharmacologically active, the extent of involvement of individual metabolites in the pharmacological or toxicological responses of caffeine in man is still unknown.

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“…U gyancsak m agasabb a savürítés nyom bélfekélye-seknél coffein után (56,57,59). Érdekes, hogy ha nor mális gyom rú egyéneknek histam int é s coffeini együtt adnak, akkor épp olyan m agas savtartalm ú és elhúzódó görbe figyelhető meg, mint d uodenális ulcusosoknál csak cöffein után.…”

Section: Coffeinunclassified

Az Orvosi Hetilap 1953 októberi lapszámai

1953

Orvosi Hetilap

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Caffeine and "Peptic" Ulcer

Cited by 48 publications

References 9 publications

A retrospective study of renal cancer with special reference to coffee and animal protein consumption

A retrospective study of renal cancer with special reference to coffee and animal protein consumption

The Pharmacology and Toxicology of Caffeine

Az Orvosi Hetilap 1953 októberi lapszámai

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