Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder

França, Angela Patrícia; Schamne, Marissa Giovanna; Souza, Bruna Soares de; Scheffer, Débora da Luz; Bernardelli, Angelica Karina; Corrêa, Thiago Domingos; Izídio, Geison de Souza; Latini, Alexandra; Silva-Santos, José Eduardo da; Canas, Paula M.; Cunha, Rodrigo A.; Prediger, Rui Daniel

doi:10.1007/s12035-020-02002-4

Cited by 22 publications

(38 citation statements)

References 69 publications

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“…França et al [20] tested the effect of caffeine on the hyperlocomotion characteristic of ADHD, by examining locomotor activity. Caffeine consumption (0.3 mg/mL in drinking water) plus physical exercise in running wheels during 6 weeks, either during adolescence (30 days old) or adulthood (4-5 months old), was not related to changes in spontaneous the open field test.…”

Section: Locomotor Activitymentioning

confidence: 99%

“…The object-recognition task is recognized as a working memory task, relies on the animal's natural tendency for novelty, and tests the ability to discriminate between familiar and unfamiliar objects. França et al [20] assessed working memory using an adapted version of the object recognition task, conducted in an open field during three different phases: habituation, sample and discrimination. Researchers measured the total time spent exploring during the sample phase.…”

Section: Working Memorymentioning

confidence: 99%

“…França et al [20] evaluated the effects of caffeine consumption (0.3 mg/mL) plus physical exercise in running wheels during 6 weeks, either during adolescence (30 days old) or adulthood (4-5 months old), using SHR during the olfactory discrimination test.…”

Section: Olfactory Discriminationmentioning

confidence: 99%

“…França et al [20] measured systolic blood pressure using the non-invasive tail-cuff method. For the animals treated during adolescence, the systolic arterial pressure was taken before (basal values) and 14, 28, and 42 days after beginning the treatment, before the behavioral tests.…”

Section: Blood Pressurementioning

confidence: 99%

“…França et al [20] evaluated the effects of caffeine consumption (0.3 mg/mL in drinking water) plus physical exercise in running wheels during 6 weeks on the brain levels of monoamines, by high-performance liquid chromatography. Regarding SNAP-25 levels in the prefrontal cortex, statistical analysis revealed a significant increase in Synaptosomal-associated protein -25 (SNAP -25) levels in the prefrontal cortex in the group submitted to the association of caffeine consumption plus physical exercise.…”

Section: Brain Levels Of Synaptosomal-associated Protein -25mentioning

confidence: 99%

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Effects of Caffeine Consumption on Attention Deficit Hyperactivity Disorder (ADHD) Treatment: A Systematic Review of Animal Studies

Vázquez¹,

Torre²,

Palomé³

et al. 2021

Preprint

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Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by a persistent pattern of inattention and/or hyperactivity-impulsivity. Neurobiologically, ADHD impairments arise from abnormalities in different circuits involving the prefrontal cortex. In face of high rates of diagnosis, alternative/complementary pharmacological therapeutic approaches for ADHD are needed. Although the number of publications that study the potential effects of caf-feine consumption on ADHD treatment have been accumulating over the last years, and caffeine has recently been used in ADHD research in the context of animal models, an updated evi-dence-based systematic review on the effects of caffeine on ADHD-like symptoms in animal stud-ies is missing. To provide insight and value at the preclinical level, a systematic review based on PRISMA guidelines was performed for all publications available up to September 1, 2021. Caffeine treatment increases attention, improves learning, memory and olfactory discrimination, without altering blood pressure and body weight. These results are supported at the neuronal level. Nonetheless, the implication of caffeine in modulating ADHD-like symptoms of hyperactivity and impulsivity is contradictory, raising discrepancies that require further clarification. Our results strengthen the hypothesis that caffeine cognitive effects found in animal models could be trans-lated to human ADHD, particularly during adolescence.

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Section: Locomotor Activitymentioning

confidence: 99%

Section: Working Memorymentioning

confidence: 99%

Section: Olfactory Discriminationmentioning

confidence: 99%

Section: Blood Pressurementioning

confidence: 99%

Section: Brain Levels Of Synaptosomal-associated Protein -25mentioning

confidence: 99%

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