Caffeine as a Probable Factor for Increased Risk of OAB Development in Elderly People

Abstract

Objective: This study was conducted to compare overactive bladder (OAB) prevalence among people greater than 60 years of age who intake various doses of caffeine, as well as those who abstain from caffeine. Patients and Methods: A randomized observational study was carried out in Vladivostok Gerontological Hospital. A total of 1,098 retired people greater than 60 years of age (659 women and 439 men, average age 67.1 years) took part in the study. They were admitted to the in-patient department with the purpose of annual physical examination performed in accordance with the order of the Ministry of Public Health of the Russian Federation. People over age 60, who at the moment of examination were in satisfactory health condition, were included into the study. People in which OAB had been detected or who used to take antimuscarinic were excluded from the study. Assessment tools for examining the patients' lower urinary tract condition were as follows: OAB-q SF, urination diaries, and uroflowmetry. Results: In the course of the experiment conducted, we found that 1/3 of people, both men and women greater than 60 years of age, who did not previously seek medical advice due to urination troubles, had symptoms of detrusor overactivity. These symptoms were moderate and did not bother patients too much in most cases (63.4%). It was also found that most patients consumed no more than 300mg caffeine with beverages per day, with 30% and 10% of patients suffering from OAB or severe detrusor overactivity, respectively. At the same time, almost 50% of patients taking more than 300 mg of caffeine per day suffer from OAB. Conclusion: 48.1% of people over 60 years of age suffering from overactive detrusor symptoms consume greater than 300 mg caffeine daily, which is significantly higher than that of their peers who do not intake excessive amounts of caffeine.

Treatment compliance of working persons to high-dose antimuscarinic therapies: a randomized trial

“…UUI reduces health-related quality of life, adversely affects the capacity to work, and can be accompanied by emotional stress, reduced social status, and economic problems [Patrick et al 2013; AM treatment remains low [Basra et al 2009;Benner et al 2009]. In earlier studies, we also noted this problem [Kosilov et al 2014[Kosilov et al , 2015. The main reasons of refusals or long breaks in treatment are often specified as the lack of efficacy, occurrence of side effects, high cost of medicines, and lack of income.…”

“…The criteria for inclusion in the group were: Diagnosis: Urinary Incontinence (UI N39.41) [Schafer et al 2002], appointment of AM drugs in standard high doses for long periods of time (per day: solifenacin 10 mg, 20 mg, or trospium 30 mg, 60 mg, oxybutynin 20 mg, tolterodine 4 mg, darifenacin 15 mg) [Felicilda-Reynaldo, 2013]. Due to the data available on the high efficacy and safety of using higher-dose solifenacin and trospium, we also included in the study individuals who were recommended elevated doses of these drugs (20 mg and 60 mg per day respectively) [Horstmann et al 2006;Amend et al 2008;Kosilov et al 2014].…”

Quality of life and the prevalence of urinary incontinence after surgical treatment for gynecologic cancer

“…The diagnosis was cervical cancer in 30.3% (n = 44), endometrial cancer in 40.0% (58), ovarian cancer in 25.5% (37), peritoneal cancer in 2.8% (4), and other disease in 1.4% (2) of respondents. Surgery type was radical hysterectomy in 15.9% (23), modified hysterectomy in 39.3% (57), simple hysterectomy in 15.2% (22), and laparoscopic hysterectomy in 29.7% (43), among which adnexal non-preservation was performed in 81.4% (118), and lymphadenectomy was performed in 60.0% (87) of patients.…”

“…The OAB-q [22] and OABSS [13] are two evaluation tools for OAB for which the reliability and validity have been verified. The OAB-q consists of 8 items regarding symptoms and 25 items for QOL, but it has a major drawback in that the evaluation is time-consuming.…”

Quality of life and the prevalence of urinary incontinence after surgical treatment for gynecologic cancer: A questionnaire survey

“…The OAB-q [29] and OABSS [18] are two evaluation tools for OAB for which the reliability and validity have been veri ed. The OAB-q consists of 8 items regarding symptoms and 25 items for QOL, but it has a major drawback in that the evaluation is time-consuming.…”