Caffeine as a photoprotective agent for diminishing phototoxicity

Szeto, Yim Tong Savio; Tong, Henry H.Y.

doi:10.1177/0748233710375947

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…Caffeine has been reported to scavenge highly reactive free radicals and to defend crucial biological molecules against these species (Devasagayam et al, 1996). Furthermore, the work of Szeto and Tong (2010) showed that caffeine at 5.0 μmol/L reduced 5-methoxypsoralen-induced phototoxicity with UVC exposure. Caffeine has been used extensively as a cosmetic ingredient not only because of its bioactivity, but also due to its low toxicity profile (Nawrot et al, 2003; Doepker et al, 2016) and numerous works can be found in the literature reporting caffeine skin permeation (Zesch et al, 1979; Dias et al, 1999; Johnson et al, 2006; Herman and Herman, 2013).…”

Section: Introductionmentioning

confidence: 99%

Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant

et al. 2019

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The excessive exposure to ultraviolet (UV) radiation is the main cause of skin cancer, the most commonly diagnosed cancer in the world. In this context, the development of innovative and more effective sunscreens, with bioactive compounds like caffeine, displaying antioxidant and anticancer potential, is required. This research work assessed in vitro and in vivo the efficacy and safety of topical sunscreen formulations containing caffeine as an adjuvant of the UV filters. Sunscreens were prepared with 2.5% w/w caffeine or in the absence of this compound. In order to evaluate the safety of these formulations, stratum corneum hydration, skin barrier and colorimetry were assessed in vivo in healthy subjects before and after skin treatment with the samples. The efficacy of the sunscreens was assessed in vitro , using PMMA plates and a spectrophotometer equipped with an integrating sphere; and in vivo by the determination of the sun protection factor (SPF). None of the formulations caused erythema or impaired the skin barrier function. The in vitro functional characterization showed higher SPF values for the caffeine formulation. The in vivo studies also confirmed the higher SPF value of the formulation combining caffeine with the filters, compared to the caffeine-free sample. This improvement contributed to an increase of, approximately, 25% in the in vivo anti-UVB protection. In conclusion, caffeine was well tolerated by the skin and increased the photoprotective activity, being a new alternative adjuvant in sunscreens formulation.

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Section: Introductionmentioning

confidence: 99%

Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant

et al. 2019

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“…A recent publication showed that combining caffeine with such products reduces phototoxic reactions with UVC exposure—allowing such products to be used more safely. [ 30 ]…”

Section: Introductionmentioning

confidence: 99%

Caffeine in Skincare

Elias,

Israeli,

Madan

2023

Indian Journal of Dermatology

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Caffeine is ubiquitous in our society—not only in the drinks consumed but also increasingly in dermatologic topicals. Given that coffee and caffeine are increasingly used for the production of many dermatologic anti-cancer topicals, sunscreens, and cosmetics, it is of imperative importance to review the basic science and clinical evidence for such claims. In this concise review, we outline the current evidence.

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Bergapten: A review of its pharmacology, pharmacokinetics, and toxicity

Liang

Xie

et al. 2021

Phytotherapy Research

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Bergapten is a natural furocoumarin, also known as 5-methoxypsoralen, and its medicinal value has been paid more and more attention. By sorting out the pharmacological literature of bergapten, we found that bergapten has a wide range of pharmacological effects, including neuroprotection, organ protection, anticancer, antiinflammatory, antimicrobial, and antidiabetes effects. However，bergapten has complex impacts on the hepatic metabolic enzyme. Moreover, pharmacokinetic studies showed that bergapten has higher absolute bioavailability and can cross the blood-brain barrier and has a great potential for treating brain disease, but the mechanism needs further clarification to make greater use of its ability to treat brain diseases. Furthermore, the phototoxicity of bergapten combined with ultraviolet light has always been mentioned. In view of its wide range of pharmacological activities, bergapten is expected to be a potential drug candidate for the treatment of diabetes and diabetes-induced osteoporosis, epilepsy, Alzheimer's disease, depression, and cancer. However, further studies are needed to elucidate its molecular mechanisms and targets. The phototoxicity of bergapten as a side effect should be further avoided. On the other hand, the photoactivation of bergapten in the anticancer aspect can be better utilized.

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Caffeine as a photoprotective agent for diminishing phototoxicity

Cited by 8 publications

References 16 publications

Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant

Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant

Caffeine in Skincare

Bergapten: A review of its pharmacology, pharmacokinetics, and toxicity

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