Caffeine and Ventricular Arrhythmias

Chelsky, Linda B.; Cutler, Joel E.; Griffith, Karen; Kron, Jack; McClelland, James H.; McAnulty, John H.

doi:10.1001/jama.1990.03450170084027

Cited by 50 publications

(9 citation statements)

References 14 publications

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“…After studies by Sutherland et al (29), Newcombe et al (30), and Chelsky et al (31), results of a review article by Myers (32) also demonstrated that moderate ingestion of caffeine does not increase the frequency of cardiac arrhythmias. In accordance with those studies (about caffeine) and our findings (about energy drinks), Lemery et al (17) also recently indicated that caffeine in moderate doses has no significant impact on cardiac conduction and refractoriness.…”

Section: Discussionmentioning

confidence: 97%

Effects of energy drinks on blood pressure, heart rate, and electrocardiographic parameters: An experimental study on healthy young adults

Hajsadeghi¹,

Mohammadpour²,

Manteghi³

et al. 2015

Anatol J Cardiol

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Objective:To evaluate the effects of the consumption of energy drinks on cardiovascular parameters in a group of healthy young individuals.Methods:In a quasi-experimental study, 44 healthy adult participants aged between 15 and 30 years were evaluated. The blood pressure (BP) as well as electrocardiographic indices, including heart rate (HR), PR interval, QRS duration, corrected QT (QTc) interval, and ST-T changes were recorded before consumption of a caffeine-containing energy drink and at the specific time points over a 4-h test duration.Results:We found statistically significant HR decline (p=0.004) and more frequent ST-T changes (p=0.004) after the participants consumed the energy drink. However, readings for systolic BP (p=0.44), diastolic BP (p=0.26), PR interval (p=0.449), QRS duration (p=0.235), and QTc interval (p=0.953) showed no significant change post-consumption.Conclusion:In conclusion, we demonstrated that the consumption of energy drinks could contribute to HR decline and ST-T change in healthy young adults.

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Section: Discussionmentioning

confidence: 97%

Effects of energy drinks on blood pressure, heart rate, and electrocardiographic parameters: An experimental study on healthy young adults

Hajsadeghi¹,

Mohammadpour²,

Manteghi³

et al. 2015

Anatol J Cardiol

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“…Many of the ingredients that include caffeine alone or in combination with other active substances have the potential to interact with prescription and over-the-counter medications. At typical caffeine doses, however, studies have documented mild changes in heart rate and blood pressure, a slight increase in sympathetic activity, and small changes in cardiac electrophysiological properties (105, 108–110). …”

Section: Central and Peripheral Effects Of Caffeinementioning

confidence: 99%

The Safety of Ingested Caffeine: A Comprehensive Review

Temple¹,

Bernard²,

Lipshultz³

et al. 2017

Front. Psychiatry

383

254

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Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to promote arousal, alertness, energy, and elevated mood. Over the past decade, the introduction of new caffeine-containing food products, as well as changes in consumption patterns of the more traditional sources of caffeine, has increased scrutiny by health authorities and regulatory bodies about the overall consumption of caffeine and its potential cumulative effects on behavior and physiology. Of particular concern is the rate of caffeine intake among populations potentially vulnerable to the negative effects of caffeine consumption: pregnant and lactating women, children and adolescents, young adults, and people with underlying heart or other health conditions, such as mental illness. Here, we review the research into the safety and safe doses of ingested caffeine in healthy and in vulnerable populations. We report that, for healthy adults, caffeine consumption is relatively safe, but that for some vulnerable populations, caffeine consumption could be harmful, including impairments in cardiovascular function, sleep, and substance use. We also identified several gaps in the literature on which we based recommendations for the future of caffeine research.

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“…Figure 3A shows that no incorporation of label into the p21K-S(B) protein was evident. We next investigated whether methylation could be inhibited by methylthioadenosine (MTA), which has been shown to significantly slow the methylesterification of nuclear lamins in vivo (Chelsky et al, 1989). Under these conditions methylation occurred on p2IK-r(B) and K6Q but not on the control K186 protein ( Figure 3).…”

mentioning

confidence: 99%

“…However, since the p21ras methyltransferase has been localized to intracellular membranes (Stephenson and Clarke, 1990;Hrycyna and Clarke, 1990), the experiment was repeated in the presence of canine pancreatic microsomal membranes. Translations of p2lK-ras(B) were therefore performed with added microsomes in the presence of 3 mM MTA, which is close to the limit of solubility of the compound (Chelsky et al, 1989). We next investigated whether methylation could be inhibited by methylthioadenosine (MTA), which has been shown to significantly slow the methylesterification of nuclear lamins in vivo (Chelsky et al, 1989).…”

mentioning

confidence: 99%

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

1991

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Plasma membrane targeting of p21K‐ras(B) requires a CAAX motif and a polybasic domain. The CAAX box directs a triplet of post‐translational modifications: farnesylation, proteolysis of the AAX amino acids and methylesterification. These modifications are closely coupled in vivo. However, in vitro translation of mRNA in rabbit reticulocyte lysates produces p21K‐ras(B) proteins which are arrested in processing after farnesylation. Intracellular membranes are then required both for proteolytic removal of the AAX amino acids and methylesterification of farnesylated p21K‐ras(B). Binding of p21K‐ras(B) to plasma membranes in vitro can then be shown to depend critically on AAX proteolysis and methylesterification since p21K‐ras(B) which is farnesylated, but not methylated, binds inefficiently to membranes.

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Caffeine and Ventricular Arrhythmias

Cited by 50 publications

References 14 publications

Effects of energy drinks on blood pressure, heart rate, and electrocardiographic parameters: An experimental study on healthy young adults

Effects of energy drinks on blood pressure, heart rate, and electrocardiographic parameters: An experimental study on healthy young adults

The Safety of Ingested Caffeine: A Comprehensive Review

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

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