“…There have been some recent reports of polyfunctionalized dihydro-2-oxypyrroles being synthesized via multicomponent processes in the presence of various catalysts including as I 2 , 17 glycine, 18 AcOH, 19 Cu(OAc) 2 .H 2 O, 20 Fe 3 O 4 @nano-cellulose–OPO 3 H, 21 BiFeO 3 nanoparticles, 22 nano-Fe 3 O 4 @SiO 2 /SnCl 4 , 23 glutamic acid, 24 graphene oxide, 25 CoFe 2 O 4 @SiO 2 @IRMOF-3, 26 2,6-pyridinedicarboxylic acid, 27 saccharin, 28 tartaric acid, 29 lemon juice, 30 nano-H 3 PW 12 O 40 /Fe 3 O 4 @SiO 2 -Pr-Pi, 31 UiO-66-SO 3 H, 32 caffeine, 33 nano-TiCl 4 /SiO 2 , 34 Fe/MWCNTs, 35 trityl chloride 36 and EDDF. 37 These methods have resulted in metal catalyst limitations, expensive reagents, harsh reaction conditions, monotonous unacceptable yields, environmental risks, workup processes, and long reaction times.…”